Page last updated: 2024-08-22

manganese and Huntington Disease

manganese has been researched along with Huntington Disease in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19903 (12.00)18.7374
1990's0 (0.00)18.2507
2000's1 (4.00)29.6817
2010's12 (48.00)24.3611
2020's9 (36.00)2.80

Authors

AuthorsStudies
Bowman, AB; Cox, EC; Debbiche, IF; Erikson, KM; Harrison, FE; Pfalzer, AC; Tienda, AA; Totten, MS; Wilcox, JM1
Bowman, AB; Calipari, ES; Consoli, DC; Harrison, FE; Paffenroth, KC; Spitznagel, BD; Wilcox, JM1
Bowman, AB; Claassen, DO; Erikson, K; Kang, H; Pfalzer, AC; Silverman, J; Totten, M; Yan, Y1
Clares, MP; García-España, E; Merino, M; Mullor, JL; Sánchez-Sánchez, AV; Sequedo, MD; Vázquez-Manrique, RP1
Boudi, A; Chhetri, G; DiFiglia, M; Ghosh, A; Islam, MA; Ke, Y; Li, X; Li, Y; Sapp, E; Usman, M; Wang, J; Wang, P; Wang, X1
Huang, EJ; Marsan, E1
Cooper, GJS; Patassini, S; Scholefield, M; Xu, J1
Aschner, M; Bodnya, C; Bowman, AB; Ilieva, I; Joshi, P; Neely, MD1
Aschner, M; Bowman, AB; Bryan, MR; Di Pardo, A; Foshage, AM; Joshi, P; Maglione, V; Nitin, R; Nordham, KD; O'Brien, MT; Rose, DIR; Uhouse, MA; Zhang, Z1
Aschner, M; Bichell, TJV; Bowman, AB; Codreanu, SG; Erikson, KM; Halbesma, T; Harrison, FE; McLean, JA; Parmalee, NL; Pfalzer, AC; Sherrod, SD; Totten, M; Umashanker, P; Wilcox, JM; Yang, KL1
Aschner, M; Bowman, AB; Bryan, MR; Hardeman, KN; Morcillo, P; Warren, EB1
Bowman, AB; Bryan, MR1
Bowman, AB; Pfalzer, AC; Porter, NA; Wages, PA1
Aboud, AA; Aschner, M; Bowman, AB; Bryan, MR; Ess, KC; Feist, JE; Kumar, KK; Neely, MD; Tidball, AM; Uhouse, MA1
Aschner, M; Bornhorst, J; Bowman, AB; Goodwin, CR; Kumar, KK; McLean, JA; Schwerdtle, T; Uhouse, MA1
Aschner, M; Bowman, AB; Caito, SW; Horning, KJ; Tipps, KG1
Aschner, M; Bichell, TJV; Bowman, AB; Bradley, EM; Bryan, M; Colbran, RJ; Di Pardo, A; Dudek, K; Fisher, N; Halbesma, T; Holt, HK; Horning, K; Kwakye, GF; Maglione, V; Neely, MD; Osmand, A; Stubbs, AD; Tidball, AM; Tipps, KG; Uhouse, MA; Umashanker, P; Wegrzynowicz, M1
Anderson, JG; Aschner, M; Bowman, AB; Erikson, KM; Kwakye, GF; Li, D; Vadodaria, BK; Wegrzynowicz, M; Williams, BB1
Aschner, M; Bowman, AB; Erikson, KM; Kwakye, GF; Li, D; Wegrzynowicz, M; Williams, BB1
Bowman, AB; Kwakye, GF; Li, D1
Aschner, M; Bowman, AB; Madison, JL; Wegrzynowicz, M1
Norenberg, MD; Rao, KV1
Borisova, TV1
Cotzias, GC; Gellene, R; Papavasiliou, PS1
Bird, ED; Heathfield, KW; Pilling, JB1

Reviews

3 review(s) available for manganese and Huntington Disease

ArticleYear
Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders.
    Advances in neurobiology, 2017, Volume: 18

    Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Autophagy; Brain; Disease Models, Animal; Humans; Huntingtin Protein; Huntington Disease; Insulin; Manganese; Mitochondria; Neostriatum; Neural Stem Cells; Neurodegenerative Diseases; Parkinson Disease; Reactive Oxygen Species; Signal Transduction; Somatomedins

2017
Manganese Is Essential for Neuronal Health.
    Annual review of nutrition, 2015, Volume: 35

    Topics: Arginase; Bile; Blood-Brain Barrier; Brain; Enzyme Activation; Glutamate-Ammonia Ligase; Health Status; Homeostasis; Humans; Huntington Disease; Intestinal Absorption; Manganese; Nervous System Diseases; Neurons; Parkinson Disease

