lysyl-glutamyl-aspartic-acid and Atherosclerosis

Atherosclerosis is a leading cause of obliterating diseases of the arteries in 80-90% of cases. The main pathogenetic mechanism is endothelial dysfunction, leading to hypertension, diabetes, congestive heart failure. The desire of modern society to improve the quality of life increases interest of human health in general and sexual health in particular, because the erectile function is an important factor in the quality of life, which makes us look for more effective methods of diagnosis, treatment and rehabilitation. The objective of the study was to assess the effectiveness of vasoactive tripeptide Vezugen in patients with vasculogenic erectile dysfunction as manifestation of atherosclerosis. Treatment results of erectile dysfunction in 41 patients were studied. A comparative analysis of clinical and instrumental parameters of blood flow in the main penile arteries before and after monotherapy was undertaken. The results show that the blood flow through the main artery of the penis after Vezugen treatment significantly improved both clinical and by objective indicators.

Topics: Aged; Aged, 80 and over; Arteries; Atherosclerosis; Drug Monitoring; Endothelial Cells; Erectile Dysfunction; Humans; Impotence, Vasculogenic; Male; Middle Aged; Oligopeptides; Penis; Protective Agents; Quality of Life; Treatment Outcome; Ultrasonography, Doppler, Duplex

Peptide KED (Lys-Glu-Asp) has vasoprotective effects and is effective substance in treatment of of atherosclerosis and other cardio-vascular disorders in elderly people. One of the probable mechanisms of biological activity of this peptide is epigenetic genes regulation. These genes can coding proteins, which are markers of endothelium functional activity. The goal of investigation was to study the KED peptide effect on signal molecules expression in normal, atherosclerotic and restenotic endothelium in vitro. It was shown, that KED peptide has normalized endothelin-1 expression, which increased during atherosclerosis and restenosis. KED peptide also restorates cells interactions by connexin expression. Geroprotective effect of KED peptide is realized by increasing of sirtuin1 expression, which has took part in DNA reparation.. Пептид KED (Lys-Glu-Asp) обладает выраженными вазопротекторными свойствами и является эффективным средством в терапии атеросклероза и другой патологии сердечно-сосудистой системы у людей пожилого возраста. Одним из возможных механизмов действия пептида KED является эпигенетическая регуляция экспрессии генов, кодирующих белки-маркеры функциональной активности эндотелия. Целью работы явилось изучение влияния пептида KED на экспрессию сигнальных молекул в эндотелии сосудов in vitro в норме, при атеросклерозе и рестенозе. Установлено, что пептид KED нормализует повышенную при атеросклерозе экспрессию эндотелина-1 и восстанавливает межклеточные взаимодействия эндотелиоцитов, осуществляемые коннексинами. Геропротекторное влияние пептида KED на эндотелий реализуется в повышении экспрессии сиртуина-1, белка, участвующего в репарации ДНК.

Topics: Aorta; Atherosclerosis; Endothelin-1; Endothelium, Vascular; Epigenesis, Genetic; Gene Expression Regulation; Humans; Oligopeptides; Pharmacogenetics; Protective Agents

We studied molecular mechanisms of the vasoprotective effects of tripeptide T-38 and dipeptide RR-1. Short peptides T-38 and the RR-1 activate the processes of cell renewal in organotypic and dissociated cultures of vascular cells during aging by increasing the expression of Ki-67 and reducing the synthesis of p53 protein. T-38 and RR-1 reduce the synthesis of E-selectin, adhesion molecule involved in the formation of atherosclerotic plaques.

Topics: Animals; Atherosclerosis; Cells, Cultured; Dipeptides; Drug Evaluation, Preclinical; Intracellular Signaling Peptides and Proteins; Oligopeptides; Plaque, Atherosclerotic; Rats, Wistar