lysophosphatidic acid has been researched along with Neoplasms in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 18 (25.00) | 29.6817 |
| 2010's | 37 (51.39) | 24.3611 |
| 2020's | 17 (23.61) | 2.80 |
| Authors | Studies |
|---|---|
| Borst, J; de Kivit, S; Frijlink, E; Haanen, J; Johnson, Z; Koster, J; Lança, T; Matas-Rico, E; Mazzocca, A; Menegakis, A; Moolenaar, WH; Morris, AJ; Perrakis, A; Salgado-Polo, F; Schumacher, TN; van den Berg, JH; van der Haar Àvila, I; van Zon, M; Verbrugge, I | 1 |
| Aoki, J; Hla, T; Kano, K | 1 |
| Arya, N; Kumar, A; Vishwakarma, S | 1 |
| Buser, A; Jacobelli, J; Kremer, KN; Narumiya, S; Pelanda, R; Thumkeo, D; Torres, RM | 1 |
| Aidinis, V; Kaffe, E; Magkrioti, C | 1 |
| Ahmadi, S; Lotay, N; Thompson, M | 1 |
| Amano, Y; Hara, K; Takai, M; Takamoto, M; Tsujiuchi, T; Yamamoto, M; Yashiro, N | 1 |
| Cvrtila, A; Dragojević, S; Jelić, D; Kraljić, K; Mesić, M; Sinković, V; Žiher, D | 1 |
| Benesch, MGK; Brindley, DN; Tang, X | 1 |
| Eisenberg, L; Eisenberg-Bord, M; Eisenberg-Lerner, A; Sagi-Eisenberg, R | 1 |
| Brindley, DN; Hemmings, DG | 1 |
| Brindley, DN; Tang, X | 1 |
| Balázs, L; Balogh, A; Bavaria, M; Benyó, Z; Kuo, B; Lee, SC; Lin, KH; Norman, DD; Tigyi, G; Yue, J | 1 |
| Mathew, D; Torres, RM | 1 |
| Jang, IH; Lee, SC; Lin, KH; Tigyi, G | 1 |
| Ferreira, BO; Gamarra, LF; Marti, L; Nucci, MP; Oliveira, FA; Rego, GNA | 1 |
| Aiello, S; Casiraghi, F | 1 |
| Balijepalli, P; Meier, KE; Sitton, CC | 1 |
| Ben-Mrad, M; El Meddeb Hamrouni, A; Espenel, S; Guy, JB; Langrand-Escure, J; Magné, N; Rancoule, C; Rehailia-Blanchard, A; Trone, JC; Vallard, A; Xia, Y | 1 |
| Kokotos, G; Kokotou, MG; Limnios, D; Nikolaou, A; Psarra, A | 1 |
| Ando, K; Eino, D; Fukuhara, S; Iba, T; Ishii, S; Kidoya, H; Kishima, H; Mochizuki, N; Muramatsu, F; Naito, H; Takakura, N; Takara, K; Tsukada, Y; Wakabayashi, T; Yasuda, D | 1 |
| Ray, U; Roy, SS | 1 |
| Benesch, MGK; Brindley, DN; Meng, G; Tang, X; Yang, Z | 1 |
| González-Arenas, A; Valdés-Rives, SA | 1 |
| Li, D; Li, J; Lin, C; Song, G | 1 |
| Houssin, A; Leblanc, R; Peyruchaud, O | 1 |
| Kim, JH; Lee, D; Lee, SC; Suh, DS; Tigyi, GJ | 1 |
| Hisano, Y; Hla, T | 1 |
| Balazs, L; Balogh, A; Lee, SC; Norman, DD; Szabo, E; Tigyi, GJ; Yue, J; Zhao, G | 1 |
| Butt, E; Grunewald, TG; Willier, S | 1 |
| Buffa, J; DiDonato, JA; Finke, J; Fisher, EA; Hatala, D; Hazen, SL; Klipfell, E; Lindner, D; Parker, Y; Parsons-Wingerter, P; Rayman, P; Smith, JD; Tallant, TC; Wang, Z; Yusufishaq, MSS; Zamanian-Daryoush, M | 1 |
| Araki, M; Dong, Y; Fukushima, N; Hirane, M; Tsujiuchi, T | 1 |
| Dong, Y; Fukushima, N; Hirane, M; Tsujiuchi, T | 1 |
