maneb has been researched along with Colonic-Neoplasms* in 2 studies
2 other study(ies) available for maneb and Colonic-Neoplasms
| Article | Year |
|---|---|
Inhibitors for the mutagenicities of colon carcinogens, 1,2-dimethylhydrazine and azoxymethane, in the host-mediated assay.
Inhibitory effects of several chemicals on the mutagenicities of 1,2-dimethylhydrazine (DMH) and azoxymethane (AOM) for Salmonella typhimurium G46 in the host-mediated assay were investigated. They were carbon disulfide (CS2), tetraethylthiuram disulfide (disulfiram, DSF), sodium diethyldithiocarbamate (SDDC), ethylene-bis(dithiocarbamato) manganese (Maneb), pyrazole (PZ), aminoacetonitrile hydrogen sulfate (AAN), and sodium selenite (SE). All the compounds, except for SE, inhibited the mutagenicities of DMH and AOM. Topics: Aminoacetonitrile; Animals; Azo Compounds; Azoxymethane; Carbon Disulfide; Colonic Neoplasms; Dimethylhydrazines; Disulfiram; Ditiocarb; Drug Evaluation, Preclinical; Male; Maneb; Methylhydrazines; Mice; Mutagens; Neoplasms, Experimental; Pyrazoles | 1979 |
Inhibits of of colon carcinogenesis.
Disulfiram (tetraethylthiuram disulfide, Antabuse) and sodium diethyldithiocarbamate, when added to the diet, inhibit 1,2-dimethylhydrazine (DMH)-induced neoplasia of the large bowel in female CF1 mice. Ethylene bis(dithiocarbamato)manganese (Maneb) and bis(ethylxanthogen), two pesticides with structural similarities to disulfiram, produce comparable inhibition of DHM. In other work, disulfiram was found to inhibit the carcinogenic effect of azoxymethane (AOM) on the large bowel. Under comparable conditions the inhibition of AOM was considerably less than that obtained with DMH as the carcinogen. The data suggest that disulfiram inhibits DMH metabolism at more than one oxidative step. Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Disulfides; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Female; Maneb; Mice; Thiocarbamates | 1977 |