magnesium-trisilicate and Hypernatremia

Magnesium trisilicate mixture is an antacid used commonly in our Intensive Care Unit in the prevention and treatment of stress ulcers. In this case the administration of large doses over a period of time led to the development of massive hyperosmolality, cerebral dehydration and coma. Management with hypotonic fluid resulted in complete recovery.

Topics: Antacids; Coma; Fluid Therapy; Humans; Hypernatremia; Magnesium; Magnesium Silicates; Male; Middle Aged; Osmolar Concentration; Silicic Acid; Silicon Dioxide; Sodium