malonic acid has been researched along with Disease Models, Animal in 33 studies
malonic acid : An alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.
dicarboxylic acid : Any carboxylic acid containing two carboxy groups.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated the in vitro antioxidant activity of (E)-2-benzylidene-4-phenyl-1,3-diselenole (BPD), the anticonvulsant effect of BPD on seizures induced by pilocarpine (PC), pentylenetetrazole (PTZ) and 4-aminopyridine (4-AMP) and the mechanism involved." | 3.76 | Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Roman, SS; Wilhelm, EA, 2010) |
| "Malonic acid (MA) is a reversible inhibitor of succinate dehydrogenase (SDH) which induces mitochondrial dysfunction followed by secondary excitotoxicity and apoptosis due to generation of reactive oxygen species." | 1.39 | Synergistical neuroprotection of rofecoxib and statins against malonic acid induced Huntington's disease like symptoms and related cognitive dysfunction in rats. ( Kalonia, H; Kumar, A; Mishra, J; Sharma, N, 2013) |
| "Cystamine treatment of various genetic models of HD demonstrated protection against neurodegeneration and/or improvement in behavior." | 1.37 | Cystamine and ethyl-eicosapentaenoic acid treatment fail to prevent malonate-induced striatal toxicity in mice. ( Leavitt, BR; Sivananthan, SN, 2011) |
| "Quinolinic acid has been reported to induce excitotoxicity by stimulating the N-methyl-D-aspartate receptor, causing calcium overload which in turn leads to the neurodegeneration." | 1.36 | Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats. ( Kalonia, H; Kumar, A; Kumar, P; Nehru, B, 2010) |
| "Transgenic Huntington's disease (HD) mice, expressing exon 1 of the HD gene with an expanded CAG repeat, are totally resistant to striatal lesion induced by excessive NMDA receptor activation." | 1.31 | Partial resistance to malonate-induced striatal cell death in transgenic mouse models of Huntington's disease is dependent on age and CAG repeat length. ( Bates, GP; Brundin, P; Castilho, RF; Hansson, O; Korhonen, L; Lindholm, D, 2001) |
| "The gene defect in Huntington's disease (HD) may result in an impairment of energy metabolism." | 1.30 | Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. ( Beal, MF; Ferrante, RJ; Jenkins, BG; Kaddurah-Daouk, R; Matthews, RT; Rosen, BR; Yang, L, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.03) | 18.2507 |
| 2000's | 19 (57.58) | 29.6817 |
| 2010's | 9 (27.27) | 24.3611 |
| 2020's | 4 (12.12) | 2.80 |
| Authors | Studies |
|---|---|
| Oki, S | 1 |
| Kageyama, S | 1 |
| Morioka, Y | 1 |
| Namba, T | 1 |
| Le Friec, A | 1 |
| Desmoulin, F | 1 |
| Demain, B | 1 |
| Davoust, C | 1 |
| Robert, L | 1 |
| Duval, T | 1 |
| Rémy, F | 1 |
| Cirillo, C | 1 |
| Loubinoux, I | 1 |
| Prag, HA | 1 |