| Parrill, AL | 1 |
| Cecerska-Heryć, E; Dołęgowska, B; Jesionowska, A; Marczuk, N; Safranow, K | 1 |
| Boyd, S; Cheasty, A; Farooq, M; Foxton, C; Gutierrez, IF; Hamilton, NM; Hitchin, JR; Jordan, A; Lejeune, A; MacDonald, E; Moolenaar, WH; Ovaa, H; Owen, P; Pang, L; Pritchard, M; Quesada, MJ; Raynham, T; Ryder, H; Shah, P; Skeete, J; Stockley, M; Stowell, A; Trivier, E; Turnbull, A | 1 |
| Dowling, MR; Rosethorne, EM; Sattikar, A | 1 |
| Bartoszek, A; Parchem, K | 1 |
| Chun, J; Mutoh, T | 1 |
| Jacobs, JJ; Lambooij, JP; Moolenaar, WH; Stortelers, C; Taghavi, P; Tanger, E; van Lohuizen, M; Verhoeven, E | 1 |
| Peyruchaud, O | 1 |
| Boutin, JA; Ferry, G | 1 |
| Choi, JW; Chun, J; Herr, DR; Lee, CW; Lin, ME; Mosley, AN; Mutoh, T; Noguchi, K; Park, KE; Teo, ST; Yung, YC | 1 |
| Braddock, DT | 1 |
| Diamandis, EP | 1 |
| Bekele, R; Brindley, DN; Capatos, D; Samadi, N; Sariahmetoglu, M; Venkatraman, G | 1 |
| Khan, MA; Li, J; Song, Y; Tania, M; Zhang, H | 1 |
| Fukushima, N; Hayashi, M; Honoki, K; Mori, T; Okabe, K; Teranishi, M; Tsujiuchi, T; Yamawaki, Y | 1 |
| Murakami, M; Sato, H; Taketomi, Y; Yamamoto, K | 1 |
| Balazs, L; Fells, J; Fujiwara, Y; Gotoh, M; Gupte, R; Kennel, S; Lee, S; Liu, J; Miller, DD; Murakami-Murofushi, K; Patil, R; Tigyi, GJ; Uchiyama, A; Wall, J; Yue, J | 1 |
| Bae, SS; Ha, HK; Ha, JM; Jin, IH; Kim, EK; Kim, YW; Lee, HS; Woo, DH; Yun, SJ | 1 |
| Fu, XD; Guan, KL; Jewell, JL; Li, H; Lian, I; Mills, GB; Panupinthu, N; Tumaneng, K; Wang, LH; Yu, FX; Yuan, H; Zhao, B; Zhao, J | 1 |
| Do, EK; Heo, SC; Kim, JH; Kim, KH; Kim, YM; Kwon, YW; Shin, SH; Suh, DS; Yoon, MS | 1 |
| Brindley, DN; Lin, FT; Tigyi, GJ | 1 |
| Hengstler, JG; Lesjak, MS; Marchan, R; Seeliger, J; Stewart, JD; Winter, R | 1 |
| Fukushima, N; Honoki, K; Kitayoshi, M; Shibata, A; Tanabe, E; Tsujiuchi, T; Yoshikawa, K | 1 |
| Chazin, WJ; Chitayat, S; Li, Q; Pei, R; Rai, V; Ramasamy, R; Rosario, R; Schmidt, AM; Song, F; Touré, F; Zhang, J | 1 |
| Dong, Z; Korkina, O; Marullo, A; Ruggieri, R; Symons, M; Warshaw, G | 1 |
| Aoki, J; Arai, H; Chun, J; Fukaya, M; Hama, K; Kishi, Y; Ohta, H; Sakai, T; Suzuki, R; Watanabe, M; Yamori, T | 1 |
| Bandle, RW; Clair, T; Koh, E; Liotta, LA; Ptaszynska, M; Schiffmann, E; Stracke, ML | 1 |
| Christodoulou, E; Goding, JW; Kikuchi, K; Moolenaar, WH; Nagano, T; Perrakis, A; Ruurs, P; Takakusa, H; van Meeteren, LA | 1 |
| Malbon, CC | 1 |
| Chun, J; Dubin, AE; Gardell, SE | 1 |
| Alptürk, O; Crowe, WE; Escobedo, JO; Fakayode, SO; Král, V; Pruet, JM; Rusin, O; Strongin, RM; Wang, W; Warner, IM | 1 |
| Bae, GU; Chung, HC; Han, JW; Kim, BK; Kim, YK; Lee, EK; Lee, HY; Lee, J; Park, CG; Park, SY; Rha, SY | 1 |
