malic acid has been researched along with Mitochondrial Diseases in 6 studies
malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.
2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diagnosis of mitochondrial disorders usually requires a muscle biopsy to examine mitochondrial function." | 1.33 | Measurement of the energy-generating capacity of human muscle mitochondria: diagnostic procedure and application to human pathology. ( Janssen, AJ; Morava, E; Rodenburg, RJ; Ruitenbeek, W; Sengers, RC; Smeitink, JA; Trijbels, FJ; van den Heuvel, LP; van Engelen, BG; Wintjes, LT, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iannetti, EF | 1 |
| Smeitink, JAM | 1 |
| Willems, PHGM | 1 |
| Beyrath, J | 1 |
| Koopman, WJH | 1 |
| Roe, CR | 1 |
| Brunengraber, H | 1 |
| Thaveau, F | 1 |
| Zoll, J | 1 |
| Bouitbir, J | 1 |
| Ribera, F | 1 |
| Di Marco, P | 1 |
| Chakfe, N | 1 |
| Kretz, JG | 1 |
| Piquard, F | 1 |
| Geny, B | 1 |
| Jonckheere, AI | 1 |
| Huigsloot, M | 1 |
| Janssen, AJ | 2 |
| Kappen, AJ | 1 |
| Smeitink, JA | 2 |
| Rodenburg, RJ | 2 |
| Llorente-Folch, I | 1 |
| Sahún, I | 1 |
| Contreras, L | 1 |
| Casarejos, MJ | 1 |
| Grau, JM | 1 |
| Saheki, T | 1 |
| Mena, MA | 1 |
| Satrústegui, J | 1 |
| Dierssen, M | 1 |
| Pardo, B | 1 |
| Trijbels, FJ | 1 |
| Sengers, RC | 1 |
| Wintjes, LT | 1 |
| Ruitenbeek, W | 1 |
| Morava, E | 1 |
| van Engelen, BG | 1 |
| van den Heuvel, LP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2A/2B Placebo-controlled Randomised Clinical Trial to Test the Ability of Triheptanoin to Protect Primary Airway Epithelial Cells Obtained From Participants With Ataxia-telangiectasia Against Death Induced by Glucose Deprivation[NCT04513002] | Phase 2 | 30 participants (Actual) | Interventional | 2022-03-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for malic acid and Mitochondrial Diseases
| Article | Year |
|---|---|
Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD
Topics: Adenosine Triphosphate; Aspartic Acid; Cell Death; Culture Media; Electron Transport Complex I; Fibr | 2018 |
Anaplerotic treatment of long-chain fat oxidation disorders with triheptanoin: Review of 15 years Experience.
Topics: Administration, Oral; Adolescent; Adult; Carnitine; Child; Child, Preschool; Citric Acid; Fatty Acid | 2015 |
Contralateral leg as a control during skeletal muscle ischemia-reperfusion.
Topics: Animals; Ascorbic Acid; Cell Respiration; Electron Transport Chain Complex Proteins; Glutamic Acid; | 2009 |
High-throughput assay to measure oxygen consumption in digitonin-permeabilized cells of patients with mitochondrial disorders.
Topics: Cell Membrane Permeability; Cell Respiration; Cells, Cultured; Digitonin; Fibroblasts; Fluorescence; | 2010 |
AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway.
Topics: Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Corpus Striatum; Dopamine | 2013 |
Measurement of the energy-generating capacity of human muscle mitochondria: diagnostic procedure and application to human pathology.
Topics: Adenosine Triphosphate; Adolescent; Adult; Biopsy; Carbon Radioisotopes; Carnitine; Child; Child, Pr | 2006 |