| Pala, L | 1 |
| Kula-Alwar, D | 1 |
| Mulvey, JF | 1 |
| Luping, D | 1 |
| Beach, TE | 1 |
| Booty, LM | 1 |
| Hall, AR | 1 |
| Logan, A | 1 |
| Sauchanka, V | 1 |
| Caldwell, ST | 1 |
| Robb, EL | 1 |
| James, AM | 1 |
| Xu, Z | 1 |
| Saeb-Parsy, K | 1 |
| Hartley, RC | 1 |
| Murphy, MP | 1 |
| Krieg, T | 1 |
| Chandler, RJ | 1 |
| Venturoni, LE | 1 |
| Liao, J | 1 |
| Hubbard, BT | 1 |
| Schneller, JL | 1 |
| Hoffmann, V | 1 |
| Gordo, S | 1 |
| Zang, S | 1 |
| Ko, CW | 1 |
| Chau, N | 1 |
| Chiang, K | 1 |
| Kay, MA | 1 |
| Barzel, A | 1 |
| Venditti, CP | 1 |
| Kumar, A | 3 |
| Sharma, N | 1 |
| Mishra, J | 1 |
| Kalonia, H | 3 |
| Wang, Y | 1 |
| Wang, YG | 1 |
| Ma, TF | 1 |
| Li, M | 1 |
| Gu, SL | 1 |
| Gómez-Cañas, M | 1 |
| Morales, P | 1 |
| García-Toscano, L | 1 |
| Navarrete, C | 1 |
| Muñoz, E | 1 |
| Jagerovic, N | 1 |
| Fernández-Ruiz, J | 5 |
| García-Arencibia, M | 1 |
| Pazos, MR | 2 |
| Zubiría, MG | 1 |
| Alzamendi, A | 1 |
| Moreno, G | 1 |
| Portales, A | 1 |
| Castrogiovanni, D | 1 |
| Spinedi, E | 1 |
| Giovambattista, A | 1 |
| Prigol, M | 1 |
| Wilhelm, EA | 2 |
| Schneider, CC | 1 |
| Nogueira, CW | 2 |
| Sagredo, O | 2 |
| González, S | 1 |
| Aroyo, I | 1 |
| Benito, C | 1 |
| Lastres-Becker, I | 2 |
| Romero, JP | 1 |
| Tolón, RM | 1 |
| Mechoulam, R | 1 |
| Brouillet, E | 2 |
| Romero, J | 1 |
| Brunet, N | 1 |
| Tarabal, O | 1 |
| Esquerda, JE | 1 |
| Calderó, J | 1 |
| Kumar, P | 2 |
| Nehru, B | 1 |
| Jesse, CR | 1 |
| Roman, SS | 1 |
| Bortolatto, CF | 1 |
| Sivananthan, SN | 1 |
| Leavitt, BR | 1 |
| Valdeolivas, S | 1 |
| Satta, V | 1 |
| Pertwee, RG | 1 |
| Petersén, A | 1 |
| Puschban, Z | 1 |
| Lotharius, J | 1 |
| NicNiocaill, B | 1 |
| Wiekop, P | 1 |
| O'Connor, WT | 1 |
| Brundin, P | 2 |
| Bizat, N | 1 |
| Boyer, F | 1 |
| Hantraye, P | 1 |
| Fancellu, R | 1 |
| Armentero, MT | 1 |
| Nappi, G | 1 |
| Blandini, F | 1 |
| Murphy, RC | 1 |
| Messer, A | 1 |
| Klivenyi, P | 4 |
| Starkov, AA | 1 |
| Calingasan, NY | 1 |
| Gardian, G | 1 |
| Browne, SE | 1 |
| Yang, L | 2 |
| Bubber, P | 1 |
| Gibson, GE | 1 |
| Patel, MS | 1 |
| Beal, MF | 5 |
| Kanki, R | 1 |
| Nakamizo, T | 1 |
| Yamashita, H | 1 |
| Kihara, T | 1 |
| Sawada, H | 1 |
| Uemura, K | 1 |
| Kawamata, J | 1 |
| Shibasaki, H | 1 |
| Akaike, A | 1 |
| Shimohama, S | 1 |
| Cornet, S | 1 |
| Spinnewyn, B | 1 |
| Delaflotte, S | 1 |
| Charnet, C | 1 |
| Roubert, V | 1 |
| Favre, C | 1 |
| Hider, H | 1 |
| Chabrier, PE | 1 |
| Auguet, M | 1 |
| Diao, ZY | 1 |
| Shen, Y | 1 |
| Fan, DS | 1 |
| Zheng, M | 1 |
| Cui, JY | 1 |
| Sun, AP | 1 |
| Song, DM | 1 |
| Fan, SG | 1 |
| de Lago, E | 1 |
| Ortega-Gutiérrez, S | 1 |
| Cabranes, A | 1 |
| Pryce, G | 1 |
| Baker, D | 1 |
| López-Rodríguez, M | 1 |
| Ramos, JA | 1 |
| Li, J | 1 |
| Calkins, MJ | 1 |
| Johnson, DA | 1 |