| Liu, S; Mills, GB; Murph, M; Tanaka, T | 1 |
| Anthis, NJ; Davis, GE; Fisher, KE; Koh, W; Pop, A; Saunders, WB | 1 |
| Mills, GB; Murph, M | 1 |
| Fujiwara, Y; Gajewiak, J; Lu, Y; Mills, GB; Murph, M; Prestwich, GD; Tigyi, G; Tsukahara, R; Tsukahara, T; Yu, S | 1 |
| Brindley, DN; Hurst-Kennedy, J; Murph, MM; Newton, V; Radhakrishna, H | 1 |
| Chen, J; Fang, X; Gibson, SB; Graham, BA; Hu, X; Ishdorj, G; Johnston, JB | 1 |
| Gajewiak, J; Prestwich, GD; Serban, M; Xu, X; Yang, G; Zhang, H | 1 |
43 review(s) available for lysophosphatidic acid and Neoplasms
| Article | Year |
|---|---|
Lysophospholipid Mediators in Health and Disease.
Topics: Animals; Female; Fibrosis; Humans; Lysophospholipids; Neoplasms; Signal Transduction | 2022 |
Regulation of Tumor Immune Microenvironment by Sphingolipids and Lysophosphatidic Acid.
Topics: Humans; Lysophospholipids; Neoplasms; Signal Transduction; Sphingolipids; Tumor Microenvironment | 2022 |
Role of the autotaxin-lysophosphatidate axis in the development of resistance to cancer therapy.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Lysophospholipids; Neoplasms; Phosphoric Diester Hydrolases; Signal Transduction | 2020 |
Metabolic alterations in the tumor microenvironment and their role in oncogenesis.
Topics: Adenosine; Adipocytes; Cancer-Associated Fibroblasts; Carcinogenesis; Glycolysis; Humans; Lysophospholipids; Neoplasms; Signal Transduction; Tumor Microenvironment | 2020 |
Signalling by lysophosphatidate and its health implications.
Topics: Animals; Cardiovascular Diseases; Female; Humans; Idiopathic Pulmonary Fibrosis; Inflammation; Lysophospholipids; Neoplasms; Phosphatidate Phosphatase; Phosphoric Diester Hydrolases; Pregnancy; Pregnancy Complications; Receptors, G-Protein-Coupled; Signal Transduction; Wound Healing | 2020 |
Lipid Phosphate Phosphatases and Cancer.
Topics: Animals; Cell Membrane; Humans; Lysophospholipids; Neoplasms; Phosphatidate Phosphatase; Signal Transduction; Sphingosine; Up-Regulation | 2020 |
Dysregulation of lysophospholipid signaling by p53 in malignant cells and the tumor microenvironment.
Topics: Humans; Lysophospholipids; Neoplasms; Signal Transduction; Tumor Microenvironment; Tumor Suppressor Protein p53 | 2021 |
Lysophosphatidic Acid Is an Inflammatory Lipid Exploited by Cancers for Immune Evasion
Topics: Animals; CD8-Positive T-Lymphocytes; CTLA-4 Antigen; Humans; Inflammation; Lysophospholipids; Neoplasm Proteins; Neoplasms; Programmed Cell Death 1 Receptor; Receptors, Lysophosphatidic Acid; Signal Transduction; Tumor Escape | 2020 |
Revisiting the role of lysophosphatidic acid in stem cell biology.
