mart-1-antigen has been researched along with Carcinoma--Merkel-Cell* in 1 studies
1 other study(ies) available for mart-1-antigen and Carcinoma--Merkel-Cell
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CK20/CK7 double-negative Merkel cell carcinoma in situ: A case report.
An 83-year-old male with a history of both melanoma and non-melanoma skin cancers presented with a light pink non-ulcerated slightly raised 0.6 × 0.5-cm papule on his left lower extremity. Biopsy specimen revealed a proliferation of intraepidermal round blue cells. On immunohistochemical staining, CD56, chromogranin, and pancytokeratin were faintly positive within the lesional population, while synaptophysin was strongly positive. CD45, CK5/6, CK7, CK20, Melan-A, SOX10, and TTF-1 stains were negative. There was no dermal component identified. A Merkel cell polyomavirus stain was negative. Distant metastases and other in situ pathologies were excluded and a diagnosis of Merkel cell carcinoma in situ (MMCIS) was made. The majority of MCCIS lesions reported in the literature have been discovered amongst other non-melanoma neoplasms. Our findings of an MCCIS with purely intraepidermal involvements without the association with another squamous cell neoplasm is rare finding. Topics: Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Merkel Cell; Chromogranins; Humans; Male; MART-1 Antigen; Skin Neoplasms; Synaptophysin | 2022 |