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lysophosphatidic acid and Neoplasm Metastasis

lysophosphatidic acid has been researched along with Neoplasm Metastasis in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's14 (32.56)29.6817
2010's26 (60.47)24.3611
2020's3 (6.98)2.80

Authors

AuthorsStudies
Brindley, DN; Hemmings, DG; McMullen, TPW; Tang, X; Yang, Z1
Damirin, A; Li, A; Li, R; Sun, H; Wang, Y; Yan, Y; Yun, Q; Zhao, P1
Cutiongco, MFA; Fort, L; Gadegaard, N; Insall, RH; Juin, A; Kalna, G; Koh, YWH; Lilla, S; Machesky, LM; Mackay, G; Martin, KJ; McGhee, E; Neilson, M; Norman, JC; Spence, HJ; Thomason, P1
Jangde, N; Rai, V; Ray, R; Singh, SK; Sinha, S1
Contursi, A; Dovizio, M; Grande, R; Patrignani, P; Sacco, A1
Houssin, A; Leblanc, R; Peyruchaud, O1
Chryplewicz, A; Eckert, MA; Lengyel, E; Nahotko, DA; Peters, PN; Tienda, SM1
Herrera, M; Losert, W; Parent, CA; Sato, M; Shou, K; Stuelten, CH; Vedham, V; Weiger, MC1
Buffa, J; DiDonato, JA; Finke, J; Fisher, EA; Hatala, D; Hazen, SL; Klipfell, E; Lindner, D; Parker, Y; Parsons-Wingerter, P; Rayman, P; Smith, JD; Tallant, TC; Wang, Z; Yusufishaq, MSS; Zamanian-Daryoush, M1
Huang, YL; Lan, SY; Lee, H; Lin, YC; Wu, PY1
Araki, M; Dong, Y; Fukushima, N; Hirane, M; Kitayoshi, M; Tanabe, E; Tsujiuchi, T1
Abdel-Latif, A; Morris, AJ; Ratajczak, MZ; Schneider, G; Sellers, ZP1
Benesch, MG; Brindley, DN; Curtis, JM; Dewald, J; McMullen, TP; Patwardhan, N; Santos, WL; Tang, X; Zhao, YY1
Bennett, DC; Faller, WJ; Herd, R; Insall, RH; Jones, R; Kalna, G; Knecht, DA; Lindsay, C; Machesky, LM; Muinonen-Martin, AJ; Sansom, OJ; Smethurst, E; Susanto, O; Veltman, DM; Wakelam, MJ; Zhang, Q1
Ambatipudi, S; Clézardin, P; Grunewald, TG; Leblanc, R; Peyruchaud, O; Ribeiro, J; Sahay, D1
Bhuwania, R; Failla, AV; Gromova, K; Izbicki, JR; Kneussel, M; Lange, T; Lin, YN; Linder, S; Riecken, K; Windhorst, S1
Cai, Q; Fan, Q; Xu, Y1
Furukawa, S; Handa, H; Hashimoto, A; Hashimoto, S; Mikami, S; Oikawa, T; Okada, Y; Onodera, Y; Oya, M; Sabe, H; Sugino, H; Yoshikawa, A1
Boutin, JA; Ferry, G1
Kirmani, K; Li, H; Steinmetz, R; Wang, D; Xu, Y; Zhang, H; Zhao, Z1
Fishman, DA; Wang, F1
Collins, J; Marino, N; Marshall, JC; Steeg, P1
Aoki, J; Bendriss-Vermare, N; Bollen, M; Clézardin, P; David, M; Descotes, F; Deux, B; Grès, S; Jansen, S; Peyruchaud, O; Ribeiro, J; Saez, S; Saulnier-Blache, JS; Serre, CM; Wannecq, E1
Bekele, R; Brindley, DN; Capatos, D; Samadi, N; Sariahmetoglu, M; Venkatraman, G1
Chen, H; Huang, S; Pan, ZK; Wu, X1
Du, J; Gu, L; Hu, Z; Lu, X; Sun, C; Yang, Y; Zheng, D; Zhu, Y1
Choi, JW; Kim, EK; Kim, HS; Kim, KT; Lee, DS; Lim, S; Oh, K; Park, JM; Ryu, SH; Seo, JK; Seok, H; Suh, PG1
Goldsmith, PK; Heger, CD; Kelly, K; Lake, R; Merino, M; Raffeld, M; Ward, Y; Yin, JJ1
Im, DS; Ishii, S; Kimura, T; Komachi, M; Mogi, C; Ohta, H; Okajima, F; Sato, K; Takeyoshi, I; Tobo, M; Tomura, H; Yamada, T; Yanagida, K1
Chou, LY; Huang, RY; Liao, CK; Wang, SH; Wen, CC; Wu, JC1
Boyon, C; D'Anjou, F; Day, R; Desmons, A; Farré, I; Fournier, I; Leblanc, E; Longuespée, R; Ly, K; Salzet, M; Vinatier, D; Wisztorski, M1
Dong, Z; Korkina, O; Marullo, A; Ruggieri, R; Symons, M; Warshaw, G1
Gupta, GP; Massagué, J1
Bordet, JC; Boucharaba, A; Clézardin, P; Grès, S; Guglielmi, J; Peyruchaud, O; Saulnier-Blache, JS; Serre, CM1
Fishman, DA; Kang, S; Meng, Y1
Kondo, M; Nishihira, J; Sasaki, F; Sato, Y; Sun, B; Todo, S; Yoshiki, T1
Christodoulou, E; Goding, JW; Kikuchi, K; Moolenaar, WH; Nagano, T; Perrakis, A; Ruurs, P; Takakusa, H; van Meeteren, LA1
Berk, M; Jiang, Y; Powell, CT; Singh, LS; Tan, H; Xu, Y; Yin, L1
Bordet, JC; Boucharaba, A; Clézardin, P; Guglielmi, J; Peyruchaud, O; Serre, CM1
Baker, DL; Bandle, RW; Bittman, R; Byun, HS; Fan, D; Fujiwara, Y; Kobayashi, S; Koh, E; Mills, GB; Murakami-Murofushi, K; Murofushi, H; Murph, M; Pigg, KR; Tigyi, G; Tsukahara, R; Uchiyama, A1
Belinson, J; Berk, M; Escobar, PF; Kim, KS; Kwak, YG; Mok, SC; Sengupta, S; Xu, Y1
Belinson, J; Berk, MP; Escobar, P; Kim, KS; Li, W; Lindner, DJ; Oates, R; Sengupta, S; Williams, B; Xu, Y1
Brinkmann, V; Lynch, KR; Moolenaar, WH; Saulnier-Blache, JS; van Meeteren, LA1