Topics: Animals; Cell Differentiation; Cell Proliferation; Humans; Lysophospholipids; Neoplasms; Neoplastic Stem Cells | 2021 |
LN-Derived Fibroblastic Reticular Cells and Their Impact on T Cell Response-A Systematic Review.
Topics: Animals; Autoimmunity; Cell Proliferation; Cytokines; Fibroblasts; Homeostasis; Humans; Immunophenotyping; Lymph; Lymph Nodes; Lymphatic Vessels; Lymphocytes; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Neoplasms; Reticulin; T-Lymphocytes | 2021 |
Lysophosphatidic Acid: Promoter of Cancer Progression and of Tumor Microenvironment Development. A Promising Target for Anticancer Therapies?
Topics: Humans; Lysophospholipids; Neoplasm Proteins; Neoplasms; Phosphoric Diester Hydrolases; Signal Transduction; Tumor Microenvironment | 2021 |
Lysophosphatidic Acid Signaling in Cancer Cells: What Makes LPA So Special?
Topics: Arrestins; Cell Movement; Cell Proliferation; Humans; Lysophospholipids; Models, Molecular; Neoplasms; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Signal Transduction | 2021 |
Lysophosphatidic acid (LPA) as a pro-fibrotic and pro-oncogenic factor: a pivotal target to improve the radiotherapy therapeutic index.
Topics: Animals; Biomarkers; Cell Transformation, Neoplastic; Fibrosis; Humans; Lysophospholipids; Neoplasms; Radiation Tolerance; Radiation, Ionizing; Radiotherapy; Signal Transduction; Therapeutic Index | 2017 |
Autotaxin inhibitors: a patent review (2012-2016).
Topics: Animals; Antineoplastic Agents; Drug Design; Humans; Idiopathic Pulmonary Fibrosis; Lysophospholipids; Neoplasms; Patents as Topic; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases | 2017 |
Aberrant lipid metabolism in cancer cells - the role of oncolipid-activated signaling.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drugs, Investigational; Fatty Acid Synthase, Type I; Gene Expression Regulation, Neoplastic; Humans; Lipid Metabolism; Lipids; Lipogenesis; Lysophospholipids; Models, Biological; Molecular Targeted Therapy; Neoplasm Proteins; Neoplasms; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid; Signal Transduction; Stearoyl-CoA Desaturase; Sterol Regulatory Element Binding Protein 1 | 2018 |
Lysophosphatidate Signaling: The Tumor Microenvironment's New Nemesis.
Topics: Drug Resistance, Neoplasm; Humans; Inflammation; Lysophospholipids; Multienzyme Complexes; Mutation; Neoplasms; Phosphodiesterase I; Signal Transduction; Tumor Microenvironment | 2017 |
Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development.
Topics: Humans; Inflammation; Lysophospholipids; Neoplasms; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid; Signal Transduction | 2017 |
[Effect of Lysophosphatidic Acid on Cell Migration and Its Relative Molecular Mechanisms].
Topics: Cell Line, Tumor; Cell Movement; Humans; Lysophospholipids; Neoplasms; Receptors, Lysophosphatidic Acid; Signal Transduction; Stem Cells | 2016 |
Platelets, autotaxin and lysophosphatidic acid signalling: win-win factors for cancer metastasis.
Topics: Animals; Blood Platelets; Humans; Lysophospholipids; Megakaryocytes; Neoplasm Metastasis; Neoplasms; Phosphoric Diester Hydrolases; Signal Transduction | 2018 |
Role of autotaxin in cancer stem cells.
Topics: Animals; Humans; Lysophospholipids; Neoplasms; Neoplastic Stem Cells; Phosphoric Diester Hydrolases | 2018 |
Bioactive lysolipids in cancer and angiogenesis.
Topics: Animals; Cell Movement; Humans; Lysophospholipids; Neoplasms; Neovascularization, Pathologic; Sphingosine | 2019 |
Regulation of tumor cell - Microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis.
Topics: Animals; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Humans; Lysophospholipids; Neoplasm Proteins; Neoplasms; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid; Signal Transduction; Tumor Microenvironment | 2019 |
Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: a focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays.
