mart-1-antigen and Influenza--Human

mart-1-antigen has been researched along with Influenza--Human* in 2 studies

Other Studies

2 other study(ies) available for mart-1-antigen and Influenza--Human

Article	Year
Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8 Journal of immunology (Baltimore, Md. : 1950), 2022, 02-01, Volume: 208, Issue:3 Aging is associated with functional deficits in the naive T cell compartment, which compromise the generation of de novo immune responses against previously unencountered Ags. The mechanisms that underlie this phenomenon have nonetheless remained unclear. We found that naive CD8 Topics: Adult; Aged; Aged, 80 and over; Aging; Apoptosis; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cell Division; COVID-19; Female; Fenofibrate; Glucose; HLA-A2 Antigen; Humans; Hypolipidemic Agents; Immunocompetence; Influenza, Human; Lipid Metabolism; Lymphocyte Activation; Male; MART-1 Antigen; Middle Aged; Neoplasms; Peptide Fragments; Rosiglitazone; Single-Blind Method; Vaccination; Viral Vaccines; Young Adult	2022
RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy. Blood, 2004, Mar-15, Volume: 103, Issue:6 Vaccination with antigen-presenting cells (APCs) engineered to mimic mechanisms of immune stimulation represents a promising approach for cancer immunotherapy. Dendritic cell vaccines have entered phase 3 testing in adult malignancies, but such vaccines in children have been limited. We demonstrate that CD40-activated B cells (CD40-B) transfected with RNA may serve as an alternative vaccine that can be generated from small blood volumes regardless of patient age. CD40-B from pediatric patients are efficient APCs and can be loaded with RNA as an antigenic payload, permitting simultaneous targeting of multiple antigenic epitopes without the necessity of HLA matching. For viral and tumor antigens, CD40-B/RNA technology induced cytotoxic T lymphocytes (CTLs) from adults and children, which could be identified with peptide/major histocompatibility complex (MHC) tetramers. These CTLs secreted interferon-gamma (IFN-gamma) and killed targets in an MHC-restricted fashion. For pooled neuroblastoma RNA and autologous neuroblastoma RNA, CTLs that lysed neuroblastoma cell lines, including CTLs specific against the widely expressed tumor-antigen survivin, were generated. These findings support a novel platform for tumor-specific vaccine or adoptive immunotherapies in pediatric malignancies. Topics: Adult; Age Factors; Animals; Antigens, Neoplasm; Antigens, Viral; B-Lymphocytes; Cancer Vaccines; CD40 Antigens; Child; Electroporation; Humans; Immunotherapy; In Vitro Techniques; Influenza, Human; Lymphocyte Activation; MART-1 Antigen; Mice; Neoplasm Proteins; NIH 3T3 Cells; RNA, Messenger; T-Lymphocytes; Transfection	2004

Article

Year

Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8

Journal of immunology (Baltimore, Md. : 1950), 2022, 02-01, Volume: 208, Issue:3

Aging is associated with functional deficits in the naive T cell compartment, which compromise the generation of de novo immune responses against previously unencountered Ags. The mechanisms that underlie this phenomenon have nonetheless remained unclear. We found that naive CD8

Topics: Adult; Aged; Aged, 80 and over; Aging; Apoptosis; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cell Division; COVID-19; Female; Fenofibrate; Glucose; HLA-A2 Antigen; Humans; Hypolipidemic Agents; Immunocompetence; Influenza, Human; Lipid Metabolism; Lymphocyte Activation; Male; MART-1 Antigen; Middle Aged; Neoplasms; Peptide Fragments; Rosiglitazone; Single-Blind Method; Vaccination; Viral Vaccines; Young Adult

2022

RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy.

Blood, 2004, Mar-15, Volume: 103, Issue:6

Vaccination with antigen-presenting cells (APCs) engineered to mimic mechanisms of immune stimulation represents a promising approach for cancer immunotherapy. Dendritic cell vaccines have entered phase 3 testing in adult malignancies, but such vaccines in children have been limited. We demonstrate that CD40-activated B cells (CD40-B) transfected with RNA may serve as an alternative vaccine that can be generated from small blood volumes regardless of patient age. CD40-B from pediatric patients are efficient APCs and can be loaded with RNA as an antigenic payload, permitting simultaneous targeting of multiple antigenic epitopes without the necessity of HLA matching. For viral and tumor antigens, CD40-B/RNA technology induced cytotoxic T lymphocytes (CTLs) from adults and children, which could be identified with peptide/major histocompatibility complex (MHC) tetramers. These CTLs secreted interferon-gamma (IFN-gamma) and killed targets in an MHC-restricted fashion. For pooled neuroblastoma RNA and autologous neuroblastoma RNA, CTLs that lysed neuroblastoma cell lines, including CTLs specific against the widely expressed tumor-antigen survivin, were generated. These findings support a novel platform for tumor-specific vaccine or adoptive immunotherapies in pediatric malignancies.

Topics: Adult; Age Factors; Animals; Antigens, Neoplasm; Antigens, Viral; B-Lymphocytes; Cancer Vaccines; CD40 Antigens; Child; Electroporation; Humans; Immunotherapy; In Vitro Techniques; Influenza, Human; Lymphocyte Activation; MART-1 Antigen; Mice; Neoplasm Proteins; NIH 3T3 Cells; RNA, Messenger; T-Lymphocytes; Transfection

2004