malic acid has been researched along with Aging in 19 studies
malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.
2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study examined whether chronic intake of polyphenols (PPs), which are known to be modulators of oxidative stress, might prevent the age-related decline of mitochondrial functions in skeletal muscle." | 1.39 | Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production. ( Auger, C; Charles, AL; Dal-Ros, S; Geny, B; Keller, N; Metzger, D; Meyer, A; Ramamoorthy, TG; Schini-Kerth, V; Zoll, J, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Donato, AJ | 1 |
| Henson, GD | 1 |
| Hart, CR | 1 |
| Layec, G | 1 |
| Trinity, JD | 1 |
| Bramwell, RC | 1 |
| Enz, RA | 1 |
| Morgan, RG | 1 |
| Reihl, KD | 1 |
| Hazra, S | 1 |
| Walker, AE | 1 |
| Richardson, RS | 1 |
| Lesniewski, LA | 1 |
| Zeng, X | 1 |
| Wu, J | 1 |
| Wu, Q | 1 |
| Zhang, J | 1 |
| Hagopian, K | 2 |
| Ramsey, JJ | 2 |
| Weindruch, R | 2 |
| Charles, AL | 1 |
| Meyer, A | 1 |
| Dal-Ros, S | 1 |
| Auger, C | 1 |
| Keller, N | 1 |
| Ramamoorthy, TG | 1 |
| Zoll, J | 1 |
| Metzger, D | 1 |
| Schini-Kerth, V | 1 |
| Geny, B | 1 |
| St-Pierre, J | 1 |
| Buckingham, JA | 1 |
| Roebuck, SJ | 1 |
| Brand, MD | 1 |
| SMITH, RM | 1 |
| OSBORNE-WHITE, WS | 1 |
| RUSSELL, GR | 1 |
| Stuart, JA | 1 |
| Bourque, BM | 1 |
| de Souza-Pinto, NC | 1 |
| Bohr, VA | 1 |
| Sethumadhavan, S | 1 |
| Chinnakannu, P | 1 |
| Horton, AA | 1 |
| Spencer, JA | 1 |
| Deshmukh, DR | 1 |
| Patel, MS | 1 |
| Aruldhas, MM | 1 |
| Valivullah, HM | 1 |
| Govindarajulu, P | 1 |
| Berthon, P | 1 |
| Freyssenet, D | 1 |
| Chatard, JC | 1 |
| Castells, J | 1 |
| Mujika, I | 1 |
| Geyssant, A | 1 |
| Guezennec, CY | 1 |
| Denis, C | 1 |
| Boffoli, D | 1 |
| Scacco, SC | 1 |
| Vergari, R | 1 |
| Solarino, G | 1 |
| Santacroce, G | 1 |
| Papa, S | 1 |
| Sastre, J | 1 |
| Pallardó, FV | 1 |
| Plá, R | 1 |
| Pellín, A | 1 |
| Juan, G | 1 |
| O'Connor, JE | 1 |
| Estrela, JM | 1 |
| Miquel, J | 1 |
| Viña, J | 1 |
| Rosebrough, RW | 1 |
| Mitchell, AD | 1 |
| McMurtry, JP | 1 |
| López-Torres, M | 1 |
| Gredilla, R | 1 |
| Sanz, A | 1 |
| Barja, G | 1 |
| Sharma, R | 1 |
| Dey, S | 1 |
| Verma, R | 1 |
| Hoyer, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combining Vitamin E-functionalized CHOcolate With Physical Exercise to Reduce the risK Of Protein Energy Malnutrition in Pre-dementia AGEd People[NCT05343611] | 102 participants (Anticipated) | Interventional | 2022-05-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 other studies available for malic acid and Aging
| Article | Year |
|---|---|
The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction.
Topics: Adipose Tissue; Aging; Animals; Arteries; Body Weight; Carnitine; Glutamic Acid; Malates; Male; Mice | 2014 |
L-malate enhances the gene expression of carried proteins and antioxidant enzymes in liver of aged rats.
