mannich-bases and Ovarian-Neoplasms

mannich-bases has been researched along with Ovarian-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for mannich-bases and Ovarian-Neoplasms

Article	Year
In Vitro Anticancer Activity of Novel Ciprofloxacin Mannich Base in Lung Adenocarcinoma and High-Grade Serous Ovarian Cancer Cell Lines via Attenuating MAPK Signaling Pathway. Molecules (Basel, Switzerland), 2023, Jan-23, Volume: 28, Issue:3 Topics: Adenocarcinoma of Lung; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Ciprofloxacin; Female; Humans; Lung Neoplasms; Mannich Bases; Ovarian Neoplasms; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Tumor Suppressor Protein p53	2023
Synthesis of kaempferide Mannich base derivatives and their antiproliferative activity on three human cancer cell lines. Acta biochimica Polonica, 2015, Volume: 62, Issue:3 Kaempferide (3,5,7-trihydroxy-4'-methoxyflavone, 1), a naturally occurring flavonoid with potent anticancer activity in a number of human tumour cell lines, was first semisynthesized from naringin. Based on Mannich reaction of kaempferide with various secondary amines and formaldehyde, nine novel kaempferide Mannich base derivatives 2-10 were synthesized. The aminomethylation occurred preferentially in the position at C-6 and C-8 of the A-ring of kaempferide. All the synthetic compounds were tested for antiproliferative activity against three human cancer cell lines (Hela, HCC1954, SK-OV-3) by the standard MTT method. The results showed that compounds 1, 2 and 5-10 were more potent against Hela cells with IC50 values of 12.47-28.24 μM than the positive control cis-platin (IC50 41.25 μM), compounds 5, 6, 8 and 10 were more potent against HCC1954 cells with IC50 values of 8.82-14.97 μM than the positive control cis-platin (IC50 29.68 μM), and compounds 2, 3, 5, 6 and 10 were more potent against SK-OV-3 cells with IC50 values of 7.67-18.50 μM than the positive control cis-platin (IC50 21.27 μM). Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cisplatin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; Inhibitory Concentration 50; Kaempferols; Mannich Bases; Models, Chemical; Ovarian Neoplasms; Temperature; Uterine Cervical Neoplasms	2015

Article

Year

In Vitro Anticancer Activity of Novel Ciprofloxacin Mannich Base in Lung Adenocarcinoma and High-Grade Serous Ovarian Cancer Cell Lines via Attenuating MAPK Signaling Pathway.

Molecules (Basel, Switzerland), 2023, Jan-23, Volume: 28, Issue:3

Topics: Adenocarcinoma of Lung; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Ciprofloxacin; Female; Humans; Lung Neoplasms; Mannich Bases; Ovarian Neoplasms; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Tumor Suppressor Protein p53

2023

Synthesis of kaempferide Mannich base derivatives and their antiproliferative activity on three human cancer cell lines.

Acta biochimica Polonica, 2015, Volume: 62, Issue:3

Kaempferide (3,5,7-trihydroxy-4'-methoxyflavone, 1), a naturally occurring flavonoid with potent anticancer activity in a number of human tumour cell lines, was first semisynthesized from naringin. Based on Mannich reaction of kaempferide with various secondary amines and formaldehyde, nine novel kaempferide Mannich base derivatives 2-10 were synthesized. The aminomethylation occurred preferentially in the position at C-6 and C-8 of the A-ring of kaempferide. All the synthetic compounds were tested for antiproliferative activity against three human cancer cell lines (Hela, HCC1954, SK-OV-3) by the standard MTT method. The results showed that compounds 1, 2 and 5-10 were more potent against Hela cells with IC50 values of 12.47-28.24 μM than the positive control cis-platin (IC50 41.25 μM), compounds 5, 6, 8 and 10 were more potent against HCC1954 cells with IC50 values of 8.82-14.97 μM than the positive control cis-platin (IC50 29.68 μM), and compounds 2, 3, 5, 6 and 10 were more potent against SK-OV-3 cells with IC50 values of 7.67-18.50 μM than the positive control cis-platin (IC50 21.27 μM).

Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cisplatin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; Inhibitory Concentration 50; Kaempferols; Mannich Bases; Models, Chemical; Ovarian Neoplasms; Temperature; Uterine Cervical Neoplasms

2015