malic acid has been researched along with Myocardial Ischemia in 7 studies
malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.
2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "A mixture of mitochondrial substrates of succinic and malic acids more effectively than antihypoxant trimetazidine prevented functional and metabolic disorders in rat myocardium during acute ischemia: reduces T wave amplitude, QT interval, number and duration of arrhythmias, and restores oxidation-phosphorylation coupling." | 7.74 | Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia. ( Chernyschova, GA; Khazanov, VA; Kiseliova, AA; Vasiliev, KY, 2008) |
| "A mixture of mitochondrial substrates of succinic and malic acids more effectively than antihypoxant trimetazidine prevented functional and metabolic disorders in rat myocardium during acute ischemia: reduces T wave amplitude, QT interval, number and duration of arrhythmias, and restores oxidation-phosphorylation coupling." | 3.74 | Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia. ( Chernyschova, GA; Khazanov, VA; Kiseliova, AA; Vasiliev, KY, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Banke, NH | 1 |
| Lewandowski, ED | 2 |
| Khazanov, VA | 1 |
| Kiseliova, AA | 1 |
| Vasiliev, KY | 1 |
| Chernyschova, GA | 1 |
| Kurian, GA | 1 |
| Berenshtein, E | 1 |
| Kakhlon, O | 1 |
| Chevion, M | 1 |
| Monteiro, P | 1 |
| Duarte, A | 1 |
| Moreno, A | 1 |
| Gonçalves, L | 1 |
| Providência, LA | 1 |
| Zhou, L | 1 |
| Stanley, WC | 1 |
| Saidel, GM | 1 |
| Yu, X | 1 |
| Cabrera, ME | 1 |
| O'Donnell, JM | 1 |
| White, LT | 1 |
| Venditti, P | 1 |
| Masullo, P | 1 |
| Di Meo, S | 1 |
7 other studies available for malic acid and Myocardial Ischemia
| Article | Year |
|---|---|
Impaired cytosolic NADH shuttling and elevated UCP3 contribute to inefficient citric acid cycle flux support of postischemic cardiac work in diabetic hearts.
Topics: Animals; Aspartic Acid; Carbon-13 Magnetic Resonance Spectroscopy; Carrier Proteins; Citric Acid Cyc | 2015 |
Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Coronary Occlusion; Drug | 2008 |
Energy status determines the distinct biochemical and physiological behavior of interfibrillar and sub-sarcolemmal mitochondria.
Topics: Animals; Cell Respiration; Energy Metabolism; Glutamic Acid; Ischemic Preconditioning; Malates; Male | 2012 |
Pyruvate improves mitochondrial bioenergetics in an ex-vivo animal model of myocardial ischemia.
Topics: Animals; Ascorbic Acid; Chemotherapy, Cancer, Regional Perfusion; Female; Glutamic Acid; Intracellul | 2003 |
Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies.
Topics: Animals; Aspartic Acid; Computer Simulation; Cytosol; Energy Metabolism; Glycolysis; Humans; Ischemi | 2005 |
Mitochondrial transporter responsiveness and metabolic flux homeostasis in postischemic hearts.
Topics: Animals; Aspartic Acid; Biological Transport; Malates; Mitochondria, Heart; Myocardial Contraction; | 1999 |
Effects of myocardial ischemia and reperfusion on mitochondrial function and susceptibility to oxidative stress.
Topics: Animals; Dose-Response Relationship, Drug; Hydrogen Peroxide; Lipid Peroxidation; Malates; Male; Mit | 2001 |