mannuronic acid has been researched along with Rheumatoid Arthritis in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 7 (46.67) | 2.80 |
| Authors | Studies |
|---|---|
| Abbasi, S; Aghazadeh, Z; Ahmadzadeh, A; Aslani, M; Hosseini, M; Mirshafiey, A; Omidian, S | 1 |
| Aghazadeh, Z; Ahmadzadeh, A; Aslani, M; Hosseini, M; Mirshafiey, A; Sharifi, L; Zaki-Dizaji, M | 1 |
| Ahmadzadeh, A; Aslani, M; Mirshafiey, A; Mortazavi-Jahromi, SS; Omidian, S; Rezaieyazdi, Z | 2 |
| Ahmadzadeh, A; Aslani, M; Barati, A; Hosseini, M; Mirshafiey, A; Mortazavi-Jahromi, SS; Rezaieyazdi, Z | 1 |
| Aghazadeh, Z; Aslani, M; Gaafar, NAG; Mirshafiey, A; Mortazavi-Jahromi, SS; Razavi, A | 1 |
| Ahmadi, H; Barati, A; Cuzzocrea, S; Fattahi, MJ; Jamshidi, AR; Mahmoudi, M; Matsuo, H; Mirshafiey, A; Rehm, BHA | 1 |
| Aghazadeh, Z; Ahmadi, H; Barati, A; Jamshidi, AR; Mirshafiey, A | 1 |
| Ahmadi, H; Barati, A; Gharibdoost, F; Jamshidi, AR; Mahmoudi, M; Mirshafiey, A; Vojdanian, M | 1 |
| Aghazadeh, Z; Ahmadi, H; Barati, A; Fattahi, MJ; Gharibdoost, F; Jamshidi, AR; Mahmoudi, M; Mirshafiey, A; Vojdanian, M | 1 |
| Aghazadeh, Z; Ahmadi, H; Fattahi, MJ; Gharibdoost, F; Jamshidi, AR; Mahmoudi, M; Mirshafiey, A; Rastkari, N; Vojdanian, M | 1 |
| Ahmadi, H; Babaloo, Z; Jahanbakhshi, M; Mirshafiey, A; Mortazavi-Jahromi, SS; Shokri, MM | 1 |
| Aghazadeh, Z; Ahmadi, H; Cuzzocrea, S; Fattahi, MJ; Gharibdoost, F; Hosseini, M; Jamshidi, AR; Mahmoudi, M; Matsuo, H; Mirshafiey, A; Mortazavi-Jahromi, SS; Mostafaei, S; Rastkari, N; Rehm, BHA; Vojdanian, M | 1 |
| Aghazadeh, Z; Ahmadzadeh, A; Aslani, M; Cuzzocrea, S; D'Aniello, A; Ekhtiari, P; Fallahzadeh, H; Farooqi, A; Hosseini, M; Khodashahi, M; Matsuo, H; Mirshafiey, A; Mortazavi-Jahromi, SS; Omidian, S; Rehm, BHA; Rezaieyazdi, Z; Sadoughi, A; Soleymani-Salehabadi, H; Vahidi, Z; Zamurrad, S | 1 |
| Aghazadeh, Z; Aslani, M; Gaafar, NAG; Mirshafiey, A; Razavi, A | 1 |
8 trial(s) available for mannuronic acid and Rheumatoid Arthritis
| Article | Year |
|---|---|
Immunopharmacological effect of β-d-mannuronic acid (M2000), as a new immunosuppressive drug, on gene expression of miR-155 and its target molecules (SOCS1, SHIP1) in a clinical trial on rheumatoid arthritis patients.
Topics: Administration, Oral; Adolescent; Adult; Aged; Arthritis, Rheumatoid; Female; Gene Expression Regulation; Hexuronic Acids; Humans; Immunosuppressive Agents; Male; MicroRNAs; Middle Aged; NF-kappa B; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Suppressor of Cytokine Signaling 1 Protein; Young Adult | 2020 |
The role of β-d-mannuronic acid, as a new non-steroidal anti-inflammatory drug on expression of miR-146a, IRAK1, TRAF6, NF-κB and pro-inflammatory cytokines following a clinical trial in rheumatoid arthritis patients.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cytokines; Female; Hexuronic Acids; Humans; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intracellular Signaling Peptides and Proteins; Male; MicroRNAs; Middle Aged; NF-kappa B; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2020 |
The Potent Inhibitory Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property on Anti-Cyclic Citrullinated Peptide Antibodies, Rheumatoid Factor and Anti-dsDNA Antibodies in Patients with Rheumatoid Arthritis.