Topics: Age Factors; Aging; Amino Acid Transport Systems, Acidic; Animals; Antioxidants; Antiporters; Carrie | 2015 |
Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver.
Topics: Age Factors; Aging; Aldehyde Reductase; Animals; Caloric Restriction; Fructose; Glucose; L-Iditol 2- | 2009 |
Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production.
Topics: Administration, Oral; Age Factors; Aging; Animals; Antioxidants; Ascorbic Acid; Electron Transport C | 2013 |
Topology of superoxide production from different sites in the mitochondrial electron transport chain.
Topics: Aging; Animals; Antimycin A; Columbidae; Electron Transport; Enzyme Inhibitors; Female; Hydrogen Per | 2002 |
METABOLISM OF PROPIONATE BY SHEEP LIVER. INTERRELATIONS OF PROPIONATE AND GLUTAMATE IN AGED MITOCHONDRIA.
Topics: Acyl Coenzyme A; Aging; Amino Acids; Animals; Aspartic Acid; Carbon Dioxide; Citrates; Fatty Acids; | 1965 |
Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction.
Topics: Aging; Animals; Aspartic Acid; Caloric Restriction; Citric Acid; Citric Acid Cycle; Glutamic Acid; K | 2004 |
No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Deoxyguanosine; DNA Glycosylases; DNA, Mitochondrial; F | 2005 |
L-carnitine and alpha-lipoic acid improve age-associated decline in mitochondrial respiratory chain activity of rat heart muscle.
Topics: Aging; Analysis of Variance; Animals; Carnitine; Cell Respiration; Glutamic Acid; Hydroxybutyrates; | 2006 |
Decline in respiratory control ratio of rat liver mitochondria in old age.
Topics: Adenosine Diphosphate; Aging; Animals; Energy Metabolism; Glutamates; Glutamic Acid; Malates; Mitoch | 1981 |
Age-dependent changes in pyruvate uptake by nonsynaptic and synaptic mitochondria from rat brain.
Topics: Aging; Animals; Brain; Cytochrome c Group; In Vitro Techniques; Malates; Male; Mitochondria; Oxygen | 1982 |
Effect of thyroidectomy on testicular enzymes of the pyruvate/malate cycle involved in lipogenesis.
Topics: Aging; Animals; ATP Citrate (pro-S)-Lyase; Isocitrate Dehydrogenase; Lipids; Malate Dehydrogenase; M | 1983 |
Mitochondrial ATP production rate in 55 to 73-year-old men: effect of endurance training.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Adenosine Triphosphate; Aged; Aging; Carnitine O-Palmitoyltransfer | 1995 |
Decline with age of the respiratory chain activity in human skeletal muscle.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Ascorbic Acid; Cytochromes; Electron Transport Co | 1994 |
Aging of the liver: age-associated mitochondrial damage in intact hepatocytes.
Topics: Aging; Animals; Gluconeogenesis; Liver; Malates; Male; Membrane Lipids; Membrane Potentials; Mitocho | 1996 |
Dietary crude protein changes rapidly alter metabolism and plasma insulin-like growth factor I concentrations in broiler chickens.
Topics: Aging; Analysis of Variance; Animals; Chickens; Diet, Protein-Restricted; Dietary Proteins; Eating; | 1996 |
Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Cell Nucleus; Deoxyguanosine; Diet, Reducing; DNA; DNA | 2002 |
Age-specific development of malate-aspartate shuttle in the liver and kidney of mice.
Topics: Aging; Animals; Aspartate Aminotransferases; Aspartic Acid; Kidney; Liver; Malate Dehydrogenase; Mal | 1992 |
The effect of age on glucose and energy metabolism in brain cortex of rats.
Topics: Adenosine Triphosphate; Aging; Animals; Cerebral Cortex; Citrates; Citric Acid; Energy Metabolism; G | 1985 |