malonic acid has been researched along with Nerve Degeneration in 11 studies
malonic acid : An alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.
dicarboxylic acid : Any carboxylic acid containing two carboxy groups.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "24 h after injection, rigidity and catalepsy were measured, as well as, at the end of the three week period, locomotion, rearing and exploratory behavior." | 1.31 | Local application of L- threo-hydroxyaspartate and malonate in rats in vivo induces rigidity and damages neurons of the substantia nigra, pars compacta. ( Loopuijt, LD, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Valdeolivas, S | 1 |
| Pazos, MR | 2 |
| Bisogno, T | 1 |
| Piscitelli, F | 1 |
| Iannotti, FA | 1 |
| Allarà, M | 1 |
| Sagredo, O | 1 |
| Di Marzo, V | 1 |
| Fernández-Ruiz, J | 2 |
| Gómez-Cañas, M | 1 |
| Morales, P | 1 |
| García-Toscano, L | 1 |
| Navarrete, C | 1 |
| Muñoz, E | 1 |
| Jagerovic, N | 1 |
| García-Arencibia, M | 1 |
| Brunet, N | 1 |
| Tarabal, O | 1 |
| Esquerda, JE | 1 |
| Calderó, J | 1 |
| Loopuijt, LD | 1 |
| Lorenc-Koci, E | 1 |
| Gołembiowska, K | 1 |
| Wardas, J | 1 |
| Fernandez-Gomez, FJ | 1 |
| Gomez-Lazaro, M | 1 |
| Pastor, D | 1 |
| Calvo, S | 1 |
| Aguirre, N | 1 |
| Galindo, MF | 1 |
| Jordán, J | 1 |
| Bazzett, TJ | 1 |
| Falik, RC | 1 |
| Becker, JB | 1 |
| Albin, RL | 1 |
| Connop, BP | 2 |
| Boegman, RJ | 2 |
| Beninger, RJ | 2 |
| Jhamandas, K | 2 |
| Maragos, WF | 1 |
| Jakel, RJ | 1 |
| Pang, Z | 1 |
| Geddes, JW | 1 |
| Moy, LY | 1 |
| Zeevalk, GD | 1 |
| Sonsalla, PK | 1 |
11 other studies available for malonic acid and Nerve Degeneration
| Article | Year |
|---|---|
The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG.
Topics: Animals; Arachidonic Acids; Brain-Derived Neurotrophic Factor; Cell Death; Cyclooxygenase 2; Cytopro | 2013 |
Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile.
Topics: Animals; Binding Sites; Blood-Brain Barrier; Brain; Brain Injuries; Cannabinoid Receptor Agonists; C | 2016 |
Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.
Topics: Animals; Calcium Signaling; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; | 2009 |
Local application of L- threo-hydroxyaspartate and malonate in rats in vivo induces rigidity and damages neurons of the substantia nigra, pars compacta.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain Mapping; Catalepsy; Cell Count; Coloring Agents; Loc | 2002 |
1,2,3,4-Tetrahydroisoquinoline protects terminals of dopaminergic neurons in the striatum against the malonate-induced neurotoxicity.
Topics: Analysis of Variance; Animals; Dopamine; Energy Metabolism; Male; Malonates; Medial Forebrain Bundle | 2005 |
Minocycline fails to protect cerebellar granular cell cultures against malonate-induced cell death.
Topics: Animals; Animals, Newborn; Apoptosis; Cardiolipins; Caspases; Cells, Cultured; Cerebellar Cortex; Do | 2005 |
Chronic administration of malonic acid produces selective neural degeneration and transient changes in calbindin immunoreactivity in rat striatum.
Topics: Animals; Calbindins; Cell Count; Corpus Striatum; Dose-Response Relationship, Drug; Immunohistochemi | 1995 |
Attenuation of malonate-induced degeneration of the nigrostriatal pathway by inhibitors of nitric oxide synthase.
Topics: Analysis of Variance; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Enzyme Inhibitors; | 1996 |
Malonate-induced degeneration of basal forebrain cholinergic neurons: attenuation by lamotrigine, MK-801, and 7-nitroindazole.
Topics: Animals; Dizocilpine Maleate; Enzyme Inhibitors; Indazoles; Lamotrigine; Male; Malonates; Nerve Dege | 1997 |
6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions.
Topics: Animals; Antihypertensive Agents; Corpus Striatum; Denervation; Male; Malonates; Mitochondria; Nerve | 1998 |
Role for dopamine in malonate-induced damage in vivo in striatum and in vitro in mesencephalic cultures.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; 3,4-Dihydrox | 2000 |