| Johnson, JA | 1 |
| Matthews, RT | 1 |
| Jenkins, BG | 1 |
| Ferrante, RJ | 4 |
| Rosen, BR | 1 |
| Kaddurah-Daouk, R | 1 |
| Andreassen, OA | 3 |
| Dedeoglu, A | 3 |
| Mueller, G | 1 |
| Lancelot, E | 1 |
| Bogdanov, M | 1 |
| Andersen, JK | 1 |
| Jiang, D | 1 |
| Kaal, EC | 1 |
| Vlug, AS | 1 |
| Versleijen, MW | 1 |
| Kuilman, M | 1 |
| Joosten, EA | 1 |
| Bär, PR | 1 |
| Hughes, DB | 1 |
| Ona, VO | 1 |
| Friedlander, RM | 1 |
| Albers, DW | 1 |
| Carlson, EJ | 1 |
| Epstein, CJ | 1 |
| Demougeot, C | 1 |
| Garnier, P | 1 |
| Mossiat, C | 1 |
| Bertrand, N | 1 |
| Giroud, M | 1 |
| Beley, A | 1 |
| Marie, C | 1 |
| Hansson, O | 1 |
| Castilho, RF | 1 |
| Korhonen, L | 1 |
| Lindholm, D | 1 |
| Bates, GP | 1 |
1 review available for malonic acid and Disease Models, Animal
| Article | Year |
|---|---|
Role of Nrf2-dependent ARE-driven antioxidant pathway in neuroprotection.
Topics: Animals; Antioxidants; Cell Death; Corpus Striatum; Disease Models, Animal; Electron Transport Compl | 2007 |
32 other studies available for malonic acid and Disease Models, Animal
| Article | Year |
|---|---|
Malonate induces the browning of white adipose tissue in high-fat diet induced obesity model.
Topics: Adipocytes, White; Adipose Tissue, White; Animals; Diet, High-Fat; Disease Models, Animal; Malonates | 2023 |
A Reproducible New Model of Focal Ischemic Injury in the Marmoset Monkey: MRI and Behavioural Follow-Up.
Topics: Animals; Callithrix; Disease Models, Animal; Female; Follow-Up Studies; Hand Strength; Ischemic Stro | 2021 |
Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.
Topics: Animals; Cardiotonic Agents; Cell Line; Disease Models, Animal; Esters; Female; Humans; Male; Malona | 2022 |
Promoterless, Nuclease-Free Genome Editing Confers a Growth Advantage for Corrected Hepatocytes in Mice With Methylmalonic Acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Animals, Newborn; Biomarkers; Carcinoma, Hepatocellul | 2021 |
Synergistical neuroprotection of rofecoxib and statins against malonic acid induced Huntington's disease like symptoms and related cognitive dysfunction in rats.
Topics: Animals; Atorvastatin; Behavior, Animal; Brain; Cognition Disorders; Cyclooxygenase 2 Inhibitors; Cy | 2013 |
Dynamic metabolites profile of cerebral ischemia/reperfusion revealed by (1)H NMR-based metabolomics contributes to potential biomarkers.
Topics: Animals; Biomarkers; Brain Ischemia; Disease Models, Animal; Glycine; Magnetic Resonance Spectroscop | 2014 |
Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile.
Topics: Animals; Binding Sites; Blood-Brain Barrier; Brain; Brain Injuries; Cannabinoid Receptor Agonists; C | 2016 |
Relationship between the Balance of Hypertrophic/Hyperplastic Adipose Tissue Expansion and the Metabolic Profile in a High Glucocorticoids Model.
