manassantin-b has been researched along with Inflammation* in 1 studies
1 other study(ies) available for manassantin-b and Inflammation
| Article | Year |
|---|---|
Manassantin A and B from Saururus chinensis inhibit interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells.
Inhibition of interleukin-6 (IL-6) has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine potential effects of manassantin A and B isolated from Saururus chinensis on the IL-6-induced response to human hepatoma cells. We found that manassantin A and B inhibit signal transducer and activator of transcription 3 (Stat3) activity stimulated by IL-6. We also found that both compounds decreased IL-6-induced Stat3 phosphorylation and nuclear translocation. Both compounds blocked suppressor of cytokine signaling 3 (SOCS-3)-mRNA expression induced by IL-6. In addition, we found that Stat3 inhibitory effects of these compounds could be related to protein tyrosine phosphatase. These findings suggest that manassantin A and B could be useful remedies for treatment of inflammatory diseases by inhibiting IL-6 action. Topics: Active Transport, Cell Nucleus; Carcinoma, Hepatocellular; Furans; Humans; Inflammation; Interleukin-6; Lignans; Phosphorylation; Protein Tyrosine Phosphatases; Saururaceae; Signal Transduction; STAT3 Transcription Factor; Tumor Cells, Cultured | 2011 |