manidipine has been researched along with Diabetic Nephropathies in 5 studies
Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to investigate the effect of delapril, an ACE inhibitor, and manidipine, a long action calcium antagonist, on persistent microalbuminuria in normotensive type 2 diabetic patients." | 9.09 | Effects on urinary albumin excretion and renal function changes by delapril and manidipine in normotensive type 2 diabetic patients with microalbuminuria. ( Deerochanawong, C; Kornthong, P; Phongwiratchai, S; Serirat, S, 2001) |
| "The open trial was designed to evaluate the effects of long-term antihypertensive treatment with the calcium-channel blocker, manidipine and the angiotensin converting enzyme (ACE) inhibitor, delapril on insulin sensitivity in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients with essential hypertension." | 7.69 | Effect of manidipine and delapril on insulin sensitivity in type 2 diabetic patients with essential hypertension. ( Akai, H; Hinokio, Y; Hirai, A; Hirai, M; Hirai, S; Kawasaki, H; Ohtomo, M; Onoda, M; Satoh, Y; Suzuki, S; Toyota, T, 1996) |
| "Manidipine plus delapril is a fixed-dose combination of a third-generation dihydropyridine calcium antagonist and an angiotensin-converting enzyme inhibitor, which is effective in mild-to-moderately hypertensive patients with an inadequate response to monotherapy." | 6.44 | Manidipine plus delapril in patients with Type 2 diabetes and hypertension: reducing cardiovascular risk and end-organ damage. ( Coca, A, 2007) |
| "This study was designed to investigate the effect of delapril, an ACE inhibitor, and manidipine, a long action calcium antagonist, on persistent microalbuminuria in normotensive type 2 diabetic patients." | 5.09 | Effects on urinary albumin excretion and renal function changes by delapril and manidipine in normotensive type 2 diabetic patients with microalbuminuria. ( Deerochanawong, C; Kornthong, P; Phongwiratchai, S; Serirat, S, 2001) |
| "The open trial was designed to evaluate the effects of long-term antihypertensive treatment with the calcium-channel blocker, manidipine and the angiotensin converting enzyme (ACE) inhibitor, delapril on insulin sensitivity in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients with essential hypertension." | 3.69 | Effect of manidipine and delapril on insulin sensitivity in type 2 diabetic patients with essential hypertension. ( Akai, H; Hinokio, Y; Hirai, A; Hirai, M; Hirai, S; Kawasaki, H; Ohtomo, M; Onoda, M; Satoh, Y; Suzuki, S; Toyota, T, 1996) |
| "Thirty-nine hypertensive patients with type 2 diabetes mellitus were followed under long-term treatment (mean, 20." | 2.69 | Delapril versus manidipine in hypertensive therapy to halt the type-2-diabetes-mellitus-associated nephropathy. ( Fujita, R; Hayashi, Y; Inoue, M; Iwamoto, Y; Kageyama, S; Kitamura, S; Makino, F; Okuda, Y; Shiba, T; Tada, H; Takahasi, C, 2000) |
| "Manidipine plus delapril is a fixed-dose combination of a third-generation dihydropyridine calcium antagonist and an angiotensin-converting enzyme inhibitor, which is effective in mild-to-moderately hypertensive patients with an inadequate response to monotherapy." | 2.44 | Manidipine plus delapril in patients with Type 2 diabetes and hypertension: reducing cardiovascular risk and end-organ damage. ( Coca, A, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruggenenti, P | 1 |
| Lauria, G | 1 |
| Iliev, IP | 1 |
| Fassi, A | 1 |
| Ilieva, AP | 1 |
| Rota, S | 1 |
| Chiurchiu, C | 1 |
| Barlovic, DP | 1 |
| Sghirlanzoni, A | 1 |
| Lombardi, R | 1 |
| Penza, P | 1 |
| Cavaletti, G | 1 |
| Piatti, ML | 1 |
| Frigeni, B | 1 |
| Filipponi, M | 1 |
| Rubis, N | 1 |
| Noris, G | 1 |
| Motterlini, N | 1 |
| Ene-Iordache, B | 1 |
| Gaspari, F | 1 |
| Perna, A | 1 |
| Zaletel, J | 1 |
| Bossi, A | 1 |
| Dodesini, AR | 1 |
| Trevisan, R | 1 |
| Remuzzi, G | 1 |
| Coca, A | 1 |
| Suzuki, S | 1 |
| Ohtomo, M | 1 |
| Satoh, Y | 1 |
| Kawasaki, H | 1 |
| Hirai, M | 1 |
| Hirai, A | 1 |
| Hirai, S | 1 |
| Onoda, M | 1 |
| Hinokio, Y | 1 |
| Akai, H | 1 |
| Toyota, T | 1 |
| Shiba, T | 1 |
| Inoue, M | 1 |
| Tada, H | 1 |
| Hayashi, Y | 1 |
| Okuda, Y | 1 |
| Fujita, R | 1 |
| Makino, F | 1 |
| Takahasi, C | 1 |
| Kageyama, S | 1 |
| Kitamura, S | 1 |
| Iwamoto, Y | 1 |
| Deerochanawong, C | 1 |
| Kornthong, P | 1 |
| Phongwiratchai, S | 1 |
| Serirat, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Randomized, Prospective, Double-blind Study to Evaluate the Nephroprotective Effect of Delapril Alone or Combined With Manidipine in Patients With Type 2 Diabetes[NCT00157586] | Phase 3 | 342 participants | Interventional | 2002-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for manidipine and Diabetic Nephropathies
| Article | Year |
|---|---|
Manidipine plus delapril in patients with Type 2 diabetes and hypertension: reducing cardiovascular risk and end-organ damage.
Topics: Blood Pressure Determination; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropat | 2007 |
3 trials available for manidipine and Diabetic Nephropathies
| Article | Year |
|---|---|
Effects of manidipine and delapril in hypertensive patients with type 2 diabetes mellitus: the delapril and manidipine for nephroprotection in diabetes (DEMAND) randomized clinical trial.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Body Mass Index; Calcium Chann | 2011 |
Delapril versus manidipine in hypertensive therapy to halt the type-2-diabetes-mellitus-associated nephropathy.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calc | 2000 |
Effects on urinary albumin excretion and renal function changes by delapril and manidipine in normotensive type 2 diabetic patients with microalbuminuria.
Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Diabet | 2001 |
1 other study available for manidipine and Diabetic Nephropathies
| Article | Year |
|---|---|
Effect of manidipine and delapril on insulin sensitivity in type 2 diabetic patients with essential hypertension.
Topics: Antihypertensive Agents; Blood Glucose; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Diabeti | 1996 |