Topics: Adipocytes; Adipogenesis; Adiposity; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultu | 2016 |
Protective effect of unsymmetrical dichalcogenide, a novel antioxidant agent, in vitro and an in vivo model of brain oxidative damage.
Topics: Administration, Oral; Animals; Antioxidants; Brain; Disease Models, Animal; Dose-Response Relationsh | 2008 |
Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease.
Topics: Animals; Arachidonic Acids; Camphanes; Cannabinoids; Cell Death; Central Nervous System Agents; Corp | 2009 |
Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.
Topics: Animals; Calcium Signaling; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; | 2009 |
Targeting oxidative stress attenuates malonic acid induced Huntington like behavioral and mitochondrial alterations in rats.
Topics: Animals; Body Weight; Disease Models, Animal; Drug Delivery Systems; Huntington Disease; Lipid Perox | 2010 |
Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats.
Topics: Acetates; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Cata | 2010 |
Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, Animal; Dose-Respons | 2010 |
Cystamine and ethyl-eicosapentaenoic acid treatment fail to prevent malonate-induced striatal toxicity in mice.
Topics: Animals; Corpus Striatum; Cystamine; Disease Models, Animal; Eicosapentaenoic Acid; Huntington Disea | 2011 |
Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors.
Topics: Animals; Cannabidiol; Cannabinoids; Disease Models, Animal; Dronabinol; Drug Combinations; Drug Ther | 2012 |
Evidence for dysfunction of the nigrostriatal pathway in the R6/1 line of transgenic Huntington's disease mice.
Topics: Animals; Cell Count; Corpus Striatum; Disease Models, Animal; Dopamine; Female; Fluorescent Dyes; Hu | 2002 |
Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Corpus Striatum; Disease Models, Animal; Dro | 2003 |
Neuroprotective effects mediated by dopamine receptor agonists against malonate-induced lesion in the rat striatum.
Topics: Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dose-Resp | 2003 |
A single-chain Fv intrabody provides functional protection against the effects of mutant protein in an organotypic slice culture model of Huntington's disease.
Topics: Animals; Animals, Newborn; Biolistics; Cell Aggregation; Cell Count; Cell Death; Corpus Striatum; Cu | 2004 |
Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Caudate Nucleus; Cell Count; Cerebral Cortex; | 2004 |
Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons.
Topics: Animals; Antimycin A; Calcium Channel Blockers; Calcium Channels; Cell Death; Disease Models, Animal | 2004 |
Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline.
Topics: Animals; Binding, Competitive; Brain Ischemia; Carrageenan; Corpus Striatum; Disease Models, Animal; | 2004 |
[Establishment of the organotypic model of amyotrophic lateral sclerosis from the SD rats' spinal cord].
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Cells, Cultured; Disease Models, Animal; M | 2005 |
UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Arachidonic Acids; Brain Chemistry; D | 2006 |
Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Antineoplastic Agents; Creatine; Creatinin | 1998 |
Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemist | 2000 |
Chronic mitochondrial inhibition induces selective motoneuron death in vitro: a new model for amyotrophic lateral sclerosis.
Topics: Adenosine Triphosphate; Amyotrophic Lateral Sclerosis; Animals; Cell Survival; Cells, Cultured; Dise | 2000 |
Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant.
Topics: Animals; Brain; Caspase 1; Crosses, Genetic; Disease Models, Animal; Female; Huntington Disease; Mal | 2000 |
Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Carrier Prote | 2001 |
N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury.
Topics: 2,2'-Dipyridyl; Acute Disease; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Brain Edema; Bra | 2001 |
Partial resistance to malonate-induced striatal cell death in transgenic mouse models of Huntington's disease is dependent on age and CAG repeat length.
Topics: Aging; Amino Acid Chloromethyl Ketones; Animals; bcl-X Protein; Blood Glucose; Cell Death; Corpus St | 2001 |