malic acid has been researched along with Amyotrophic Lateral Sclerosis in 3 studies
malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.
2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mali, Y | 2 |
| Zisapels, N | 1 |
| Zisapel, N | 1 |
| Xu, GP | 1 |
| Dave, KR | 1 |
| Moraes, CT | 1 |
| Busto, R | 1 |
| Sick, TJ | 1 |
| Bradley, WG | 1 |
| Pérez-Pinzón, MA | 1 |
3 other studies available for malic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Gain of interaction of ALS-linked G93A superoxide dismutase with cytosolic malate dehydrogenase.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Line; Cytosol; Humans; Malate Dehydrogen | 2008 |
VEGF up-regulation by G93A superoxide dismutase and the role of malate-aspartate shuttle inhibition.
Topics: Aminooxyacetic Acid; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Carbon Dioxide; Cell Lin | 2010 |
Dysfunctional mitochondrial respiration in the wobbler mouse brain.
Topics: Amyotrophic Lateral Sclerosis; Animals; Ascorbic Acid; Brain; Cell Respiration; Disease Models, Anim | 2001 |