malic acid has been researched along with Sjogren's Syndrome in 2 studies
malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.
2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The malic acid treatment resulted in a greater effect size and percentage improvement than citric acid mouthwash." | 2.94 | Patient-related outcomes in Sjögren syndrome treated with stimulants of salivary secretion: Randomized clinical trial. ( Amaral, JPAR; Barcelos, F; da Mata, ADSP; Marques, DNDS; Pereira, RMN; Thomson, WM; Vaz Patto, J, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| da Mata, ADSP | 1 |
| Amaral, JPAR | 1 |
| Thomson, WM | 1 |
| Barcelos, F | 1 |
| Vaz Patto, J | 1 |
| Pereira, RMN | 1 |
| Marques, DNDS | 1 |
| da Silva Marques, DN | 1 |
| da Mata, AD | 1 |
| Patto, JM | 1 |
| Barcelos, FA | 1 |
| de Almeida Rato Amaral, JP | 1 |
| de Oliveira, MC | 1 |
| Ferreira, CG | 1 |
2 trials available for malic acid and Sjogren's Syndrome
| Article | Year |
|---|---|
Patient-related outcomes in Sjögren syndrome treated with stimulants of salivary secretion: Randomized clinical trial.
Topics: Citric Acid; Female; Humans; Malates; Male; Middle Aged; Mouthwashes; Quality of Life; Saliva; Saliv | 2020 |
Effects of gustatory stimulants of salivary secretion on salivary pH and flow in patients with Sjögren's syndrome: a randomized controlled trial.
Topics: Adult; Buffers; Citric Acid; Double-Blind Method; Female; Fluorides; Follow-Up Studies; Humans; Hydr | 2011 |