maprotiline has been researched along with Epilepsy in 8 studies
Maprotiline: A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg)." | 1.27 | Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. ( Bradford, D; Krijzer, F; Snelder, M, 1984) |
| "Amitriptyline was the most effective antidepressant, attenuating both seizure severity and afterdischarge duration." | 1.27 | Acute effects of antidepressants on hippocampal seizures. ( Clifford, DB; Hicks, FG; Rutherford, JL; Zorumski, CF, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Flechter, S | 1 |
| Rabey, JM | 1 |
| Regev, I | 1 |
| Borenstein, N | 1 |
| Vardi, J | 1 |
| Krijzer, F | 1 |
| Snelder, M | 1 |
| Bradford, D | 1 |
| Atri, PB | 1 |
| Julius, DA | 1 |
| Sedgwick, EM | 1 |
| Edwards, JG | 1 |
| Pisani, F | 1 |
| Spina, E | 1 |
| Oteri, G | 1 |
| Marks, P | 1 |
| Anderson, J | 1 |
| Vincent, R | 1 |
| Hutchinson, JT | 1 |
| Rees, HM | 1 |
| Clifford, DB | 1 |
| Rutherford, JL | 1 |
| Hicks, FG | 1 |
| Zorumski, CF | 1 |
1 review available for maprotiline and Epilepsy
| Article | Year |
|---|---|
Antidepressant drugs and seizure susceptibility: from in vitro data to clinical practice.
Topics: Amoxapine; Animals; Antidepressive Agents; Comorbidity; Contraindications; Depressive Disorder; Dose | 1999 |
1 trial available for maprotiline and Epilepsy
| Article | Year |
|---|---|
Mianserin, maprotiline and the electroencephalogram.
Topics: Adult; Anthracenes; Dibenzazepines; Electroencephalography; Epilepsy; Female; Humans; Male; Maprotil | 1983 |
6 other studies available for maprotiline and Epilepsy
| Article | Year |
|---|---|
Convulsive attacks due to antidepressant drug overdoses: case reports and discussion.
Topics: Adult; Antidepressive Agents; Cerebral Cortex; Clomipramine; Dibenzazepines; Electroencephalography; | 1983 |
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Re | 1984 |
Maprotiline hydrochloride associated with a clinical state of catatonic stupor and epileptic encephalogram.
Topics: Anthracenes; Catatonia; Depressive Disorder; Diazepam; Drug Therapy, Combination; Electroencephalogr | 1984 |
Seizures: a frequent side effect of ludiomil.
Topics: Anthracenes; Depression; Epilepsy; Humans; Male; Maprotiline; Middle Aged; Seizures | 1982 |
Epileptiform seizures with maprotiline hydrochloride.
Topics: Adult; Anthracenes; Diazepam; Epilepsy; Female; Humans; Male; Maprotiline; Middle Aged | 1979 |
Acute effects of antidepressants on hippocampal seizures.
Topics: Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Bupropion; Desipramine; Epilepsy; Hi | 1985 |