Reviews

8 review(s) available for lysophosphatidic acid and Neoplasm Metastasis

ArticleYear
Platelets as crucial partners for tumor metastasis: from mechanistic aspects to pharmacological targeting.
    Cellular and molecular life sciences : CMLS, 2017, Volume: 74, Issue:19

    Topics: Animals; Aspirin; Blood Platelets; Eicosanoids; Epithelial-Mesenchymal Transition; Humans; Lysophospholipids; Molecular Targeted Therapy; Neoplasm Metastasis; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Purinergic P2Y Receptor Antagonists; Receptors, Prostaglandin E, EP3 Subtype

2017
Platelets, autotaxin and lysophosphatidic acid signalling: win-win factors for cancer metastasis.
    British journal of pharmacology, 2018, Volume: 175, Issue:15

    Topics: Animals; Blood Platelets; Humans; Lysophospholipids; Megakaryocytes; Neoplasm Metastasis; Neoplasms; Phosphoric Diester Hydrolases; Signal Transduction

2018
Autotaxin.
    Cellular and molecular life sciences : CMLS, 2009, Volume: 66, Issue:18

    Topics: Enzyme Inhibitors; Humans; Lysophospholipids; Multienzyme Complexes; Neoplasm Metastasis; Neoplasms; Obesity; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases

2009
Lysophosphatidic acid and invasion.
    Cancer treatment and research, 2009, Volume: 149

    Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cyclooxygenase 2; Diterpenes; Female; Humans; Interleukins; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Membrane Lipids; Mice; Multienzyme Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; Ovarian Neoplasms; Peptide Hydrolases; Phosphodiesterase I; Phospholipases A; Phosphoric Diester Hydrolases; Pyrophosphatases; Receptors, Lysophosphatidic Acid; Signal Transduction; Sphingosine; Vascular Endothelial Growth Factor A

2009
The Nm23-H1 metastasis suppressor as a translational target.
    European journal of cancer (Oxford, England : 1990), 2010, Volume: 46, Issue:7

    Topics: Animals; Antineoplastic Agents; Genetic Therapy; Humans; Lysophospholipids; Medroxyprogesterone Acetate; Mice; Neoplasm Metastasis; NM23 Nucleoside Diphosphate Kinases; Translational Research, Biomedical

2010
Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance.
    Biochimie, 2011, Volume: 93, Issue:1

