malic acid has been researched along with Alloxan Diabetes in 14 studies
malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.
2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state." | 7.77 | Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011) |
| "Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state." | 3.77 | Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011) |
| "Vanadium complexes have been studied for the treatment of diabetes." | 1.72 | Heteroleptic oxidovanadium(IV)-malate complex improves glucose uptake in HepG2 and enhances insulin action in streptozotocin-induced diabetic rats. ( Bottini, RCR; da Cunha, JM; de Nigro, TP; de Souza, SW; Jesus, CHA; Manica, GCM; Missina, JM; Nunes, GG; Picheth, G; Rego, FGM; Valdameri, G, 2022) |
| " The results showed that no pathological, toxic feces and urine changes were observed in clinical signs of parental and fetal rats in chromium malate groups." | 1.42 | Evaluation of the Reproductive Toxicity, Glycometabolism, Glycometabolism-Related Enzyme Levels and Lipid Metabolism of Chromium Malate Supplementation in Sprague-Dawley Rats. ( Bao, Y; Feng, W; Huang, J; Mao, G; Wang, W; Wu, X; Yang, L; Zhang, W; Zhao, T; Zhou, Z, 2015) |
| "The pathogenesis of type 2 diabetes is characterized by impaired insulin action and increased hepatic glucose production (HGP)." | 1.39 | In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model. ( Han, W; Lee, P; Leong, W; Lim, M; Radda, GK; Tan, T, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| de Nigro, TP | 1 |
| Manica, GCM | 1 |
| de Souza, SW | 1 |
| Jesus, CHA | 1 |
| Bottini, RCR | 1 |
| Missina, JM | 1 |
| Valdameri, G | 1 |
| Nunes, GG | 1 |
| da Cunha, JM | 1 |
| Picheth, G | 1 |
| Rego, FGM | 1 |
| Banke, NH | 1 |
| Lewandowski, ED | 1 |
| Feng, W | 2 |
| Zhang, W | 1 |
| Zhao, T | 2 |
| Mao, G | 2 |
| Wang, W | 2 |
| Wu, X | 3 |
| Zhou, Z | 1 |
| Huang, J | 1 |
| Bao, Y | 1 |
| Yang, L | 2 |
| Feng, Y | 1 |
| Li, F | 1 |
| Zheng, D | 1 |
| Wu, H | 1 |
| Jin, D | 1 |
| Rendon, DA | 1 |
| Alvarez-Bustamante, JA | 1 |
| Lee, P | 1 |
| Leong, W | 1 |
| Tan, T | 1 |
| Lim, M | 1 |
| Han, W | 1 |
| Radda, GK | 1 |
| BEATTY, CH | 1 |
| WEST, ES | 1 |
| Winiarska, K | 1 |
| Drozak, J | 1 |
| Wegrzynowicz, M | 1 |
| Fraczyk, T | 1 |
| Bryla, J | 1 |
| Song, DK | 1 |
| Ahn, YH | 1 |
| Bae, JH | 1 |
| Park, WK | 1 |
| Hong, YS | 1 |
| Ho, WK | 1 |
| Earm, YE | 1 |
| Deaver, OE | 1 |
| Wander, RC | 1 |
| McCusker, RH | 1 |
| Berdanier, CD | 1 |
| Sussman, I | 1 |
| Matschinsky, FM | 1 |
| Boquist, L | 1 |
| Ericsson, I | 1 |
| Lorentzon, R | 1 |
| Nelson, L | 1 |
| Kazmi, SM | 1 |
| Mayanil, CS | 1 |
| Baquer, NZ | 1 |
| Kuo, TH | 1 |
| Giacomelli, F | 1 |
| Wiener, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway (HP FFF)[NCT03480594] | 30 participants (Anticipated) | Observational | 2018-10-01 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 other studies available for malic acid and Alloxan Diabetes
| Article | Year |
|---|---|
Heteroleptic oxidovanadium(IV)-malate complex improves glucose uptake in HepG2 and enhances insulin action in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Insulin; Malat | 2022 |
Impaired cytosolic NADH shuttling and elevated UCP3 contribute to inefficient citric acid cycle flux support of postischemic cardiac work in diabetic hearts.
Topics: Animals; Aspartic Acid; Carbon-13 Magnetic Resonance Spectroscopy; Carrier Proteins; Citric Acid Cyc | 2015 |
Evaluation of the Reproductive Toxicity, Glycometabolism, Glycometabolism-Related Enzyme Levels and Lipid Metabolism of Chromium Malate Supplementation in Sprague-Dawley Rats.
Topics: Animals; Chromium Compounds; Diabetes Mellitus, Experimental; Dietary Supplements; Dose-Response Rel | 2015 |
Type 2 diabetic rats on diet supplemented with chromium malate show improved glycometabolism, glycometabolism-related enzyme levels and lipid metabolism.
Topics: Animals; Biological Transport; Blood Glucose; Body Weight; Chromium; Diabetes Mellitus, Experimental | 2015 |
Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes?
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease | 2011 |
In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2013 |
Effect of succinic and malic acids and fructose on ketosis in alloxan-diabetic rats.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Fructose; Ketosis; Malates; Rats; Succinates | 1955 |
Diabetes-induced changes in glucose synthesis, intracellular glutathione status and hydroxyl free radical generation in rabbit kidney-cortex tubules.
Topics: Animals; Catechols; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Glucose-6-Phosphate; | 2004 |
Evidence of enhancement of malate-aspartate shuttle activity in beta cells of streptozotocin-induced non-insulin-dependent diabetic rats.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Blood Glucose; Cells, Cultured; Diabetes Mellitus, E | 2000 |
Diet effects on membrane phospholipid fatty acids and mitochondrial function in BHE rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Aspartic Acid; Coconut Oil; Corn Oil; Dia | 1986 |
Diabetes affects sorbitol and myo-inositol levels of neuroectodermal tissue during embryogenesis in rat.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Body Weight; Creatine; Diabetes Mellitus, Ex | 1988 |
Alterations in mitochondrial aconitase activity and respiration, and in concentration of citrate in some organs of mice with experimental or genetic diabetes.
Topics: Aconitate Hydratase; Animals; Citrates; Citric Acid; Diabetes Mellitus, Experimental; Female; Islets | 1985 |
Malate-aspartate shuttle enzymes in rat brain regions, liver and heart during alloxan diabetes and insulin replacement.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Brain; Brain Stem; Cerebellum; Diabetes Mellitu | 1985 |
Oxidative metabolism of Polytron versus Nagarse mitochondria in hearts of genetically diabetic mice.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyl-CoA C-Acyltransferase; Animals; Cell Fractionation; Diabete | 1985 |