maprotiline has been researched along with Seizures in 33 studies
Maprotiline: A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eleven McLean Hospital (Belmont, Mass) depressed patients who experienced seizures while receiving maprotiline hydrochloride are presented, as are data on 87 cases reported to the manufacturer (Ciba-Geigy)." | 7.67 | Maprotiline treatment in depression. A perspective on seizures. ( Cole, JO; Dessain, EC; Schatzberg, AF; Woods, BT, 1986) |
| "The involvement of chronic inhibition of monoamine transporters (MAT) in the brain with respect to sensitization to cocaine- and local anesthetic-induced seizures was studied in mice." | 3.72 | Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics. ( Arai, S; Dohi, T; Kihira, K; Kitayama, S; Kumagai, K; Kumagai, M; Morita, K, 2003) |
| "Eleven McLean Hospital (Belmont, Mass) depressed patients who experienced seizures while receiving maprotiline hydrochloride are presented, as are data on 87 cases reported to the manufacturer (Ciba-Geigy)." | 3.67 | Maprotiline treatment in depression. A perspective on seizures. ( Cole, JO; Dessain, EC; Schatzberg, AF; Woods, BT, 1986) |
| "Nomifensine was withdrawn from markets worldwide because of reports of serious hypersensitivity reactions, especially hemolytic anemia, and marketing of bupropion in the United States was delayed after seizures occurred in bulimic patients in clinical trials." | 2.37 | Adverse reactions to five new antidepressants. ( Hayes, PE; Kristoff, CA, 1986) |
| "The electrocardiogram showed a right bundle branch block and a left anterior hemiblock over 72 h." | 1.28 | [Maprotiline poisoning in an eleven-month-old infant]. ( Bétremieux, P; Breurec, JY; Dabadie, A; Durand, C; Lefrançois, C; Roussey, M, 1990) |
| "Minimal electroshock seizure threshold (EST) was not significantly altered by L-DOPS at a dose of 200 or 400 mg/kg." | 1.28 | [Inhibitory effects of L-threo-DOPS on electroshock seizure in mice]. ( Nakanishi, T; Yoshida, M, 1989) |
| "Fifteen patients were in coma grade III or IV; 17 patients were still not conscious after 24 hours in the intensive care unit." | 1.27 | Effects of self poisoning with maprotiline. ( Heath, A; Knudsen, K, 1984) |
| "On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg)." | 1.27 | Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. ( Bradford, D; Krijzer, F; Snelder, M, 1984) |
| "A 6-year-old girl presented with tonic-clonic seizures and generalized convulsions lasting several minutes." | 1.27 | Maprotiline poisoning in a child. ( Ashwal, S; Petry, E; Peverini, R, 1988) |
| "Seizures were more common in the amoxapine (24." | 1.27 | Relative toxicity of cyclic antidepressants. ( Gorman, RL; Klein-Schwartz, W; Oderda, GM; Wedin, GP, 1986) |
| "In four patients the seizure followed the institution of maprotiline therapy by less than three weeks." | 1.27 | Incidence of seizures with tricyclic and tetracyclic antidepressants. ( Bryan, GE; Gunderson, CH; Jabbari, B; Marsh, EE, 1985) |
| "Generalised seizures were seen 15-30 min after imipramine or chlorimipramine (20 mg/kg), and these two drugs showed no difference in their epileptogenicity." | 1.26 | Seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms. ( Anlezark, G; Meldrum, B; Trimble, M, 1977) |
| " It is concluded that all four drugs show the toxic effects classically associated with tricyclic antidepressants but the relative toxicity amongst these agents varies considerably and is in the order amitriptyline greater than imipramine greater than maprotiline greater than mianserin." | 1.26 | The relative toxicity of amitriptyline, imipramine, maprotiline and mianserin in rabbits in vivo. ( Hughes, IE; Radwan, S, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (87.88) | 18.7374 |