Topics: Animals; Cell Movement; Humans; Lysophospholipids; Neoplasm Invasiveness; Neoplasms; Oligonucleotide Array Sequence Analysis; Receptors, Lysophosphatidic Acid; Signal Transduction | 2013 |
Lysophosphatidic acid receptors in cancer pathobiology.
Topics: Animals; Humans; Lysophospholipids; Neoplasms; Receptors, Lysophosphatidic Acid; Signal Transduction | 2014 |
Diverse effects of LPA receptors on cell motile activities of cancer cells.
Topics: Animals; Cell Movement; Humans; Lysophospholipids; Models, Biological; Neoplasm Invasiveness; Neoplasms; Receptors, Lysophosphatidic Acid; Signal Transduction | 2014 |
Design of anticancer lysophosphatidic acid agonists and antagonists.
Topics: Antineoplastic Agents; Humans; Lysophospholipids; Neoplasms; Receptors, Lysophosphatidic Acid; Signal Transduction; Structure-Activity Relationship | 2014 |
[Lysophosphatidic acid and malignant neoplasms].
Topics: Cell Movement; Cell Proliferation; Humans; Lysophospholipids; Neoplasms; Receptors, Lysophosphatidic Acid; Signal Transduction | 2015 |
Phospholipids and products of their hydrolysis as dietary preventive factors for civilization diseases.
Topics: Autoimmune Diseases; Ceramides; Fatty Acids; Female; Food; Humans; Hydrolysis; Lysophospholipids; Male; Neoplasms; Nervous System Diseases; Phospholipids | 2016 |
Lysophospholipid activation of G protein-coupled receptors.
Topics: Animals; Asthma; Autoimmune Diseases; Cardiovascular Diseases; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Survival; Gap Junctions; Humans; Immunologic Factors; Lysophospholipids; Neoplasms; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2008 |
Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer.
Topics: Fingolimod Hydrochloride; Humans; Lysophospholipids; Neoplasms; Propylene Glycols; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Sphingosine | 2009 |
Autotaxin.
Topics: Enzyme Inhibitors; Humans; Lysophospholipids; Multienzyme Complexes; Neoplasm Metastasis; Neoplasms; Obesity; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases | 2009 |
LPA receptors: subtypes and biological actions.
Topics: Animals; Cardiovascular Physiological Phenomena; Fibrosis; Humans; Immune System; Lysophospholipids; Neoplasms; Nervous System Physiological Phenomena; Obesity; Receptors, Lysophosphatidic Acid; Reproduction; Signal Transduction | 2010 |
Autotaxin and lipid signaling pathways as anticancer targets.
Topics: Animals; Humans; Lysophospholipids; Molecular Targeted Therapy; Multienzyme Complexes; Neoplasms; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Signal Transduction | 2010 |
Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance.
Topics: Animals; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Male; Mice; Multienzyme Complexes; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Phosphatidate Phosphatase; Phosphodiesterase I; Phospholipase D; Phosphoric Diester Hydrolases; Pyrophosphatases; Signal Transduction; Sphingosine | 2011 |
Autotaxin: a protein with two faces.
Topics: Catalysis; Humans; Lipid Metabolism; Lysophospholipids; Multienzyme Complexes; Neoplasms; Phosphatidic Acids; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases | 2010 |
Secreted phospholipase A2 revisited.
Topics: Animals; Arthritis; Catalysis; Glycerophospholipids; Group II Phospholipases A2; Heart Injuries; Humans; Inflammation; Lysophospholipids; Metabolic Syndrome; Mice; Neoplasms; Phospholipases A2; Phospholipids; Respiratory Distress Syndrome; Signal Transduction | 2011 |
Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis.
Topics: Animals; Antineoplastic Agents; Humans; Lysophospholipids; Molecular Targeted Therapy; Neoplasm Invasiveness; Neoplasms; Organophosphonates; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid; Signal Transduction; Xenograft Model Antitumor Assays | 2012 |
Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy.
