malic acid has been researched along with Disease Models, Animal in 19 studies
malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.
2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Angiotensin II (AngII)-induced superoxide (O2(•-)) production by the NADPH oxidases and mitochondria has been implicated in the pathogenesis of endothelial dysfunction and hypertension." | 7.80 | Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension. ( Bikineyeva, A; Dikalov, SI; Dikalova, AE; Griendling, KK; Harrison, DG; Hilenski, L; Lassègue, B; Nazarewicz, RR, 2014) |
| "Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state." | 7.77 | Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011) |
| "Angiotensin II (AngII)-induced superoxide (O2(•-)) production by the NADPH oxidases and mitochondria has been implicated in the pathogenesis of endothelial dysfunction and hypertension." | 3.80 | Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension. ( Bikineyeva, A; Dikalov, SI; Dikalova, AE; Griendling, KK; Harrison, DG; Hilenski, L; Lassègue, B; Nazarewicz, RR, 2014) |
| "Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state." | 3.77 | Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011) |
| "Mice null for desmin develop dilated cardiomyopathy characterized by extensive cardiomyocyte death, fibrosis, calcification and eventual heart failure." | 1.33 | Alterations in the heart mitochondrial proteome in a desmin null heart failure model. ( Capetanaki, Y; Fountoulakis, M; Maris, A; Mavroidis, M; Rapti, K; Soumaka, E; Tsangaris, G; Weisleder, N, 2005) |
| "Mice with juvenile visceral steatosis (JVS) develop remarkable cardiac hypertrophy and exhibit an increased number of mitochondria in their heart." | 1.32 | Functional disorders of the oxidative phosphorylation system in the heart mitochondria of mice with juvenile visceral steatosis. ( Arakaki, N; Higuti, T; Himeda, T; Kuwajima, M; Morokami, K; Shibata, H; Suenaga, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Belosludtseva, NV | 1 |
| Kireeva, TA | 1 |
| Belosludtsev, KN | 1 |
| Khunderyakova, NV | 1 |
| Mironova, GD | 1 |
| Mueller, F | 1 |
| Teloh-Benger, JK | 1 |
| Hussmann, B | 1 |
| Lendemans, S | 1 |
| Waack, IN | 1 |
| Yang, MJ | 1 |
| Cheng, ZX | 1 |
| Jiang, M | 1 |
| Zeng, ZH | 1 |
| Peng, B | 1 |
| Peng, XX | 1 |
| Li, H | 1 |
| Bakermans, AJ | 1 |
| Dodd, MS | 1 |
| Nicolay, K | 1 |
| Prompers, JJ | 1 |
| Tyler, DJ | 1 |
| Houten, SM | 1 |
| Dikalov, SI | 1 |
| Nazarewicz, RR | 1 |
| Bikineyeva, A | 1 |
| Hilenski, L | 1 |
| Lassègue, B | 1 |
| Griendling, KK | 1 |
| Harrison, DG | 1 |
| Dikalova, AE | 1 |
| Chouchani, ET | 1 |
| Pell, VR | 1 |
| Gaude, E | 1 |
| Aksentijević, D | 1 |
| Sundier, SY | 1 |
| Robb, EL | 1 |
| Logan, A | 1 |
| Nadtochiy, SM | 1 |
| Ord, ENJ | 1 |
| Smith, AC | 1 |
| Eyassu, F | 1 |
| Shirley, R | 1 |
| Hu, CH | 1 |
| Dare, AJ | 1 |
| James, AM | 1 |
| Rogatti, S | 1 |
| Hartley, RC | 1 |
| Eaton, S | 1 |
| Costa, ASH | 1 |
| Brookes, PS | 1 |
| Davidson, SM | 1 |
| Duchen, MR | 1 |
| Saeb-Parsy, K | 1 |
| Shattock, MJ | 1 |
| Robinson, AJ | 1 |
| Work, LM | 1 |
| Frezza, C | 1 |
| Krieg, T | 1 |
| Murphy, MP | 1 |
| Feng, W | 1 |
| Zhao, T | 1 |
| Mao, G | 1 |
| Wang, W | 1 |
| Feng, Y | 1 |
| Li, F | 1 |
| Zheng, D | 1 |
| Wu, H | 1 |
| Jin, D | 1 |
| Yang, L | 1 |
| Wu, X | 1 |
| Kayser, EB | 1 |
| Sedensky, MM | 1 |
| Morgan, PG | 1 |
| Tian, Z | 1 |
| Liu, Y | 1 |
| Usa, K | 1 |
| Mladinov, D | 1 |
| Fang, Y | 1 |
| Ding, X | 1 |
| Greene, AS | 1 |
| Cowley, AW | 1 |
| Liang, M | 1 |
| Rendon, DA | 1 |
| Alvarez-Bustamante, JA | 1 |
| Bienholz, A | 1 |
| Petrat, F | 1 |
| Wenzel, P | 1 |
| Ickerott, P | 1 |
| Weinberg, JM | 1 |
| Witzke, O | 1 |
| Kribben, A | 1 |
| de Groot, H | 1 |
| Feldkamp, T | 1 |
| Roušar, T | 1 |
| Nýdlová, E | 1 |
| Česla, P | 1 |
| Staňková, P | 1 |
| Kučera, O | 1 |
| Pařík, P | 1 |
| Červinková, Z | 1 |
| Stanely Mainzen Prince, P | 1 |
| Suenaga, M | 1 |
| Arakaki, N | 1 |
| Morokami, K | 1 |
| Himeda, T | 1 |
| Shibata, H | 1 |
| Kuwajima, M | 1 |
| Higuti, T | 1 |
| Fountoulakis, M | 1 |
| Soumaka, E | 1 |
| Rapti, K | 1 |
| Mavroidis, M | 1 |
| Tsangaris, G | 1 |
| Maris, A | 1 |
| Weisleder, N | 1 |
| Capetanaki, Y | 1 |
| Siakotos, AN | 1 |
| Blair, PS | 1 |
| Savill, JD | 1 |
| Katz, ML | 1 |
| Sivan, VM | 1 |
| Kaleysa Raj, R | 1 |
| Xu, GP | 1 |
| Dave, KR | 1 |
| Moraes, CT | 1 |
| Busto, R | 1 |
| Sick, TJ | 1 |
| Bradley, WG | 1 |
| Pérez-Pinzón, MA | 1 |
| Roth, KS | 1 |
| Carter, BE | 1 |
| Higgins, ES | 1 |
19 other studies available for malic acid and Disease Models, Animal
| Article | Year |
|---|---|
Comparative Study of Functional Changes in Heart Mitochondria in Two Modes of Epinephrine Exposure Modeling Myocardial Injury in Rats.