| 1990's | 2 (6.06) | 18.2507 |
| 2000's | 1 (3.03) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmad, SA | 1 |
| Mujawar, Q | 1 |
| Bawardi, NA | 1 |
| Arai, S | 1 |
| Morita, K | 1 |
| Kitayama, S | 1 |
| Kumagai, K | 1 |
| Kumagai, M | 1 |
| Kihira, K | 1 |
| Dohi, T | 1 |
| Flechter, S | 1 |
| Rabey, JM | 1 |
| Regev, I | 1 |
| Borenstein, N | 1 |
| Vardi, J | 1 |
| Rudorfer, MV | 1 |
| Golden, RN | 2 |
| Potter, WZ | 1 |
| Knudsen, K | 1 |
| Heath, A | 1 |
| Krijzer, F | 1 |
| Snelder, M | 1 |
| Bradford, D | 1 |
| Smith, M | 1 |
| Angrist, B | 1 |
| Cooper, T | 1 |
| Ramirez, AL | 1 |
| Price, SL | 1 |
| Mukherjee, S | 1 |
| Bick, P | 1 |
| Trimble, M | 1 |
| Anlezark, G | 2 |
| Meldrum, B | 1 |
| Piccini, P | 1 |
| Pierri, A | 1 |
| Costa, PP | 1 |
| Panza, N | 1 |
| Koella, WP | 1 |
| Glatt, A | 1 |
| Klebs, K | 1 |
| Dürst, T | 1 |
| Hughes, IE | 1 |
| Radwan, S | 1 |
| Trimble, MR | 1 |
| Meldrum, BS | 1 |
| Meek, D | 1 |
| Bott, MH | 1 |
| Mamtora, H | 1 |
| Gabriel, R | 1 |
| Szeless, S | 1 |
| Kleinberger, G | 1 |
| Kotzaurek, R | 1 |
| Pall, H | 1 |
| Pichler, M | 1 |
| Raberger, G | 1 |
| Maj, J | 1 |
| Rogóz, Z | 1 |
| Skuza, G | 1 |
| Sowińska, H | 1 |
| Bétremieux, P | 1 |
| Durand, C | 1 |
| Lefrançois, C | 1 |
| Roussey, M | 1 |
| Breurec, JY | 1 |
| Dabadie, A | 1 |
| Yoshida, M | 1 |
| Nakanishi, T | 1 |
| Brown, TM | 1 |
| Miller, H | 1 |
| Evans, DL | 2 |
| Hayes, PE | 1 |
| Kristoff, CA | 1 |
| Peverini, R | 1 |
| Ashwal, S | 1 |
| Petry, E | 1 |
| Strawn, SK | 1 |
| Pederson, CA | 1 |
| Rasmussen, BK | 1 |
| Gelzer, J | 1 |
| Wedin, GP | 1 |
| Oderda, GM | 1 |
| Klein-Schwartz, W | 1 |
| Gorman, RL | 1 |
| Bernard, PG | 1 |
| Levine, MS | 1 |
| Dessain, EC | 1 |
| Schatzberg, AF | 1 |
| Woods, BT | 1 |
| Cole, JO | 1 |
| Jabbari, B | 1 |
| Bryan, GE | 1 |
| Marsh, EE | 1 |
| Gunderson, CH | 1 |
| Kranzler, H | 1 |
4 reviews available for maprotiline and Seizures
| Article | Year |
|---|---|
Second-generation antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Benzodiazepines; Bupropion; Citalopram; Clinical Trial | 1984 |
The new antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Fluoxetine; Maprotiline; Nomifensine; Seizures; Trazod | 1988 |
Adverse reactions to five new antidepressants.
Topics: Acute Kidney Injury; Amoxapine; Animals; Antidepressive Agents; Bupropion; Cardiovascular Diseases; | 1986 |
Limits to chemotherapy of depression.
Topics: Antidepressive Agents; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Maprotiline; S | 1986 |
2 trials available for maprotiline and Seizures
| Article | Year |
|---|---|
Second-generation antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Benzodiazepines; Bupropion; Citalopram; Clinical Trial | 1984 |
Worldwide clinical experience with ludiomil.
Topics: Anthracenes; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Double | 1982 |
28 other studies available for maprotiline and Seizures
| Article | Year |
|---|---|
A 14-month-old child with staring gaze and a blocked heart.
Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents, Second-Generation; Consciousness Disorders; Dia | 2014 |
Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics.
Topics: Adrenergic Uptake Inhibitors; Anesthetics, Local; Animals; Brain; Brain Chemistry; Citalopram; Cocai | 2003 |
Convulsive attacks due to antidepressant drug overdoses: case reports and discussion.
Topics: Adult; Antidepressive Agents; Cerebral Cortex; Clomipramine; Dibenzazepines; Electroencephalography; | 1983 |
Effects of self poisoning with maprotiline.
