mart-1-antigen and Intestinal-Neoplasms

Clear-cell sarcoma is a rare, malignant soft tissue tumor that displays melanocytic differentiation with a distinct molecular profile. It is rarely localized in the gastrointestinal tract. Herein we reported a case of multiple synchronous clear-cell sarcomas of the gastrointestinal tract with parotid gland metastasis. A 51-year-old male patient presented with a growing painless mass under the right ear. A preoperative positron emission tomography/computed tomography showed multiple intestinal masses and a mass in the right parotid with increased glucose uptake, and he underwent operative treatment with resection of three tumors in the jejunum and ileum and then received a right parotidectomy. Postoperative pathological examination showed that cells in the intestinal tumor were consistent with clear-cell sarcoma of the gastrointestinal tract, and the malignant cells in the parotid gland were similar to the intestinal tumor. Immunohistochemical studies revealed positive expression of HMB-45, Melan-A, and S-100. EWSR1 gene fusion transcripts were undetectable by fluorescence

Topics: Biomarkers, Tumor; gp100 Melanoma Antigen; Humans; Immunohistochemistry; Intestinal Neoplasms; Intestine, Small; Male; MART-1 Antigen; Melanoma-Specific Antigens; Middle Aged; Neoplasm Metastasis; Parotid Gland; Positron Emission Tomography Computed Tomography; S100 Proteins; Salivary Gland Neoplasms; Sarcoma, Clear Cell