maltodextrin and Liver-Failure--Acute

There has been increasing interest in the development of pathological stimulus-activatable nanoplatforms with theranostic functions. Here, we report ketalized maltodextrin (KMD) nanoparticles which are able to deliver therapeutic and imaging functions to the acidic conditions simultaneously, as may be found in the site of inflammation. KMD was synthesized as a platform of the theranostic nanoparticles by conjugating acid-cleavable hydrophobic moieties to maltodextrin through carbonate bonds. KMD nanoparticles could undergo acid-triggered hydrolytic degradation to generate carbon dioxide (CO

Topics: 3T3 Cells; Animals; Antioxidants; Cytokines; Drug Carriers; Drug Liberation; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Liver; Liver Failure, Acute; Mice; Mice, Nude; Nanoparticles; Polysaccharides; RAW 264.7 Cells; Reactive Oxygen Species; Silymarin; Tissue Distribution; Ultrasonography