mangostin and Glioblastoma

mangostin has been researched along with Glioblastoma* in 1 studies

Other Studies

1 other study(ies) available for mangostin and Glioblastoma

ArticleYear
α-Mangostin, a dietary xanthone, induces autophagic cell death by activating the AMP-activated protein kinase pathway in glioblastoma cells.
    Journal of agricultural and food chemistry, 2011, Mar-09, Volume: 59, Issue:5

    This study is the first to investigate the anticancer effects of α-mangostin in human glioblastoma cells. α-Mangostin decreases cell viability by inducing autophagic cell death but not apoptosis. Pretreatment of cells with the autophagy inhibitors 3-methyladenine (3-MA) and bafilomycin or knockdown beclin-1, resulted in the suppression of α-mangostin-mediated cell death. We also found that liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) signaling is a critical mediator of α-mangostin-induced inhibition of cell growth. Activation of AMPK induces α-mangostin-mediated phosphorylation of raptor, which subsequently associates with 14-3-3γ and results in the loss of mTORC1 activity. The phosphorylation of both downstream targets of mTORC1, p70 ribosomal protein S6 kinase (p70S6 kinase) and 4E-BP1, is also diminished by activation of AMPK. Furthermore, the inhibition of AMPK expression with shRNAs or an inhibitor of AMPK reduced α-mangostin-induced autophagy and raptor phosphorylation, supporting the theory that activation of AMPK is beneficial to autophagy. A further investigation revealed that α-mangostin also induced autophagic cell death in transplanted glioblastoma in nude mice. Together, these results suggest a critical role for AMPK activation in the α-mangostin-induced autophagy of human glioblastoma cells.

    Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Phytogenic; Autophagy; Cell Line, Tumor; Cell Survival; Enzyme Activation; Glioblastoma; Humans; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Nude; Multiprotein Complexes; Neoplasm Transplantation; Phosphorylation; Proteins; Regulatory-Associated Protein of mTOR; TOR Serine-Threonine Kinases; Xanthones

2011