    Topics: Animals; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Male; Mice; Multienzyme Complexes; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Phosphatidate Phosphatase; Phosphodiesterase I; Phospholipase D; Phosphoric Diester Hydrolases; Pyrophosphatases; Signal Transduction; Sphingosine

2011
Ovarian cancer molecular pathology.
    Cancer metastasis reviews, 2012, Volume: 31, Issue:3-4

    Topics: Animals; CA-125 Antigen; Cell Proliferation; Female; Humans; I-kappa B Kinase; Lysophospholipids; MAP Kinase Signaling System; Neoplasm Metastasis; NF-kappa B; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Proteomics; Receptors, Estrogen; Signal Transduction

2012
Platelets and metastasis revisited: a novel fatty link.
    The Journal of clinical investigation, 2004, Volume: 114, Issue:12

    Topics: Blood Platelets; Bone and Bones; Breast Neoplasms; Cell Line, Tumor; Disease Progression; Female; Humans; Lysophospholipids; Models, Biological; Neoplasm Metastasis; Neovascularization, Pathologic; Osteolysis; Ovarian Neoplasms

2004

Other Studies

35 other study(ies) available for lysophosphatidic acid and Neoplasm Metastasis

ArticleYear
PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling.
    International journal of molecular sciences, 2021, Sep-10, Volume: 22, Issue:18

    Topics: Breast Neoplasms; Cytomegalovirus; Cytomegalovirus Infections; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; MCF-7 Cells; Neoplasm Metastasis; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction; Tumor Microenvironment; Virus Internalization

2021
LPA3 is a precise therapeutic target and potential biomarker for ovarian cancer.
    Medical oncology (Northwood, London, England), 2022, Jan-04, Volume: 39, Issue:2

    Topics: Animals; Biomarkers, Tumor; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Female; Gene Expression Regulation, Neoplastic; GTP-Binding Proteins; Humans; Immunohistochemistry; Lysophospholipids; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; Signal Transduction

2022
N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis.
    Developmental cell, 2019, 11-18, Volume: 51, Issue:4

    Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Chemotaxis; Female; Humans; Lysophospholipids; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Protein Transport; Rats; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein; Signal Transduction; Sorting Nexins; Wiskott-Aldrich Syndrome Protein, Neuronal

2019
Lysophosphatidic acid-RAGE axis promotes lung and mammary oncogenesis via protein kinase B and regulating tumor microenvironment.
    Cell communication and signaling : CCS, 2020, 10-27, Volume: 18, Issue:1

    Topics: Animals; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Gene Knockdown Techniques; Humans; Lung Neoplasms; Lymphocytes, Tumor-Infiltrating; Lysophospholipids; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Proto-Oncogene Proteins c-akt; Receptor for Advanced Glycation End Products; Signal Transduction; Tumor Microenvironment; Xenograft Model Antitumor Assays

2020
Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6.
    Scientific reports, 2019, 03-26, Volume: 9, Issue:1

    Topics: Animals; Cell Line, Tumor; Down-Regulation; Epithelial Cells; Fallopian Tubes; Female; HEK293 Cells; Humans; Lysophospholipids; Mice, Nude; Mutation; Neoplasm Metastasis; Phosphoric Monoester Hydrolases; Signal Transduction; Tumor Suppressor Protein p53

2019
Real-time motion analysis reveals cell directionality as an indicator of breast cancer progression.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Migration Assays; Cell Movement; Disease Progression; Epidermal Growth Factor; Female; Humans; Lysophospholipids; Neoplasm Metastasis; Phenotype; Tumor Stem Cell Assay

2013
The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.
    The Journal of biological chemistry, 2013, Jul-19, Volume: 288, Issue:29

    Topics: Animals; Antigen Presentation; Antineoplastic Agents; Apolipoprotein A-I; Apolipoprotein A-II; Carcinogenesis; Cardiotonic Agents; Cell Line, Tumor; Cell Proliferation; Dendritic Cells; Female; Humans; Immunity; Immunocompetence; Lipoproteins, HDL; Lysophospholipids; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Remission Induction; Survival Analysis; Tumor Microenvironment

2013
Aromatic hydrocarbon receptor inhibits lysophosphatidic acid-induced vascular endothelial growth factor-A expression in PC-3 prostate cancer cells.
    Biochemical and biophysical research communications, 2013, Aug-02, Volume: 437, Issue:3

    Topics: Angiogenesis Inducing Agents; Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Line, Tumor; HEK293 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Male; Neoplasm Metastasis; Neovascularization, Pathologic; Prostatic Neoplasms; Receptors, Aryl Hydrocarbon; Signal Transduction; Vascular Endothelial Growth Factor A

