manzamine-a and Lung-Neoplasms

manzamine-a has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for manzamine-a and Lung-Neoplasms

Article	Year
PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric β-carboline. Bioorganic & medicinal chemistry letters, 2016, 10-15, Volume: 26, Issue:20 Dimeric β-carbolines are cytotoxic against multiple NSCLC cell lines, and we report herein our preliminary studies on the mechanism of action of these dimeric structures. Dimeric β-carboline 1, which is more potent than the corresponding monomer in NSCLC cell lines, is a lysosomotropic agent that inhibits autophagy and mediates cell death by apoptosis, upregulating the pro-apoptotic BH3-only protein PUMA (p53 upregulated modulator of apoptosis) in a dose dependent manner. Topics: Apoptosis; Apoptosis Regulatory Proteins; Carbolines; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dimerization; Humans; Lung Neoplasms; Proto-Oncogene Proteins	2016

Article

Year

PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric β-carboline.

Bioorganic & medicinal chemistry letters, 2016, 10-15, Volume: 26, Issue:20

Dimeric β-carbolines are cytotoxic against multiple NSCLC cell lines, and we report herein our preliminary studies on the mechanism of action of these dimeric structures. Dimeric β-carboline 1, which is more potent than the corresponding monomer in NSCLC cell lines, is a lysosomotropic agent that inhibits autophagy and mediates cell death by apoptosis, upregulating the pro-apoptotic BH3-only protein PUMA (p53 upregulated modulator of apoptosis) in a dose dependent manner.

Topics: Apoptosis; Apoptosis Regulatory Proteins; Carbolines; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dimerization; Humans; Lung Neoplasms; Proto-Oncogene Proteins

2016