maprotiline has been researched along with Burkitt Lymphoma in 3 studies
Maprotiline: A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
Burkitt Lymphoma: A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report that the SSRI fluoxetine and the NSRI maprotiline are potent antiproliferative agents against human Burkitt lymphoma (BL), having little effect on normal blood cells." | 7.76 | The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters. ( Cloonan, SM; Drozgowska, A; Fayne, D; Williams, DC, 2010) |
| " We report that the SSRI fluoxetine and the NSRI maprotiline are potent antiproliferative agents against human Burkitt lymphoma (BL), having little effect on normal blood cells." | 3.76 | The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters. ( Cloonan, SM; Drozgowska, A; Fayne, D; Williams, DC, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McNamara, YM | 1 |
| Bright, SA | 1 |
| Byrne, AJ | 1 |
| Cloonan, SM | 3 |
| McCabe, T | 1 |
| Williams, DC | 3 |
| Meegan, MJ | 1 |
| Drozgowska, A | 1 |
| Fayne, D | 1 |
3 other studies available for maprotiline and Burkitt Lymphoma
| Article | Year |
|---|---|
Synthesis and antiproliferative action of a novel series of maprotiline analogues.
Topics: Adrenergic Uptake Inhibitors; Antineoplastic Agents; Apoptosis; Burkitt Lymphoma; Cell Line, Tumor; | 2014 |
The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters.
Topics: Animals; Antidepressive Agents; Apoptosis; Burkitt Lymphoma; Cell Line, Tumor; Cell Proliferation; D | 2010 |
The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma.
Topics: Antidepressive Agents, Second-Generation; Apoptosis; Autophagy; bcl-2 Homologous Antagonist-Killer P | 2011 |