mansonone-g and Ovarian-Neoplasms

mansonone-g has been researched along with Ovarian-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for mansonone-g and Ovarian-Neoplasms

Article	Year
Isolation and synthesis of two antiproliferative calamenene-type sesquiterpenoids from Sterculia tavia from the Madagascar rain forest. Bioorganic & medicinal chemistry, 2012, Dec-15, Volume: 20, Issue:24 Investigation of the endemic Madagascan plant Sterculia taiva Baill. (Malvaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of two new bioactive calamenene-type sesquiterpenoids, named tavinin A (2) and epi-tavinin A (3) together with the known sesquiterpenoid mansonone G (1). The structures of the two new compounds were elucidated based on analysis of their 1D and 2D NMR spectra and mass spectrometric data, and were confirmed by de novo synthesis. The three isolated sesquiterpenoids (1-3) had modest antiproliferative activities against the A2780 ovarian cancer cell line, with IC(50) values of 10.2, 5.5 and 6.7 μM, respectively. Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Madagascar; Ovarian Neoplasms; Plant Extracts; Polycyclic Sesquiterpenes; Sesquiterpenes; Sterculia; Terpenes	2012

Article

Year

Isolation and synthesis of two antiproliferative calamenene-type sesquiterpenoids from Sterculia tavia from the Madagascar rain forest.

Bioorganic & medicinal chemistry, 2012, Dec-15, Volume: 20, Issue:24

Investigation of the endemic Madagascan plant Sterculia taiva Baill. (Malvaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of two new bioactive calamenene-type sesquiterpenoids, named tavinin A (2) and epi-tavinin A (3) together with the known sesquiterpenoid mansonone G (1). The structures of the two new compounds were elucidated based on analysis of their 1D and 2D NMR spectra and mass spectrometric data, and were confirmed by de novo synthesis. The three isolated sesquiterpenoids (1-3) had modest antiproliferative activities against the A2780 ovarian cancer cell line, with IC(50) values of 10.2, 5.5 and 6.7 μM, respectively.

Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Madagascar; Ovarian Neoplasms; Plant Extracts; Polycyclic Sesquiterpenes; Sesquiterpenes; Sterculia; Terpenes

2012