malic acid has been researched along with Electron Transport Chain Deficiencies, Mitochondrial in 6 studies
malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.
2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diagnosis of mitochondrial disorders usually requires a muscle biopsy to examine mitochondrial function." | 1.33 | Measurement of the energy-generating capacity of human muscle mitochondria: diagnostic procedure and application to human pathology. ( Janssen, AJ; Morava, E; Rodenburg, RJ; Ruitenbeek, W; Sengers, RC; Smeitink, JA; Trijbels, FJ; van den Heuvel, LP; van Engelen, BG; Wintjes, LT, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iannetti, EF | 1 |
| Smeitink, JAM | 1 |
| Willems, PHGM | 1 |
| Beyrath, J | 1 |
| Koopman, WJH | 1 |
| Roe, CR | 1 |
| Brunengraber, H | 1 |
| Thaveau, F | 1 |
| Zoll, J | 1 |
| Bouitbir, J | 1 |
| Ribera, F | 1 |
| Di Marco, P | 1 |
| Chakfe, N | 1 |
| Kretz, JG | 1 |
| Piquard, F | 1 |
| Geny, B | 1 |
| Jonckheere, AI | 1 |
| Huigsloot, M | 1 |
| Janssen, AJ | 2 |
| Kappen, AJ | 1 |
| Smeitink, JA | 2 |
| Rodenburg, RJ | 2 |
| Llorente-Folch, I | 1 |
| Sahún, I | 1 |
| Contreras, L | 1 |
| Casarejos, MJ | 1 |
| Grau, JM | 1 |
| Saheki, T | 1 |
| Mena, MA | 1 |
| Satrústegui, J | 1 |
| Dierssen, M | 1 |
| Pardo, B | 1 |
| Trijbels, FJ | 1 |
| Sengers, RC | 1 |
| Wintjes, LT | 1 |
| Ruitenbeek, W | 1 |
| Morava, E | 1 |
| van Engelen, BG | 1 |
| van den Heuvel, LP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2A/2B Placebo-controlled Randomised Clinical Trial to Test the Ability of Triheptanoin to Protect Primary Airway Epithelial Cells Obtained From Participants With Ataxia-telangiectasia Against Death Induced by Glucose Deprivation[NCT04513002] | Phase 2 | 30 participants (Actual) | Interventional | 2022-03-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for malic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD
Topics: Adenosine Triphosphate; Aspartic Acid; Cell Death; Culture Media; Electron Transport Complex I; Fibr | 2018 |
Anaplerotic treatment of long-chain fat oxidation disorders with triheptanoin: Review of 15 years Experience.
Topics: Administration, Oral; Adolescent; Adult; Carnitine; Child; Child, Preschool; Citric Acid; Fatty Acid | 2015 |
Contralateral leg as a control during skeletal muscle ischemia-reperfusion.
Topics: Animals; Ascorbic Acid; Cell Respiration; Electron Transport Chain Complex Proteins; Glutamic Acid; | 2009 |
High-throughput assay to measure oxygen consumption in digitonin-permeabilized cells of patients with mitochondrial disorders.
Topics: Cell Membrane Permeability; Cell Respiration; Cells, Cultured; Digitonin; Fibroblasts; Fluorescence; | 2010 |
AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway.
Topics: Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Corpus Striatum; Dopamine | 2013 |
Measurement of the energy-generating capacity of human muscle mitochondria: diagnostic procedure and application to human pathology.
Topics: Adenosine Triphosphate; Adolescent; Adult; Biopsy; Carbon Radioisotopes; Carnitine; Child; Child, Pr | 2006 |