macelignan and Learning-Disabilities

macelignan has been researched along with Learning-Disabilities* in 1 studies

Other Studies

1 other study(ies) available for macelignan and Learning-Disabilities

Article	Year
Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats. Neuroscience letters, 2008, Dec-19, Volume: 448, Issue:1 Previous studies have shown that macelignan has anti-inflammatory and neuroprotective effects. Subsequently, in the current study, we demonstrate that oral administrations of macelignan reduce the hippocampal microglial activation induced by chronic infusions of lipopolysaccharide (LPS) into the fourth ventricle of Fisher-344 rat brains. A Morris water maze was used to evaluate the status of the hippocampal-dependent spatial learning in control rats with an artificial cerebrospinal fluid infusion, rats with chronic LPS infusions, and rats with chronic LPS infusions and oral administrations of macelignan. The rats with chronic LPS infusions showed spatial memory impairments relative to the control rats in the performance of the memory task. Daily administration of macelignan reduced the spatial memory impairments induced by the chronic LPS infusions. The results indicate that macelignan may possess therapeutic potential for the prevention of Alzheimer's disease. Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Histocompatibility Antigens Class II; Inflammation; Learning Disabilities; Lignans; Lipopolysaccharides; Male; Maze Learning; Microglia; Rats; Rats, Inbred F344; Reaction Time; Space Perception	2008

Article

Year

Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats.

Neuroscience letters, 2008, Dec-19, Volume: 448, Issue:1

Previous studies have shown that macelignan has anti-inflammatory and neuroprotective effects. Subsequently, in the current study, we demonstrate that oral administrations of macelignan reduce the hippocampal microglial activation induced by chronic infusions of lipopolysaccharide (LPS) into the fourth ventricle of Fisher-344 rat brains. A Morris water maze was used to evaluate the status of the hippocampal-dependent spatial learning in control rats with an artificial cerebrospinal fluid infusion, rats with chronic LPS infusions, and rats with chronic LPS infusions and oral administrations of macelignan. The rats with chronic LPS infusions showed spatial memory impairments relative to the control rats in the performance of the memory task. Daily administration of macelignan reduced the spatial memory impairments induced by the chronic LPS infusions. The results indicate that macelignan may possess therapeutic potential for the prevention of Alzheimer's disease.

Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Histocompatibility Antigens Class II; Inflammation; Learning Disabilities; Lignans; Lipopolysaccharides; Male; Maze Learning; Microglia; Rats; Rats, Inbred F344; Reaction Time; Space Perception

2008