maoecrystal-a and Lung-Neoplasms

maoecrystal-a has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for maoecrystal-a and Lung-Neoplasms

ArticleYear
Cytotoxic 3,20-epoxy-ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora.
    Journal of natural products, 2002, Volume: 65, Issue:12

    Four new ent-kaurane diterpenoids, laxiflorins J-M (1-4), along with maoecrystal A (5) and maoecrystal P (6), were isolated from the leaves of Isodon eriocalyx var. laxiflora. Their structures were determined by spectroscopic analyses. All the compounds were assayed for their cytotoxic effects on human tumor K562, A549, and T24 cell lines. Compounds 1 and 6 showed significant inhibitory effects on human tumor K562 and T24 cells, with IC(50) values less than 0.5 microg/mL. Compound 3 also demonstrated cytotoxic activities against all three types of human tumor cells, with IC(50) values in the range of 1-25 microg/mL.

    Topics: Antineoplastic Agents, Phytogenic; China; Diterpenes; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Isodon; K562 Cells; Lung Neoplasms; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Leaves; Plants, Medicinal; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured

2002