lysyl-glutamyl-aspartic-acid and Disease-Models--Animal

Neuroprotective peptides are promising candidate molecules for the treatment of Alzheimer's disease (AD). Oral application of KED (Lys-Glu-Asp) improved memory and attention in elderly individuals with functional CNS disorders. Peptide KED also restores synaptic plasticity in in vitro model of AD. This review is focused on the analysis of the influence of KED peptide on the expression of genes and synthesis of proteins regulating apoptosis, aging, neurogenesis, and involved in AD pathogenesis. Analysis of published reports and our experimental findings suggests that KED regulates the expression of genes of cell aging and apoptosis (р16, р21), genes (NES, GAP43) and proteins (nestin, GAP43) of the neuronal differentiation, and genes involved in AD pathogenesis (SUMO, APOE, and IGF1). The study the effectiveness of neuroprotective peptide KED in animal models of AD seems to be very important.

Topics: Aged; Aging; Alzheimer Disease; Animals; Cellular Senescence; Disease Models, Animal; Humans; Neurogenesis; Neuronal Plasticity; Oligopeptides; Signal Transduction

This study was devoted to the evaluation of morphofunctional alterations in the pancreas in the conditions of physiological and premature aging using the experimental model of irradiation-induced aging, and the possibility of peptidergic regulation of age-related alterations in the pancreas was also studied. Age-related alterations in the pancreas of old animals in the conditions of physiological aging were revealed in the form of dystrophic alterations of main cell populations, disordered microcirculatory vascular channels and reduced level of physiological regeneration of this organ. In the conditions of irradiation-induced premature aging the above mentioned manifestations of dystrophic alterations in the pancreas tissue were found to be more pronounced. Administration of tripeptide T-38 (Lys-Glu-Asp) to old irradiated animals activated the processes of post-irradiation reparative regeneration, thus restoring the disordered endocrine homeostasis in the pancreas.

Topics: Aging, Premature; Animals; Disease Models, Animal; Injections, Intraperitoneal; Male; Microcirculation; Microvessels; Oligopeptides; Pancreas; Pancreatic Hormones; Radiation Injuries, Experimental; Rats; Rats, Wistar