2013
Downregulation of activation factors of endothelia and fibroblasts via lysophosphatidic acid signaling in a mouse lung cancer LL/2 cell line.
    Journal of receptor and signal transduction research, 2013, Volume: 33, Issue:5

    Topics: 3T3 Cells; Animals; Cell Movement; Endothelial Cells; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lysophospholipids; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Neovascularization, Pathologic; Receptors, Lysophosphatidic Acid; Signal Transduction; Vascular Endothelial Growth Factor A

2013
Bioactive lipids, LPC and LPA, are novel prometastatic factors and their tissue levels increase in response to radio/chemotherapy.
    Molecular cancer research : MCR, 2014, Volume: 12, Issue:11

    Topics: Animals; Bone Marrow; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Chemotactic Factors; Drug Resistance, Neoplasm; Gamma Rays; Humans; Isoxazoles; Lysophosphatidylcholines; Lysophospholipids; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, SCID; Neoplasm Metastasis; Propionates; Receptors, G-Protein-Coupled; Rhabdomyosarcoma; Tumor Microenvironment; Vincristine

2014
Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice.
    Journal of lipid research, 2014, Volume: 55, Issue:11

    Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression; Humans; Lysophospholipids; Mice; Neoplasm Metastasis; Phosphatidate Phosphatase; Signal Transduction

2014
Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal.
    PLoS biology, 2014, Volume: 12, Issue:10

    Topics: Animals; Cell Movement; Chemotaxis; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Melanoma; Mice; Neoplasm Metastasis

2014
The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer.
    Oncotarget, 2015, Aug-21, Volume: 6, Issue:24

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Heterografts; Homeodomain Proteins; Humans; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Receptors, Lysophosphatidic Acid; Signal Transduction; Transcription Factors; Transfection; Zinc Finger E-box-Binding Homeobox 1

2015
Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion.
    Oncotarget, 2015, Jul-30, Volume: 6, Issue:21

    Topics: Actin Cytoskeleton; Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Cell Adhesion; Colonic Neoplasms; Formins; HCT116 Cells; HEK293 Cells; Humans; Integrin beta1; Lysophospholipids; Mice, SCID; Microscopy, Fluorescence; Microtubules; Neoplasm Metastasis; RNA Interference; Time-Lapse Imaging; Transplantation, Heterologous

2015
FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer.
    Oncotarget, 2015, Sep-29, Volume: 6, Issue:29

    Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cystadenocarcinoma, Serous; Disease Progression; Dose-Response Relationship, Drug; Female; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Phosphoproteins; RNA Interference; Signal Transduction; Transcription Factors; Transcription, Genetic; YAP-Signaling Proteins

2015
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
    Nature communications, 2016, Feb-08, Volume: 7

    Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Adult; Aged; Aged, 80 and over; Amides; Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Immunohistochemistry; Indoles; Isoxazoles; Kidney Neoplasms; Lysophospholipids; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Nerve Tissue Proteins; Propionates; Pyridines; Pyrroles; Receptors, Lysophosphatidic Acid; Signal Transduction; Sirolimus; Sunitinib; Triazoles

2016
Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice.
    Molecular cancer therapeutics, 2009, Volume: 8, Issue:6

    Topics: Animals; Arachidonate 15-Lipoxygenase; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooxygenase 1; Female; Group IV Phospholipases A2; Humans; Immunocompetence; Lysophospholipids; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Tumor Stem Cell Assay

2009
Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts.
    PloS one, 2010, Mar-17, Volume: 5, Issue:3

    Topics: Animals; Blood Platelets; Bone and Bones; Bone Neoplasms; Cell Proliferation; Humans; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Multienzyme Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Osteoclasts; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases

2010
Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis.
    Cancer research, 2010, Dec-01, Volume: 70, Issue:23

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Animals; Blotting, Western; Cell Line, Tumor; Cell Movement; Cytoskeletal Proteins; Female; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Mice, Nude; Middle Aged; Multiprotein Complexes; Neoplasm Metastasis; Neoplasm Staging; Neoplasms, Experimental; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; RNA Interference; SOS1 Protein; Transplantation, Heterologous; Young Adult

2010
Lysophosphatidic acid induces MDA-MB-231 breast cancer cells migration through activation of PI3K/PAK1/ERK signaling.
    PloS one, 2010, Dec-30, Volume: 5, Issue:12

