magnesium-citrate--potassium-citrate--pyridoxine-hcl--sodium-citrate-drug-combination and Urinary-Calculi

Hypocitraturia, hypercalciuria, hypokalaemia, and some form of acidosis are often characteristic accompanying symptoms of calcium containing urinary stone formation. These alterations may be controlled or normalized with the administration of alkaline citrates which slow the relative growth rate of calcium oxalate crystals down. In response to the administration of a single 2-g dose of Magurlit granulate, also regarded as alkaline citrate, citrate excretion increases, urinary Ca/citrate, Ca/creatinine, and Ca.P/creatinine quotients decrease. Since these changes of the urinary constituents are advantageous as far as the prophylaxis of stone formation is considered and may be observed following the administration of other citrate mixtures as well the application of Magurlit is recommended for the prevention of calcium oxalate stones and for the treatment of distal renal tubular acidosis.

Topics: Citrates; Drug Combinations; Female; Humans; Male; Oxalates; Pyridoxine; Urinary Calculi

Topics: Adult; Aged; Aged, 80 and over; Calcium Oxalate; Citrates; Drug Combinations; Humans; Middle Aged; Pyridoxine; Time Factors; Uric Acid; Urinary Calculi

Topics: Adult; Aged; Citrates; Drug Combinations; Female; Humans; Male; Middle Aged; Pyridoxine; Uric Acid; Urinary Calculi

Topics: Citrates; Drug Combinations; Humans; Hydrogen-Ion Concentration; Pyridoxine; Recurrence; Uric Acid; Urinary Calculi

Topics: Aged; Citrates; Drug Combinations; Humans; Middle Aged; Pyridoxine; Urinary Calculi

Topics: Citrates; Drug Combinations; Female; Humans; Kidney Calculi; Male; Pyridoxine; Ureteral Calculi; Urinary Bladder Calculi; Urinary Calculi

Three different combinations--the Eisenberg solution, Uralyt-U and Magurlit--have been compared for their litholytic effect on urate calculi in a homogeneous patient material. Magurlit and Uralyt-U have been found superior to the Eisenberg solution, insofar as they are dispensed in a hygienic form easy to handle and require for the production of the litholytic pH levels a shorter time than does the Eisenberg solution. In opposition to other citrate combinations, Magurlit may be used with success even if the urate calculus contain an additional component, unless its distribution is unfavourable and its proportion exceeds 15 to 20%.

Topics: Citrates; Drug Combinations; Humans; Hydrogen-Ion Concentration; Pyridoxine; Urinary Calculi

Topics: Citrates; Drug Combinations; Humans; Pyridoxine; Urinary Calculi

Topics: Administration, Oral; Citrates; Drug Combinations; Humans; Hydrogen-Ion Concentration; Pyridoxine; Solubility; Urinary Calculi