maprotiline has been researched along with Epilepsy, Tonic-Clonic in 11 studies
Maprotiline: A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Maprotiline is a tetracyclic antidepressant which appears to have accounted for a relatively large proportion of the seizures associated with antidepressant use." | 1.27 | Seizures associated with high maprotiline serum concentrations. ( Molnar, G, 1983) |
| "Maprotiline has been reported to be less likely to cause epileptic seizures than the tricyclic antidepressants." | 1.26 | Maprotiline and seizures. ( Hoffman, BF; Wachsmuth, R, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (90.91) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Molnar, G | 1 |
| Northup, L | 1 |
| Reed, G | 1 |
| McAnalley, B | 1 |
| Anderson, RJ | 1 |
| Schwartz, L | 1 |
| Swaminathan, S | 1 |
| Hoffman, BF | 1 |
| Wachsmuth, R | 1 |
| Holliday, W | 1 |
| Brasfield, KH | 1 |
| Powers, B | 1 |
| Kim, WY | 1 |
| Orser, B | 1 |
| Oxorn, D | 1 |
| Hall, MJ | 1 |
| Russell, RI | 1 |
| Burley, D | 1 |
| Jukes, A | 1 |
| Steen, J | 1 |
| Trimble, M | 1 |
| Shepherd, GA | 1 |
| Kerr, F | 1 |
11 other studies available for maprotiline and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Seizures associated with high maprotiline serum concentrations.
Topics: Adult; Anthracenes; Depressive Disorder; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; F | 1983 |
Seizures due to maprotiline overdose.
Topics: Adult; Anthracenes; Emergencies; Epilepsy, Tonic-Clonic; Female; Gastric Lavage; Humans; Maprotiline | 1984 |
Maprotiline hydrochloride and convulsions: a case report.
Topics: Aminophylline; Anthracenes; Depressive Disorder; Drug Interactions; Epilepsy, Tonic-Clonic; Heart Fa | 1982 |
Maprotiline and seizures.
Topics: Adult; Anthracenes; Chlorpromazine; Depressive Disorder; Drug Therapy, Combination; Epilepsy, Tonic- | 1982 |
Grand mal seizures induced by maprotiline.
Topics: Adult; Anthracenes; Depressive Disorder; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; H | 1982 |
Seizures associated with maprotiline.
Topics: Anthracenes; Depressive Disorder; Epilepsy, Tonic-Clonic; Female; Humans; Maprotiline; Middle Aged | 1982 |
Propofol, seizure and antidepressants.
Topics: Adult; Anesthesia, Intravenous; Drug Interactions; Electroencephalography; Epilepsy, Tonic-Clonic; H | 1994 |
Maprotiline hydrochloride and grand-mal seizures.
Topics: Adult; Anthracenes; Epilepsy, Tonic-Clonic; Female; Humans; Maprotiline | 1978 |
Maprotiline hydrochloride and grand-mal seizures.
Topics: Anthracenes; Drug Administration Schedule; Epilepsy, Tonic-Clonic; Female; Humans; Maprotiline | 1978 |
Maprotiline hydrochloride and grand-mal seizures.
Topics: Anthracenes; Antidepressive Agents; Epilepsy, Tonic-Clonic; Humans; Maprotiline | 1978 |
Maprotiline hydrochloride and grand-mal seizures.
Topics: Adult; Anthracenes; Epilepsy, Tonic-Clonic; Female; Humans; Maprotiline | 1978 |