manganese(iii)tetraphenylporphine-sulfonate has been researched along with Neurilemmoma* in 2 studies
2 other study(ies) available for manganese(iii)tetraphenylporphine-sulfonate and Neurilemmoma
| Article | Year |
|---|---|
Quantitative magnetic resonance imaging of rat brain tumors: in vivo NMR relaxometry for the discrimination of normal and pathological tissues.
The in vivo relaxation times T1 and T2 were quantitatively determined in rat brain. Animals with implanted experimental brain tumors were investigated for discrimination of pathological regions from normal brain structures based on relaxation time differences. The different cerebral tumors (glioma, schwannoma, neuroblastoma) showed no difference in relaxation times, but all tumors had T1(1301 +/- 167 ms) and T2(91 +/- 9 ms) times distinctly longer than normal brain (T1: 1057 +/- 77 ms; T2: 77 +/- 6 ms). T1 can be used for distinction of tumor and edema from normal brain, while T2 is the better parameter for discrimination between tumor and edema. Furthermore, the effect of MRI contrast agents (GdDTPA, MnTPPS, GdTPPS) on the relaxation times of these experimental brain tumors was measured. The enhancement of tumors produced by GdDTPA disappeared within ten minutes after i.p. application. At later times, central cysts and peritumoral edema became the most enhanced structures. The enhancement of tumor following MnTPPS application remained unchanged in T1-weighted images during the whole observation period of four days. A significant reduction of enhancement was not observed during this time. The effect of MnTPPS on T2 was weak. Replacement of manganese with gadolinium as the central ion of the porphyrin TPPS led to a contrast agent with enhancement effects on both, T1- and T2-weighted images. Topics: Analysis of Variance; Animals; Brain Edema; Brain Neoplasms; Contrast Media; Diagnosis, Differential; Gadolinium; Gadolinium DTPA; Glioma; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Manganese; Metalloporphyrins; Neurilemmoma; Neuroblastoma; Organometallic Compounds; Pentetic Acid; Rats; Rats, Inbred F344; Tumor Cells, Cultured | 1994 |
Identification of intracranial liqor metastases of experimental stereotactically implanted brain tumors by the tumor-selective MRI contrast agent MnTPPS.
Two cases of stereotactically induced and spontaneously metastasizing neoplasms in the rat and the cat brain are reported. In the rat, a malignant Schwannoma derived from initially supratentorially implanted RN6 cells developed a second tumor in the posterior cranial fossa. In the cat, a highly malignant polymorphous anaplastic glioma induced by implantation of cloned rat glioma cells (F98) into the left internal capsule developed small tumor cell nests along the ependyma of the ipsilateral ventricle. In precontrast magnetic resonance imaging (MRI) of both cases, the primary tumor was detectable only by a very weak hypointensity and through a shift of the midline. No metastases were apparent. Application of the metallated paramagnetic porphyrin derivative manganese(III) tetraphenylporphine sulfonate (MnTPPS) resulted in a remarkable contrast enhancement between tumoral and normal tissue, which was evident not only in the primary tumor but also in the small metastases. These observations demonstrate for the first time that MnTPPS is an efficient MRI contrast agent for the detection of metastases from primary brain neoplasms and, in consequence, support the hypothesis of its selective binding to tumor cells. Topics: Animals; Brain Neoplasms; Cats; Contrast Media; Female; Glioma; Magnetic Resonance Imaging; Male; Manganese; Metalloporphyrins; Neoplasm Metastasis; Neoplasm Transplantation; Neurilemmoma; Rats; Rats, Inbred F344; Stereotaxic Techniques | 1992 |