manassantin-a has been researched along with Inflammation* in 2 studies
2 other study(ies) available for manassantin-a and Inflammation
| Article | Year |
|---|---|
Manassantin A and B from Saururus chinensis inhibit interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells.
Inhibition of interleukin-6 (IL-6) has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine potential effects of manassantin A and B isolated from Saururus chinensis on the IL-6-induced response to human hepatoma cells. We found that manassantin A and B inhibit signal transducer and activator of transcription 3 (Stat3) activity stimulated by IL-6. We also found that both compounds decreased IL-6-induced Stat3 phosphorylation and nuclear translocation. Both compounds blocked suppressor of cytokine signaling 3 (SOCS-3)-mRNA expression induced by IL-6. In addition, we found that Stat3 inhibitory effects of these compounds could be related to protein tyrosine phosphatase. These findings suggest that manassantin A and B could be useful remedies for treatment of inflammatory diseases by inhibiting IL-6 action. Topics: Active Transport, Cell Nucleus; Carcinoma, Hepatocellular; Furans; Humans; Inflammation; Interleukin-6; Lignans; Phosphorylation; Protein Tyrosine Phosphatases; Saururaceae; Signal Transduction; STAT3 Transcription Factor; Tumor Cells, Cultured | 2011 |
Manassantin A isolated from Saururus chinensis inhibits 5-lipoxygenase-dependent leukotriene C4 generation by blocking mitogen-activated protein kinase activation in mast cells.
In this study, manassantin A (Man A), an herbal medicine isolated from Saururus chinensis (S. chinensis), markedly inhibited 5-lipoxygenase (5-LO)-dependent leukotriene C(4) (LTC(4)) generation in bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner. To investigate the molecular mechanisms underlying the inhibition of LTC(4) generation by Man A, we assessed the effects of Man A on phosphorylation of cytosolic phospholipase A(2) (cPLA(2)) and mitogen-activated protein kinases (MAPKs). Inhibition of LTC(4) generation by Man A was accompanied by a decrease in cPLA(2) phosphorylation, which occurred via the MAPKs including extracellular signal-regulated protein kinase-1/2 (ERK1/2) as well as p38 and c-Jun N-terminal kinase (JNK) pathways. Taken together, the present study suggests the Man A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases. Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Bone Marrow; Dose-Response Relationship, Drug; Enzyme Activation; Inflammation; Leukotriene C4; Lignans; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phospholipases A2; Phosphorylation; Phytotherapy; Plant Extracts; Saururaceae | 2011 |