manzamine-a and Leukemia-P388

manzamine-a has been researched along with Leukemia-P388* in 2 studies

Other Studies

2 other study(ies) available for manzamine-a and Leukemia-P388

Article	Year
8-Hydroxymanzamine A, a beta-carboline alkaloid from a sponge, Pachypellina sp. Journal of natural products, 1994, Volume: 57, Issue:1 The previously described manzamine A [1] and the new 8-hydroxymanzamine A [2] were isolated from an undescribed sponge, Pachypellina sp. Both compounds exhibit moderate antitumor and anti-HSV-II activity. Topics: Animals; Antineoplastic Agents; Antiviral Agents; Carbolines; Drug Screening Assays, Antitumor; Herpesvirus 2, Human; Humans; KB Cells; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Porifera; Spectrophotometry, Ultraviolet	1994
Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity. Journal of natural products, 1993, Volume: 56, Issue:6 Twenty-four metabolites derived from marine sponges were evaluated for their cytotoxicities against two human tumor cell lines, non-small cell lung carcinoma A549 and colon adenocarcinoma HT-29, and against one murine leukemia cell line, P-388, and evaluated for their ability to effect signal transduction in a newly developed cell adhesion assay using an EL-4 cell line. The compounds included latrunculin A [1], batzelline A [2], chondrillin [3], aureol [4], epihippuristanol, theonellamine B, discorhabdins A and C, kabiramide C, dercitin, meridine, manzamines A, B, and C, 8,15-diisocyano-11(20)-amphilectene and the corresponding C-15 formamide, a 20-carbon acetylenic alcohol, 4,5-dihydro-6"-deoxybromotopsentin, epispongiadiol, isospongiadiol, puupehenone, reiswigin A, and demethyl- and demethyloxyaaptamine. Latrunculin A [1], batzelline A [2], chondrillin [3], and aureol [4] expressed the desired profile of a greater than five-fold level of cytotoxicity against A549 relative to P-388, and an effect in the cell adhesion assay. In this group of compounds, cytotoxicity toward A549 was equal to or more pronounced than against HT-29. Latrunculin A was evaluated in an sc-implanted human A549 lung tumor xenograft mouse model and yielded a T/C of 146%. Batzelline A was evaluated in the cancer cell line panel at the National Cancer Institute and found to express selective cytotoxicity against several melanoma cancer cell lines. Topics: Animals; Antineoplastic Agents; Cell Adhesion; Cell Division; Humans; Leukemia P388; Mice; Porifera; Protein Kinase C; Signal Transduction; Tumor Cells, Cultured	1993

Article

Year

8-Hydroxymanzamine A, a beta-carboline alkaloid from a sponge, Pachypellina sp.

Journal of natural products, 1994, Volume: 57, Issue:1

The previously described manzamine A [1] and the new 8-hydroxymanzamine A [2] were isolated from an undescribed sponge, Pachypellina sp. Both compounds exhibit moderate antitumor and anti-HSV-II activity.

Topics: Animals; Antineoplastic Agents; Antiviral Agents; Carbolines; Drug Screening Assays, Antitumor; Herpesvirus 2, Human; Humans; KB Cells; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Porifera; Spectrophotometry, Ultraviolet

1994

Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity.

Journal of natural products, 1993, Volume: 56, Issue:6

Twenty-four metabolites derived from marine sponges were evaluated for their cytotoxicities against two human tumor cell lines, non-small cell lung carcinoma A549 and colon adenocarcinoma HT-29, and against one murine leukemia cell line, P-388, and evaluated for their ability to effect signal transduction in a newly developed cell adhesion assay using an EL-4 cell line. The compounds included latrunculin A [1], batzelline A [2], chondrillin [3], aureol [4], epihippuristanol, theonellamine B, discorhabdins A and C, kabiramide C, dercitin, meridine, manzamines A, B, and C, 8,15-diisocyano-11(20)-amphilectene and the corresponding C-15 formamide, a 20-carbon acetylenic alcohol, 4,5-dihydro-6"-deoxybromotopsentin, epispongiadiol, isospongiadiol, puupehenone, reiswigin A, and demethyl- and demethyloxyaaptamine. Latrunculin A [1], batzelline A [2], chondrillin [3], and aureol [4] expressed the desired profile of a greater than five-fold level of cytotoxicity against A549 relative to P-388, and an effect in the cell adhesion assay. In this group of compounds, cytotoxicity toward A549 was equal to or more pronounced than against HT-29. Latrunculin A was evaluated in an sc-implanted human A549 lung tumor xenograft mouse model and yielded a T/C of 146%. Batzelline A was evaluated in the cancer cell line panel at the National Cancer Institute and found to express selective cytotoxicity against several melanoma cancer cell lines.

Topics: Animals; Antineoplastic Agents; Cell Adhesion; Cell Division; Humans; Leukemia P388; Mice; Porifera; Protein Kinase C; Signal Transduction; Tumor Cells, Cultured

1993