Topics: Adenosine Triphosphate; Animals; Calcium; Cardiomyopathies; Cations, Divalent; Disease Models, Anima | 2021 |
Malate Protects the Kidneys From Hemorrhagic Shock-Induced Injury in an Experimental Rat Model.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Fluid Therapy; Humans; Infusions, Intravenous; | 2020 |
Boosted TCA cycle enhances survival of zebrafish to Vibrio alginolyticus infection.
Topics: Animals; Citric Acid Cycle; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Ketoglutar | 2018 |
Myocardial energy shortage and unmet anaplerotic needs in the fasted long-chain acyl-CoA dehydrogenase knockout mouse.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Aspartic Acid; Citric Acid Cycle; Disease Models, Anima | 2013 |
Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension.
Topics: Angiotensin II; Animals; CSK Tyrosine-Protein Kinase; Cyclic N-Oxides; Cytoplasm; Disease Models, An | 2014 |
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Topics: Adenosine Monophosphate; Animals; Aspartic Acid; Citric Acid Cycle; Disease Models, Animal; Electron | 2014 |
Type 2 diabetic rats on diet supplemented with chromium malate show improved glycometabolism, glycometabolism-related enzyme levels and lipid metabolism.
Topics: Animals; Biological Transport; Blood Glucose; Body Weight; Chromium; Diabetes Mellitus, Experimental | 2015 |
Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain.
Topics: Animals; Brain Stem; Cell Respiration; Cerebellum; Disease Models, Animal; Electron Transport Comple | 2016 |
Novel role of fumarate metabolism in dahl-salt sensitive hypertension.
Topics: Analysis of Variance; Animals; Biomarkers; Blotting, Western; Disease Models, Animal; DNA, Complemen | 2009 |
Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes?
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease | 2011 |
Adverse effects of α-ketoglutarate/malate in a rat model of acute kidney injury.
Topics: Acute Kidney Injury; Animals; Blood Pressure; Cell Adhesion Molecules; Disease Models, Animal; Heart | 2012 |
Purified acetaminophen-glutathione conjugate is able to induce oxidative stress in rat liver mitochondria.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Respons | 2012 |
(-) Epicatechin attenuates mitochondrial damage by enhancing mitochondrial multi-marker enzymes, adenosine triphosphate and lowering calcium in isoproterenol induced myocardial infarcted rats.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Biomarkers; Calcium; Catechin; Citric Acid Cycle; Cre | 2013 |
Functional disorders of the oxidative phosphorylation system in the heart mitochondria of mice with juvenile visceral steatosis.
Topics: Adenosine Triphosphatases; Animals; Blotting, Western; Cardiomegaly; Cytochromes; Disease Models, An | 2003 |
Alterations in the heart mitochondrial proteome in a desmin null heart failure model.
Topics: Acetic Acid; Amino Acids; Animals; Aspartic Acid; Cardiomyopathy, Dilated; Databases, Protein; Desmi | 2005 |
Altered mitochondrial function in canine ceroid-lipofuscinosis.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Disease Models, Animal; Dogs; Glutamic Acid; | 1998 |
Quinone analogue irrecoverably paralyses the filarial parasites in vitro.
Topics: Animals; Benzoquinones; Cattle; Disease Models, Animal; Dose-Response Relationship, Drug; Electron T | 1999 |
Dysfunctional mitochondrial respiration in the wobbler mouse brain.
Topics: Amyotrophic Lateral Sclerosis; Animals; Ascorbic Acid; Brain; Cell Respiration; Disease Models, Anim | 2001 |
Succinylacetone effects on renal tubular phosphate metabolism: a model for experimental renal Fanconi syndrome.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Disease Models, Animal; Fanconi Syndrome; Glutamat | 1991 |