Topics: Animals; Drug Resistance, Neoplasm; Humans; Lysophospholipids; Neoplasms; Phosphoric Diester Hydrolases; Radiation Tolerance; Receptors, Lysophosphatidic Acid; Signal Transduction | 2013 |
Beta-catenin, cancer, and G proteins: not just for frizzleds anymore.
Topics: Animals; beta Catenin; Cell Line, Tumor; Colonic Neoplasms; Frizzled Receptors; Heterotrimeric GTP-Binding Proteins; Humans; Invertebrates; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lymphoid Enhancer-Binding Factor 1; Lysophospholipids; Models, Biological; Neoplasm Proteins; Neoplasms; Phospholipase C beta; Protein Kinase C; Receptors, Lysophosphatidic Acid; Signal Transduction; Type C Phospholipases; Vertebrates; Wnt Proteins | 2005 |
Emerging medicinal roles for lysophospholipid signaling.
Topics: Animals; Autoimmune Diseases; Cardiovascular Diseases; Humans; Lysophospholipids; Neoplasms; Obesity; Phosphorylation; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Transplantation Immunology | 2006 |
Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer.
Topics: Animals; Drug Delivery Systems; Humans; Lysophospholipids; Metabolic Networks and Pathways; Models, Biological; Neoplasms; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Sphingosine | 2006 |
Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression.
Topics: Disease Progression; Drug Delivery Systems; Lysophospholipids; Neoplasms; Signal Transduction; Sphingosine; Treatment Outcome | 2007 |
Phosphatase-resistant analogues of lysophosphatidic acid: agonists promote healing, antagonists and autotaxin inhibitors treat cancer.
Topics: Animals; Enzyme Inhibitors; Humans; Lysophospholipids; Neoplasms; Phosphoric Monoester Hydrolases; Pyrophosphatases; Wound Healing | 2008 |
29 other study(ies) available for lysophosphatidic acid and Neoplasms
| Article | Year |
|---|---|
Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8
Topics: Animals; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Chemotaxis; Female; Humans; Lymphocytes, Tumor-Infiltrating; Lysophospholipids; Mice; Mice, Inbred C57BL; Neoplasms; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid; Signal Transduction; Tumor Microenvironment | 2021 |
LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation.
Topics: Animals; CD8-Positive T-Lymphocytes; Cytoskeleton; Humans; Immunological Synapses; Infections; Inositol 1,4,5-Trisphosphate Receptors; Lysophospholipids; Mice; Neoplasms; Receptors, Lysophosphatidic Acid | 2022 |
The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer.
Topics: Embryonic Development; Humans; Lysophospholipids; Neoplasms; Phosphoric Diester Hydrolases | 2023 |
Affinity-based electrochemical biosensor with antifouling properties for detection of lysophosphatidic acid, a promising early-stage ovarian cancer biomarker.
Topics: Biofouling; Biomarkers, Tumor; Biosensing Techniques; Electrochemical Techniques; Electrodes; Humans; Lysophospholipids; Neoplasms | 2023 |
Induction of lysophosphatidic acid (LPA) receptor-mediated signaling regulates cell motility and survival to anticancer drugs in cancer cells treated with hydrogen peroxide.
Topics: Antineoplastic Agents; Cell Movement; Fluorouracil; Humans; Hydrogen Peroxide; Neoplasms; Receptors, Lysophosphatidic Acid | 2023 |
Benzoxaboroles-Novel Autotaxin Inhibitors.
Topics: Animals; Humans; Lysophosphatidylcholines; Lysophospholipids; Neoplasms; Phosphoric Diester Hydrolases; Rats; Structure-Activity Relationship | 2019 |
Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact.
Topics: Animals; Antigens, CD; Cadherins; Cell Communication; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Drug Delivery Systems; Endothelial Cells; Lysophospholipids; Mice; Neoplasms; Neovascularization, Pathologic; Receptors, Lysophosphatidic Acid; Signal Transduction | 2017 |
The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.