Topics: Adult; Aged; Anti-Citrullinated Protein Antibodies; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinuclear; Arthritis, Rheumatoid; C-Reactive Protein; Female; Hexuronic Acids; Humans; Immunosuppressive Agents; Male; Middle Aged; Rheumatoid Factor | 2017 |
Targeting of circulating Th17 cells by β-D-mannuronic acid (M2000) as a novel medication in patients with rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cytokines; Etanercept; Female; Hexuronic Acids; Humans; Interleukin-17; Male; Middle Aged; Th17 Cells; Tumor Necrosis Factor-alpha | 2018 |
Modification of Sexual Hormones in Rheumatoid Arthritis Patients by M2000 (β-D-mannuronic Acid) as a Novel NSAID with Immunosuppressive Property.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dehydroepiandrosterone Sulfate; Estradiol; Female; Hexuronic Acids; Humans; Immunosuppressive Agents; Male; Middle Aged; Progesterone; Time Factors; Treatment Outcome; Up-Regulation | 2018 |
A phase I/II randomized, controlled, clinical trial for assessment of the efficacy and safety of β-D-mannuronic acid in rheumatoid arthritis patients.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Hexuronic Acids; Humans; Male; Middle Aged; Treatment Outcome | 2018 |
International multicenter randomized, placebo-controlled phase III clinical trial of β-D-mannuronic acid in rheumatoid arthritis patients.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Hexuronic Acids; Humans; Male; Middle Aged; Severity of Illness Index; Treatment Outcome | 2019 |
The Oral Administration Effect of Drug Mannuronic Acid (M2000) on Gene Expression of Matrix and Tissue Inhibitor of Metalloproteinases in Rheumatoid Arthritis Patients.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Gene Expression Regulation; Healthy Volunteers; Hexuronic Acids; Humans; Immunosuppressive Agents; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Tissue Inhibitor of Metalloproteinase-2; Treatment Outcome | 2020 |
7 other study(ies) available for mannuronic acid and Rheumatoid Arthritis
| Article | Year |
|---|---|
Evaluating Mannuronic Acid Effect on Gene Expression Profile of Inflammatory Mediators in Rheumatoid Arthritis Patients.
Topics: Arthritis, Rheumatoid; Diclofenac; Hexuronic Acids; Humans; Inflammation Mediators; Interleukin-22; Interleukin-6; Interleukins; Leukocytes, Mononuclear; Myeloid Differentiation Factor 88; Toll-Like Receptor 2; Transcriptome; Tumor Necrosis Factor-alpha | 2022 |
Influence of β-D-mannuronic Acid, as a New Member of Non-steroidal Anti- Inflammatory Drugs Family, on the Expression Pattern of Chemokines and their Receptors in Rheumatoid Arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cells, Cultured; Chemokine CCL2; Diclofenac; Dose-Response Relationship, Drug; Down-Regulation; Female; Gene Expression Profiling; Hexuronic Acids; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Receptors, Chemokine; Receptors, CXCR4; Synovial Membrane | 2021 |
The Situation of Chemokine Ligands and Receptors Gene Expression, Following the Oral Administration of Drug Mannuronic Acid in Rheumatoid Arthritis Patients.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemokines; Female; Gene Expression Regulation; Hexuronic Acids; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Patents as Topic; Receptors, Chemokine; Young Adult | 2020 |
Effects of mannuronic acid (M2000) on gene expression profile of signal transducer and activator of transcription proteins (STATs) in rheumatoid arthritis patients.
Topics: Administration, Oral; Arthritis, Rheumatoid; Female; Hexuronic Acids; Humans; Male; Middle Aged; STAT Transcription Factors; Transcriptome | 2020 |
Effects of β-d-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Rheumatoid; Female; GATA3 Transcription Factor; Gene Expression Profiling; Hexuronic Acids; Humans; Immunosuppressive Agents; Interleukin-17; Interleukin-4; Male; Middle Aged; Nuclear Receptor Subfamily 1, Group F, Member 3 | 2017 |
The Anti-Migraine Effects of M2000 (β-D-Mannuronic Acid) on a Patient with Rheumatoid Arthritis: Case Report.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Hexuronic Acids; Humans; Immunosuppressive Agents; Migraine Disorders; Severity of Illness Index; Treatment Outcome | 2017 |
Hematological Improvement of Patients with Active Rheumatoid Arthritis by β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biomarkers; Cytokines; Erythrocyte Indices; Female; Hexuronic Acids; Humans; Immunosuppressive Agents; Inflammation Mediators; Leukocyte Count; Male; Middle Aged; Treatment Outcome | 2017 |