mart-1-antigen and Osteosarcoma

Osteocartilaginous metaplasia is known to occur rarely in melanomas, particularly in subungual melanomas. We present a case of a calcified subungual soft tissue tumour in which biopsy of the lesion showed malignant round and spindle-shaped tumour cells, many of which were associated with the formation of cartilage and osteoid-like material. Subsequent resection showed clear histological evidence of a subungual melanoma. Tumour cells expressed S100, melan-A and neurone-specific enolase but were negative for HMB45. Diagnostic radiological and histological features and the nature of the osteocartilaginous differentiation within this lesion is discussed.

Topics: Antigens, Neoplasm; Biomarkers, Tumor; Biopsy; Bone Neoplasms; Cartilage; Diagnosis, Differential; Fingers; Humans; Magnetic Resonance Imaging; Male; MART-1 Antigen; Melanoma; Melanoma-Specific Antigens; Middle Aged; Neoplasm Proteins; Osteochondroma; Osteosarcoma; Phosphopyruvate Hydratase; Soft Tissue Neoplasms; Tomography, X-Ray Computed