magnesium-trisilicate and Kidney-Calculi

A 66-year-old female visited our university hospital with the chief complaint of right lower abdominal pain in July, 1984. Kidney-ureter-bladder roentgenograms disclosed the right ureter stone and several left renal stones. She passed the right ureter stone composed of calcium oxalate. Thereafter, she passed small stones twice and sand stones twice until September, 1985. The stone analysis revealed two of them as silica. Although most patients with silica stones reported in Japan had a history of long-term medication of magnesium trisilicate, this patient had not taken this drug. Silica stones are rare and fifteen cases including the present case have been reported in Japan.

Topics: Aged; Female; Humans; Kidney Calculi; Magnesium; Magnesium Silicates; Radiography; Silicic Acid; Silicon Dioxide; Ureteral Calculi

Two cases of silica stones, without previous oral intake of magnesium trisilicate, are reported. A 64-year-old Japanese woman had bilateral renal stones. Infrared spectrophotoscopy revealed that one of the fragments consisted of silicate and the others consisted of calcium oxalate. A 75-year-old woman had right renal stones. The composition of 1 stone was a mixture of silicate and unspecified matrices. Silicate urolithiasis may not necessarily be related to oral intake of silicate-containing antacids.

Topics: Aged; Antacids; Female; Humans; Kidney Calculi; Magnesium Silicates; Middle Aged; Radiography; Silicon Dioxide; Spectrophotometry, Infrared

We report a case of a 30-year-old female who had a long-term history of trisilicate-containing antacid intake for gastric discomfort. She had experienced repeated attacks of renal colic. Neither intravenous pyelography nor ureteroscopy could define the presence of calculi. The metabolic evaluations were normal. However, X-ray diffraction revealed a silicate stone. We suggest that the attack of renal colic in those patients with long-term history of trisilicate intake should arouse the possibility of silica urolithiasis.

Topics: Administration, Oral; Adult; Antacids; Electron Probe Microanalysis; Female; Humans; Kidney Calculi; Long-Term Care; Magnesium; Magnesium Silicates; Silicic Acid; Silicon Dioxide

Urinary tract silicate calculi are rare. Occurrence is limited strictly to patients who ingest magnesium trisilicate antacids. We report a case of a renal silicate calculus and review the subject of silicate stones.

Topics: Adolescent; Antacids; Humans; Kidney Calculi; Magnesium; Magnesium Silicates; Male; Radiography; Self Medication; Silicic Acid; Silicon Dioxide

A case of acute renal failure apparently caused by ingestion of large amounts of a magnesium-containing antacid is reported. A 51-year-old man was hospitalized with complete anuria and an associated hyperkalemia and hypermagnesemia. He had been taking 25-30 magnesium trisilicate-aluminum hydroxide (Gelusil) tablets daily for several years to relieve symptoms of gastritis. A renal sonogram and a retrograde pyelogram demonstrated the presence of multiple renal stones that were found to be composed of magnesium-ammonium-phosphate crystals. The patients required surgical removal of the stones and placement of ureteral catheters before renal function improved. An intravenous pyelogram performed four weeks after discharge revealed no apparent residual damage. The etiology, incidence, and characteristics of magnesium-ammonium-phosphate stones are discussed. Previous reports of renal stones associated with magnesium-containing antacids are reviewed.

Topics: Acute Kidney Injury; Antacids; Humans; Kidney Calculi; Magnesium; Magnesium Silicates; Male; Middle Aged; Silicic Acid