manumycin and Neuroblastoma

manumycin has been researched along with Neuroblastoma* in 1 studies

Other Studies

1 other study(ies) available for manumycin and Neuroblastoma

Article	Year
GDNF-induced neurite formation was stimulated by protein kinase inhibitors and suppressed by Ras inhibitors. Neuroscience letters, 1997, Dec-05, Volume: 238, Issue:3 The effects of various inhibitors on the glial cell line-derived neurotrophic factor (GDNF)-induced neurite formation in TGW human neuroblastoma cells were investigated. Treatment of cells with Ser/Thr protein kinase inhibitors such as staurosporine, H-7, H-8 and HA-1004, induced neurite formation without GDNF. On the other hand, tyrosine kinase inhibitors such as erbstatin, genistein and herbimycin A did not produce neurites per se, but effectively enhanced the GDNF-induced neurite formation. A phosphatase inhibitor, okadaic acid, and Ras inhibitors such as oxanosine, damnacanthal and conophylline strongly suppressed the effect of GDNF. These results suggest that a tyrosine protein kinase has a suppressive role in the neurite formation induced by GDNF and that Ras is necessary for the signaling initiated by GDNF. Topics: Enzyme Inhibitors; Glial Cell Line-Derived Neurotrophic Factor; Humans; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neuroblastoma; Neuroprotective Agents; Polyenes; Polyunsaturated Alkamides; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Staurosporine; Tumor Cells, Cultured	1997

Article

Year

GDNF-induced neurite formation was stimulated by protein kinase inhibitors and suppressed by Ras inhibitors.

Neuroscience letters, 1997, Dec-05, Volume: 238, Issue:3

The effects of various inhibitors on the glial cell line-derived neurotrophic factor (GDNF)-induced neurite formation in TGW human neuroblastoma cells were investigated. Treatment of cells with Ser/Thr protein kinase inhibitors such as staurosporine, H-7, H-8 and HA-1004, induced neurite formation without GDNF. On the other hand, tyrosine kinase inhibitors such as erbstatin, genistein and herbimycin A did not produce neurites per se, but effectively enhanced the GDNF-induced neurite formation. A phosphatase inhibitor, okadaic acid, and Ras inhibitors such as oxanosine, damnacanthal and conophylline strongly suppressed the effect of GDNF. These results suggest that a tyrosine protein kinase has a suppressive role in the neurite formation induced by GDNF and that Ras is necessary for the signaling initiated by GDNF.

Topics: Enzyme Inhibitors; Glial Cell Line-Derived Neurotrophic Factor; Humans; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neuroblastoma; Neuroprotective Agents; Polyenes; Polyunsaturated Alkamides; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Staurosporine; Tumor Cells, Cultured

1997