2015
The mitochondrial permeability transition in neurologic disease.
    Neurochemistry international, 2007, Volume: 50, Issue:7-8

    Topics: Alzheimer Disease; Calcium; Energy Metabolism; Humans; Huntington Disease; Hyperglycemia; Manganese; Mitochondrial Membranes; Mitochondrial Swelling; Motor Neuron Disease; Nervous System Diseases; Neurodegenerative Diseases; Neurotoxins; Parkinsonian Disorders; Permeability

2007

Trials

1 trial(s) available for manganese and Huntington Disease

ArticleYear
Modification of Parkinsonism--chronic treatment with L-dopa.
    The New England journal of medicine, 1969, Feb-13, Volume: 280, Issue:7

    Topics: Adult; Aged; Agranulocytosis; Aromatic Amino Acid Decarboxylase Inhibitors; Blood Urea Nitrogen; Blood-Brain Barrier; Chronic Disease; Dihydroxyphenylalanine; Dopamine; Feeding and Eating Disorders; Female; Humans; Huntington Disease; Male; Manganese; Mental Processes; Methyldopa; Middle Aged; Movement Disorders; Nausea; Neurologic Manifestations; Parkinson Disease; Phenylacetates; Placebos; Thyroid Function Tests; Tyrosine; Vomiting

1969

Other Studies

21 other study(ies) available for manganese and Huntington Disease

ArticleYear
YAC128 mouse model of Huntington disease is protected against subtle chronic manganese (Mn)-induced behavioral and neuropathological changes.
    Neurotoxicology, 2021, Volume: 87

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hand Strength; Huntington Disease; Male; Manganese; Maze Learning; Mice; Mice, Transgenic; Neuroprotective Agents; Open Field Test; Rotarod Performance Test

2021
Manganese-induced hyperactivity and dopaminergic dysfunction depend on age, sex and YAC128 genotype.
    Pharmacology, biochemistry, and behavior, 2022, Volume: 213

    Topics: Age Factors; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Female; Genotype; Huntington Disease; Hyperkinesis; Manganese; Mice; Motor Activity; Nucleus Accumbens; Serotonin; Sex Factors; Tyrosine 3-Monooxygenase

2022
Alterations in metal homeostasis occur prior to canonical markers in Huntington disease.
    Scientific reports, 2022, 06-20, Volume: 12, Issue:1

    Topics: Biomarkers; Copper; Homeostasis; Humans; Huntington Disease; Iron; Manganese; Metals; Zinc

2022
Mn(II) Quinoline Complex (4QMn) Restores Proteostasis and Reduces Toxicity in Experimental Models of Huntington's Disease.
    International journal of molecular sciences, 2022, Aug-11, Volume: 23, Issue:16

    Topics: Animals; Disease Models, Animal; Humans; Huntingtin Protein; Huntington Disease; Manganese; Models, Theoretical; Proteasome Endopeptidase Complex; Proteostasis; Quinolines

2022
Impaired XK recycling for importing manganese underlies striatal vulnerability in Huntington's disease.
    The Journal of cell biology, 2022, 10-03, Volume: 221, Issue:10

    Topics: Amino Acid Transport Systems, Neutral; Animals; Corpus Striatum; Endosomes; Huntington Disease; Manganese; Mice; Neurons; Proteome; rab GTP-Binding Proteins

2022
Endosomal recycling defects link Huntington's disease with McLeod syndrome.
    The Journal of cell biology, 2022, 10-03, Volume: 221, Issue:10

    Topics: Amino Acid Transport Systems, Neutral; Cell Membrane; Endosomes; Humans; Huntington Disease; Manganese; Neuroacanthocytosis; rab GTP-Binding Proteins

2022
Widespread selenium deficiency in the brain of cases with Huntington's disease presents a new potential therapeutic target.
    EBioMedicine, 2023, Volume: 97

    Topics: Brain; Calcium; Copper; Humans; Huntington Disease; Iron; Manganese; Neurodegenerative Diseases; Potassium; Selenium; Sodium; Zinc

2023
Huntington's disease associated resistance to Mn neurotoxicity is neurodevelopmental stage and neuronal lineage dependent.
    Neurotoxicology, 2019, Volume: 75

    Topics: Brain; Case-Control Studies; Cell Differentiation; Cell Lineage; Corpus Striatum; Dose-Response Relationship, Drug; Female; Humans; Huntington Disease; Induced Pluripotent Stem Cells; Male; Manganese; Mesencephalon; Neurons

