magnesium-trisilicate and Pulmonary-Fibrosis

As the preliminary results of experimental studies on dust from the palygorskite group have led to some confusion a detailed description of the completed investigation is given for clarification. As in other experiments the biological effects have been shown to be associated with the physical characteristics of the fibres in these specimens. Samples of sepiolite and attapulgite from Spain and a single sample of palygorskite from the United Kingdom have been studied. Serious abnormalities were produced only by the palygorskite and one of the attapulgite dusts. The palygorskite is of no commercial interest and the attapulgite was from one small deposit and was used only in the preparation of drilling mud in the exploration of oil deposits.

Topics: Administration, Inhalation; Animals; Dust; Female; Magnesium; Magnesium Compounds; Magnesium Silicates; Male; Mesothelioma; Microscopy, Electron; Minerals; Pleural Neoplasms; Pulmonary Fibrosis; Rats; Rats, Inbred F344; Rats, Inbred Strains; Silicon; Silicon Compounds