malic acid has been researched along with Diabetes Mellitus, Adult-Onset in 6 studies
malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.
2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The metabolic alterations of type 2 diabetes are associated with protection against IR injury at onset but detrimental effects in late diabetes mellitus consistent with progressive dysfunction of glucose oxidation." | 1.39 | Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation. ( Birkler, RI; Bøtker, HE; Dalgas, C; Johannsen, M; Løfgren, B; Povlsen, JA; Støttrup, NB, 2013) |
| "The pathogenesis of type 2 diabetes is characterized by impaired insulin action and increased hepatic glucose production (HGP)." | 1.39 | In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model. ( Han, W; Lee, P; Leong, W; Lim, M; Radda, GK; Tan, T, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Povlsen, JA | 1 |
| Løfgren, B | 1 |
| Dalgas, C | 1 |
| Birkler, RI | 1 |
| Johannsen, M | 1 |
| Støttrup, NB | 1 |
| Bøtker, HE | 1 |
| Feng, W | 1 |
| Zhao, T | 1 |
| Mao, G | 1 |
| Wang, W | 1 |
| Feng, Y | 1 |
| Li, F | 1 |
| Zheng, D | 1 |
| Wu, H | 1 |
| Jin, D | 1 |
| Yang, L | 1 |
| Wu, X | 1 |
| Lee, P | 1 |
| Leong, W | 1 |
| Tan, T | 1 |
| Lim, M | 1 |
| Han, W | 1 |
| Radda, GK | 1 |
| Ladrière, L | 1 |
| Malaisse-Lagae, F | 1 |
| Verbruggen, I | 1 |
| Willem, R | 1 |
| Malaisse, WJ | 1 |
| Song, DK | 1 |
| Ahn, YH | 1 |
| Bae, JH | 1 |
| Park, WK | 1 |
| Hong, YS | 1 |
| Ho, WK | 1 |
| Earm, YE | 1 |
| Deaver, OE | 1 |
| Wander, RC | 1 |
| McCusker, RH | 1 |
| Berdanier, CD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway (HP FFF)[NCT03480594] | 30 participants (Anticipated) | Observational | 2018-10-01 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for malic acid and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation.
Topics: Animals; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Glucose; Heart Function Tests; Hem | 2013 |
Type 2 diabetic rats on diet supplemented with chromium malate show improved glycometabolism, glycometabolism-related enzyme levels and lipid metabolism.
Topics: Animals; Biological Transport; Blood Glucose; Body Weight; Chromium; Diabetes Mellitus, Experimental | 2015 |
In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2013 |
Effects of starvation and diabetes on the metabolism of [2,3-13C]succinic acid dimethyl ester in rat hepatocytes.
Topics: Animals; Carbon Isotopes; Diabetes Mellitus, Type 2; Female; Glucose; Lactic Acid; Liver; Malates; R | 1999 |
Evidence of enhancement of malate-aspartate shuttle activity in beta cells of streptozotocin-induced non-insulin-dependent diabetic rats.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Blood Glucose; Cells, Cultured; Diabetes Mellitus, E | 2000 |
Diet effects on membrane phospholipid fatty acids and mitochondrial function in BHE rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Aspartic Acid; Coconut Oil; Corn Oil; Dia | 1986 |