2019
Acute manganese treatment restores defective autophagic cargo loading in Huntington's disease cell lines.
    Human molecular genetics, 2019, 11-15, Volume: 28, Issue:22

    Topics: Animals; Autophagosomes; Autophagy; Cell Line; Disease Models, Animal; HEK293 Cells; Humans; Huntingtin Protein; Huntington Disease; Induced Pluripotent Stem Cells; Manganese; Mice; Microscopy, Electron; Mutation; Neurons

2019
Huntington's disease genotype suppresses global manganese-responsive processes in pre-manifest and manifest YAC128 mice.
    Metallomics : integrated biometal science, 2020, 07-22, Volume: 12, Issue:7

    Topics: Animals; Disease Models, Animal; Genotype; Huntington Disease; Manganese; Mice

2020
Manganese-induced Mitochondrial Dysfunction Is Not Detectable at Exposures Below the Acute Cytotoxic Threshold in Neuronal Cell Types.
    Toxicological sciences : an official journal of the Society of Toxicology, 2020, 08-01, Volume: 176, Issue:2

    Topics: Cell Line; Corpus Striatum; Humans; Huntington Disease; Manganese; Mitochondria; Neurons

2020
Striatal Cholesterol Precursors Are Altered with Age in Female Huntington's Disease Model Mice.
    Journal of Huntington's disease, 2019, Volume: 8, Issue:2

    Topics: Aging; Animals; Cholesterol; Corpus Striatum; Disease Models, Animal; Female; Huntington Disease; Male; Manganese; Mice; Mice, Transgenic

2019
A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease.
    Human molecular genetics, 2015, Apr-01, Volume: 24, Issue:7

    Topics: Amino Acid Motifs; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Line; Corpus Striatum; Disease Models, Animal; DNA Damage; Female; Humans; Huntington Disease; Male; Manganese; Mice; Neural Stem Cells; Phosphorylation; Signal Transduction; Tumor Suppressor Protein p53

2015
Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese status.
    Metallomics : integrated biometal science, 2015, Volume: 7, Issue:2

    Topics: Animals; Cell Line; Huntington Disease; Manganese; Metabolomics; Mice; Models, Biological; Neurons; Principal Component Analysis

2015
Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model.
    Biochimica et biophysica acta. Molecular basis of disease, 2017, Volume: 1863, Issue:6

    Topics: Animals; Arginase; Corpus Striatum; Disease Models, Animal; Huntington Disease; Male; Manganese; Mice; Neurons; Urea

2017
Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure.
    Journal of neurochemistry, 2010, Volume: 112, Issue:1

    Topics: Animals; Cattle; Cell Line; Cell Survival; Drug Evaluation, Preclinical; Humans; Huntingtin Protein; Huntington Disease; Manganese; Mice; Mice, Transgenic; Nerve Tissue Proteins; Nuclear Proteins

2010
Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 117, Issue:1

    Topics: Animals; Biological Transport; Cation Transport Proteins; Corpus Striatum; Disease Models, Animal; Homeostasis; Humans; Huntingtin Protein; Huntington Disease; Iron; Manganese; Mice; Nerve Tissue Proteins; Nuclear Proteins

2010
Novel high-throughput assay to assess cellular manganese levels in a striatal cell line model of Huntington's disease confirms a deficit in manganese accumulation.
    Neurotoxicology, 2011, Volume: 32, Issue:5

    Topics: Animals; Cell Line; Corpus Striatum; Fura-2; High-Throughput Screening Assays; Huntington Disease; Manganese; Mice; Mice, Mutant Strains; Mutation

2011
Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolism.
    PloS one, 2012, Volume: 7, Issue:2

    Topics: Animals; Dendrites; Dopamine; Environmental Exposure; Genotype; Huntington Disease; Male; Manganese; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multivariate Analysis; Neostriatum; Neurons

2012
[Microelement metabolism in patients with hereditary extrapyramidal diseases].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1978, Volume: 78, Issue:2

    Topics: Adolescent; Adult; Brain Diseases; Child; Dystonia Musculorum Deformans; Humans; Huntington Disease; Iron; Manganese; Middle Aged; Pantothenate Kinase-Associated Neurodegeneration; Trace Elements; Zinc

1978
Penicillamine in Huntington's chorea.
    Postgraduate medical journal, 1974, Volume: 50 Suppl 2

    Topics: Humans; Huntington Disease; Manganese; Penicillamine

1974