Topics: Animals; Antigen Presentation; Antineoplastic Agents; Apolipoprotein A-I; Apolipoprotein A-II; Carcinogenesis; Cardiotonic Agents; Cell Line, Tumor; Cell Proliferation; Dendritic Cells; Female; Humans; Immunity; Immunocompetence; Lipoproteins, HDL; Lysophospholipids; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Remission Induction; Survival Analysis; Tumor Microenvironment | 2013 |
Discovery of potent inhibitors of the lysophospholipase autotaxin.
Topics: Animals; Antineoplastic Agents; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Lysophospholipase; Lysophospholipids; Mice; Molecular Docking Simulation; Molecular Targeted Therapy; Neoplasms; Phosphoric Diester Hydrolases; Pyridines | 2016 |
Endogenous lysophosphatidic acid (LPA
Topics: Calcium; Cells, Cultured; Fibroblasts; Fibrosis; Humans; Ligands; Lung; Lysophospholipids; MAP Kinase Signaling System; Neoplasms; Receptors, Lysophosphatidic Acid; Signal Transduction | 2017 |
In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation.
Topics: Animals; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p16; Embryo, Mammalian; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Gene Expression Regulation, Neoplastic; Genes, myc; Genetic Testing; Humans; Lysophospholipids; Mice; Neoplasms; Receptors, Lysophosphatidic Acid | 2008 |
Cancer biomarkers: can we turn recent failures into success?
Topics: Animals; Antigens, Neoplasm; Biomarkers, Tumor; CA-125 Antigen; Clinical Trials as Topic; Female; Humans; Lysophospholipids; Male; Mass Screening; Mass Spectrometry; Neoplasms; Nuclear Magnetic Resonance, Biomolecular; Osteopontin; Ovarian Neoplasms; Predictive Value of Tests; Prognosis; Prostatic Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Validation Studies as Topic | 2010 |
Possible involvement of lysophosphatidic acid receptor-5 gene in the acquisition of growth advantage of rat tumor cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; DNA Methylation; Gene Expression Regulation, Neoplastic; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Lysophospholipids; Mutation; Neoplasms; Rats; Receptors, Lysophosphatidic Acid | 2011 |
Synergistic induction of cancer cell migration regulated by Gβγ and phosphatidylinositol 3-kinase.
Topics: Cell Line, Tumor; Cell Movement; Enzyme Activation; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Guanine Nucleotide Exchange Factors; Humans; Lysophospholipids; Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptors, G-Protein-Coupled; Signal Transduction | 2012 |
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.
Topics: Acyltransferases; Animals; Cell Cycle Proteins; Cell Line; Cell Movement; Cell Proliferation; Humans; Lysophospholipids; Neoplasms; Nuclear Proteins; Organ Size; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, G-Protein-Coupled; Serum; Signal Transduction; Sphingosine; Transcription Factors | 2012 |
Lysophosphatidic acid-induced ADAM12 expression mediates human adipose tissue-derived mesenchymal stem cell-stimulated tumor growth.
Topics: Actins; ADAM Proteins; ADAM12 Protein; Adenocarcinoma; Adenocarcinoma of Lung; Adipose Tissue; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Culture Media, Conditioned; Extracellular Matrix Proteins; Fibroblasts; Gene Silencing; Humans; Lung Neoplasms; Lysophospholipids; Membrane Proteins; Mesenchymal Stem Cells; Mice; Mice, Nude; Neoplasms; Receptors, Lysophosphatidic Acid; RNA, Small Interfering; Transforming Growth Factor beta; Xenograft Model Antitumor Assays | 2012 |
Choline-releasing glycerophosphodiesterase EDI3 links the tumor metabolome to signaling network activities.
Topics: Animals; Choline; Diglycerides; Humans; Lysophospholipids; Models, Biological; Neoplasms; Phosphatidic Acids; Phosphoric Diester Hydrolases; Signal Transduction | 2012 |
Loss of lysophosphatidic acid receptor-3 suppresses cell migration activity of human sarcoma cells.
Topics: Cell Line, Tumor; Cell Movement; Humans; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasms; Receptors, Lysophosphatidic Acid; Sarcoma; Signal Transduction | 2012 |
Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling.
