marinobufagenin has been researched along with Hemolysis* in 1 studies
1 other study(ies) available for marinobufagenin and Hemolysis
| Article | Year |
|---|---|
Marinobufagin, a molecule from poisonous frogs, causes biochemical, morphological and cell cycle changes in human neoplasms and vegetal cells.
Skin toad secretion present physiologically active molecules to protect them against microorganisms, predators and infections. This work detailed the antiproliferative action of marinobufagin on tumor and normal lines, investigate its mechanism on HL-60 leukemia cells and its toxic effects on Allium cepa meristematic cells. Initially, cytotoxic action was assessed by colorimetric assays. Next, HL-60 cells were analyzed by morphological and flow cytometry techniques and growing A. cepa roots were examined after 72 h exposure. Marinobufagin presented high antiproliferative action against all human tumor lines [IC Topics: Adolescent; Adult; Animals; Antineoplastic Agents; Bufanolides; Bufonidae; Cell Cycle; Cell Survival; Comet Assay; DNA Breaks; Dose-Response Relationship, Drug; Erythrocytes; Healthy Volunteers; Hemolysis; HL-60 Cells; Humans; Leukocytes, Mononuclear; Meristem; Micronuclei, Chromosome-Defective; Onions; Skin; Young Adult | 2018 |