Topics: Adult; Aged; Anthracenes; Arrhythmias, Cardiac; Coma; Electrocardiography; Female; Humans; Male; Map | 1984 |
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Re | 1984 |
Seizures associated with a high plasma maprotiline level.
Topics: Anthracenes; Humans; Male; Maprotiline; Middle Aged; Seizures | 1983 |
Seizures associated with maprotiline.
Topics: Adult; Anthracenes; Depressive Disorder; Female; Humans; Male; Maprotiline; Seizures | 1983 |
Seizures: a frequent side effect of ludiomil.
Topics: Anthracenes; Depression; Epilepsy; Humans; Male; Maprotiline; Middle Aged; Seizures | 1982 |
More on maprotiline-induced seizures.
Topics: Adult; Anthracenes; Female; Humans; Maprotiline; Seizures | 1982 |
Seizures and maprotiline.
Topics: Anthracenes; Depressive Disorder; Humans; Male; Maprotiline; Middle Aged; Seizures | 1982 |
Seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Electroencephal | 1977 |
[Acute poisoning by tricyclic antidepressive agents].
Topics: Acute Disease; Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antidepressive Agents, Tricyclic; A | 1979 |
Epileptic phenomena induced in the cat by the antidepressants maprotiline, imipramine, clomipramine, and amitriptyline.
Topics: Amitriptyline; Animals; Anthracenes; Cats; Cerebral Cortex; Clomipramine; Electroencephalography; Ev | 1979 |
The relative toxicity of amitriptyline, imipramine, maprotiline and mianserin in rabbits in vivo.
Topics: Amitriptyline; Anesthesia; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Behavior | 1979 |
Effect of nomifensine on brain amines and epilepsy in photosensitive baboons.
Topics: Amines; Animals; Brain Chemistry; Clomipramine; Dose-Response Relationship, Drug; Imipramine; Isoqui | 1977 |
Letter: Convulsin following maprotiline overdose.
Topics: Adult; Anthracenes; Antidepressive Agents, Tricyclic; Female; Humans; Maprotiline; Seizures; Suicide | 1975 |
[Fatal self-poisoning with the tetracyclic antidepressive drug, ludiomil (author's transl)].
Topics: Adult; Anthracenes; Bundle-Branch Block; Chemical Phenomena; Chemistry; Coma; Depression; Female; Hu | 1975 |
The effect of antidepressant drugs on the locomotor hyperactivity induced by MK-801, a non-competitive NMDA receptor antagonist.
Topics: Animals; Antidepressive Agents; Benzazepines; Citalopram; Dizocilpine Maleate; Fluoxetine; Imipramin | 1992 |
[Maprotiline poisoning in an eleven-month-old infant].
Topics: Anthracenes; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Bundle-Branch Block; Clobazam; | 1990 |
[Inhibitory effects of L-threo-DOPS on electroshock seizure in mice].
Topics: Animals; Anticonvulsants; Desipramine; Droxidopa; Drug Therapy, Combination; Electroshock; Male; Map | 1989 |
Maprotiline poisoning in a child.
Topics: Anthracenes; Brain; Child; Combined Modality Therapy; Electrocardiography; Female; Humans; Maprotili | 1988 |
Alcohol precipitation of maprotiline-associated seizures.
Topics: Adult; Anthracenes; Drug Synergism; Ethanol; Female; Humans; Maprotiline; Seizures | 1988 |
[Seizure occurring during treatment with antidepressive agents].
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Female; Humans; Male; Maprotiline; Middle Age | 1987 |
Relative toxicity of cyclic antidepressants.
Topics: Adolescent; Adult; Aged; Amoxapine; Anthracenes; Antidepressive Agents, Tricyclic; Arrhythmias, Card | 1986 |
Maprotiline-induced seizures.
Topics: Adult; Anthracenes; Depressive Disorder; Female; Humans; Maprotiline; Seizures | 1986 |
Maprotiline treatment in depression. A perspective on seizures.
Topics: Adult; Aged; Anthracenes; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Mal | 1986 |
Incidence of seizures with tricyclic and tetracyclic antidepressants.
Topics: Adult; Aged; Anthracenes; Antidepressive Agents; Antidepressive Agents, Tricyclic; Female; Humans; M | 1985 |
Tonic-clonic seizures with maprotiline.
Topics: Adult; Anthracenes; Depressive Disorder; Female; Humans; Maprotiline; Seizures | 1985 |