Topics: Animals; Cell Line, Tumor; Cyclin D1; Female; Humans; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Muscle, Smooth, Vascular; Neoplasms; Proto-Oncogene Proteins c-akt; Rats; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Recombinant Proteins; Signal Transduction | 2012 |
The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion.
Topics: Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Laminin; Lysophospholipids; Models, Biological; Myosins; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proteoglycans; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; rhoC GTP-Binding Protein; Signal Transduction | 2013 |
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.
Topics: Animals; Calcium; Cell Line; Cell Line, Tumor; Cell Movement; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Fibroblasts; Glucose-6-Phosphate Isomerase; Glycoproteins; Isoxazoles; Lysophospholipids; Mice; Mice, Knockout; Mice, Transgenic; Microscopy, Fluorescence; Models, Biological; Multienzyme Complexes; Neoplasms; Phosphodiesterase I; Phosphoric Diester Hydrolases; Platelet-Derived Growth Factor; Propionates; Pyrophosphatases; rac1 GTP-Binding Protein; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; Signal Transduction; Skin; Time Factors | 2004 |
L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin.
Topics: Cations, Divalent; Cell Line, Tumor; Cell Proliferation; Chelating Agents; Cytokines; Enzyme Activation; Histidine; Humans; Lysophospholipids; Molecular Structure; Multienzyme Complexes; Neoplasms; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Substrate Specificity; Zinc | 2005 |
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.
Topics: Allosteric Site; Binding Sites; Biosensing Techniques; Blotting, Western; Catalysis; Catalytic Domain; Cell Line; Cell Movement; DNA, Complementary; Dose-Response Relationship, Drug; Fluorescence Resonance Energy Transfer; Glucose-6-Phosphate Isomerase; Glycoproteins; Humans; Hydrolysis; Kinetics; Ligands; Lipid Metabolism; Lipids; Lysophosphatidylcholines; Lysophospholipids; Models, Chemical; Multienzyme Complexes; Mutagenesis; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Phosphodiesterase I; Phospholipase D; Phosphoric Diester Hydrolases; Pyrophosphatases; Recombinant Fusion Proteins; Recombinant Proteins; Sphingosine; Transfection | 2005 |
Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers.
Topics: Biomarkers, Tumor; Carbohydrate Sequence; Europium; Female; Fluorescent Dyes; Gangliosides; Humans; Hydrogen-Ion Concentration; Lanthanum; Lysophospholipids; Methanol; Molecular Sequence Data; Neoplasms; Ovarian Neoplasms; Salicylates | 2006 |
Activation of hypoxia-inducible factor-1alpha is necessary for lysophosphatidic acid-induced vascular endothelial growth factor expression.
Topics: Blotting, Western; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoprecipitation; Lysophospholipids; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Transfection; Vascular Endothelial Growth Factor A | 2006 |
Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling.
Topics: cdc42 GTP-Binding Protein; Cell Movement; Collagen; Extracellular Matrix; GTP-Binding Proteins; Humans; Lipids; Lysophospholipids; Matrix Metalloproteinase 14; Matrix Metalloproteinases; Models, Biological; Neoplasm Invasiveness; Neoplasms; rac1 GTP-Binding Protein; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; RNA, Small Interfering; Signal Transduction; Sphingosine; Time Factors; Tumor Cells, Cultured | 2006 |
Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor.
Topics: Cell Line, Tumor; Humans; Lysophospholipids; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Neoplasms; Organophosphonates; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2007 |
Lysophosphatidic acid decreases the nuclear localization and cellular abundance of the p53 tumor suppressor in A549 lung carcinoma cells.
Topics: Apoptosis; Carcinoma; Cell Line, Tumor; Cell Nucleus; DNA Damage; Humans; Lung Neoplasms; Lysophospholipids; Mitogens; Neoplasms; Receptors, Lysophosphatidic Acid; Transcription, Genetic; Tumor Suppressor Protein p53 | 2007 |
Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC.
Topics: Apoptosis; Catalysis; Cell Membrane; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Isoxazoles; Lymphocytes; Lysophospholipids; Models, Biological; Neoplasms; Permeability; Promoter Regions, Genetic; Propionates; Repressor Proteins | 2008 |