mart-1-antigen and Facial-Neoplasms

Metastases to the oral cavity are unusual, and most cases affect the jaws. The clinicopathologic features of a metastatic melanoma involving the mandibular gingiva and facial skin are described.. A 42-year-old white woman who had been treated for plantar melanoma 10 years ago showed concomitant nodular lesions in the mandibular gingiva and facial skin. Incisional biopsy and fine needle aspiration cytology were performed in the gingival and facial swelling, respectively.. Radiographs revealed irregular bone erosion and widening of the periodontal ligament space associated with the gingival lesion, whereas cranial computed tomography showed an irregular hyperdense mass associated with the dermal tissue. The histopathologic findings were suggestive of melanoma; immunohistochemical analysis revealed, in both lesions, neoplastic cells strongly positive for S100 and HMB-45 antibodies and weak reactivity for melan-A. The final diagnosis of these lesions was metastatic melanoma, and the patient died before restarting treatment.. To the best of our knowledge, this is the first English-language report of metastatic melanoma affecting the gingiva and facial skin concomitantly. The intraoral involvement of disseminated melanoma indicates a very poor prognosis, as confirmed by the current case.

Topics: Adult; Antigens, Neoplasm; Biopsy; Biopsy, Fine-Needle; Facial Neoplasms; Fatal Outcome; Female; Foot Diseases; Gingival Neoplasms; Humans; MART-1 Antigen; Melanoma; Melanoma-Specific Antigens; Neoplasm Proteins; S100 Proteins; Tomography, X-Ray Computed

We report an 89-year-old man who presented with a slowly growing pigmented pedunculated tumor. The nodule was diagnosed as a spindle cell pedunculated malignant melanoma (PMM), a rare variant of spindle-cell malignant melanoma. The clinical presentation of this tumor and its histological and immunohistological features are discussed.

Topics: Aged, 80 and over; Biomarkers, Tumor; Facial Neoplasms; gp100 Melanoma Antigen; Humans; Immunohistochemistry; Male; MART-1 Antigen; Melanoma; Melanoma-Specific Antigens

A combined squamomelanocytic tumor is an exceedingly rare occurrence; little is known about its pathogenesis. A definitive diagnosis can only be made via histological examination. We describe herein an 83 year-old man who was discovered to have this combined tumor and recommend the appropriate management for such a lesion.

Topics: Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; Facial Neoplasms; gp100 Melanoma Antigen; Humans; Keratins; Male; MART-1 Antigen; Melanins; Melanoma; Melanoma-Specific Antigens; Neoplasms, Multiple Primary; S100 Proteins; Skin Neoplasms

We present the unusual case of a perivascular epithelioid cell tumor (PEComa) occurring within the cheek of a 32-year-old woman. PEComa is a rare, recently described, family of tumors with diverse clinicopathologic expression and which express melanocytic and muscle markers. It mainly affects the abdominopelvic region and rarely occurs in somatic soft tissue or skin. To our knowledge, this is the first reported case of PEComa occurring in the facial cutaneous tissues. Other possible diagnoses considered included benign mesenchymal tumors of smooth muscle or neural origin. However, the cytomorphologic and immunohistochemical profile were most suggestive of PEComa. The tumor was completely excised, but in view of uncertainty as to how this entity would behave in an unusual location, lifelong follow up is recommended. After complete excision, there was no recurrence in 4 years.

Topics: Actins; Adult; Antigens, Neoplasm; Arterioles; Cheek; Diagnosis, Differential; Epithelioid Cells; Facial Neoplasms; Female; Follow-Up Studies; Humans; MART-1 Antigen; Muscle, Smooth, Vascular; Neoplasm Proteins; Perivascular Epithelioid Cell Neoplasms; Soft Tissue Neoplasms

The diagnosis of malignant melanoma can be challenging given the wide variation in morphologic features and immunohistochemical stains are often used to confirm the diagnosis. We report a case of melanoma with loss of staining for S100 protein, HMB-45, and Melan-A, with retained expression of tyrosinase. Regional lymph node metastases showed positive S100 protein staining. Although the loss of phenotypic markers including S100 protein has been reported in metastatic melanoma, loss of S100 in primary melanoma is rare. Discordant staining between primary and metastatic lesions further emphasizes the protean nature of melanoma.

Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antigens, Neoplasm; Antineoplastic Agents; Biomarkers, Tumor; Combined Modality Therapy; Facial Neoplasms; Fatal Outcome; Humans; Lymphatic Metastasis; Male; MART-1 Antigen; Melanoma; Melanoma-Specific Antigens; Middle Aged; Monophenol Monooxygenase; Neoplasm Proteins; Palliative Care; S100 Proteins; Shoulder; Skin Neoplasms

Topics: Adult; Antigens, Neoplasm; Biomarkers, Tumor; Facial Neoplasms; Humans; Immunoenzyme Techniques; Male; MART-1 Antigen; Melanocytes; Melanoma; Melanoma-Specific Antigens; Neoplasm Proteins; Sensitivity and Specificity; Skin; Skin Neoplasms

Topics: Aged; Antigens, Neoplasm; Facial Neoplasms; Humans; Male; MART-1 Antigen; Melanoma-Specific Antigens; Melanoma, Amelanotic; Melanosomes; Neoplasm Proteins