    Topics: Acetylcysteine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Lysophospholipids; Neoplasm Metastasis; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; Signal Transduction

2010
Activation of AMP-activated protein kinase is essential for lysophosphatidic acid-induced cell migration in ovarian cancer cells.
    The Journal of biological chemistry, 2011, Jul-08, Volume: 286, Issue:27

    Topics: AMP-Activated Protein Kinases; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Line, Tumor; Cell Membrane; Cell Movement; Cytoskeleton; Enzyme Activation; Female; Humans; Lysophospholipids; Neoplasm Metastasis; Ovarian Neoplasms; Phospholipase C beta; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein

2011
LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.
    Cancer research, 2011, Dec-01, Volume: 71, Issue:23

    Topics: Antigens, CD; Cell Line, Tumor; Disease Progression; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits, G12-G13; Guanosine Triphosphate; Humans; Lysophospholipids; Male; Neoplasm Invasiveness; Neoplasm Metastasis; Prostatic Neoplasms; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein; Signal Transduction

2011
Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.
    Cancer science, 2012, Volume: 103, Issue:6

    Topics: Animals; Ascites; Cell Line, Tumor; Cell Movement; Humans; Isoxazoles; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Peritoneal Neoplasms; Propionates; Receptors, Lysophosphatidic Acid; Xenograft Model Antitumor Assays

2012
Lysophosphatidic acid modulates the association of PTP1B with N-cadherin/catenin complex in SKOV3 ovarian cancer cells.
    Cell biology international, 2012, Volume: 36, Issue:9

    Topics: Adherens Junctions; Cadherins; Catenins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Lysophospholipids; Multiprotein Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-fyn; RNA Interference; RNA, Small Interfering; Signal Transduction; src-Family Kinases

2012
The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion.
    The Journal of biological chemistry, 2013, Feb-22, Volume: 288, Issue:8

    Topics: Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Laminin; Lysophospholipids; Models, Biological; Myosins; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proteoglycans; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; rhoC GTP-Binding Protein; Signal Transduction

2013
Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer.
    The Journal of clinical investigation, 2004, Volume: 114, Issue:12

    Topics: Animals; Blood Platelets; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cricetinae; Culture Media; Cytokines; Disease Progression; Dose-Response Relationship, Drug; Doxycycline; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Interleukin-6; Interleukin-8; Ki-67 Antigen; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogens; Models, Biological; Neoplasm Metastasis; Osteoclasts; Osteolysis; Phospholipase D; Platelet Activation; Platelet Aggregation; Reverse Transcriptase Polymerase Chain Reaction; RNA; Time Factors; Transfection

2004
Lysophosphatidic acid stimulates fas ligand microvesicle release from ovarian cancer cells.
    Cancer immunology, immunotherapy : CII, 2005, Volume: 54, Issue:8

    Topics: Blotting, Western; Cytoskeleton; Enzyme-Linked Immunosorbent Assay; Fas Ligand Protein; Female; Flow Cytometry; Humans; Lysophospholipids; Membrane Glycoproteins; Microtubules; Neoplasm Metastasis; Ovarian Neoplasms; Tumor Cells, Cultured; Up-Regulation

2005
Macrophage migration inhibitory factor promotes tumor invasion and metastasis via the Rho-dependent pathway.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Feb-01, Volume: 11, Issue:3

    Topics: Animals; Blotting, Western; Cell Line, Tumor; Female; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Macrophage Migration-Inhibitory Factors; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Protein Serine-Threonine Kinases; rho GTP-Binding Proteins; rho-Associated Kinases; RNA Interference; RNA, Small Interfering; Signal Transduction

2005
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.
    The Journal of biological chemistry, 2005, Jun-03, Volume: 280, Issue:22

    Topics: Allosteric Site; Binding Sites; Biosensing Techniques; Blotting, Western; Catalysis; Catalytic Domain; Cell Line; Cell Movement; DNA, Complementary; Dose-Response Relationship, Drug; Fluorescence Resonance Energy Transfer; Glucose-6-Phosphate Isomerase; Glycoproteins; Humans; Hydrolysis; Kinetics; Ligands; Lipid Metabolism; Lipids; Lysophosphatidylcholines; Lysophospholipids; Models, Chemical; Multienzyme Complexes; Mutagenesis; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Phosphodiesterase I; Phospholipase D; Phosphoric Diester Hydrolases; Pyrophosphatases; Recombinant Fusion Proteins; Recombinant Proteins; Sphingosine; Transfection

2005
KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha.
    Clinical & experimental metastasis, 2005, Volume: 22, Issue:5

    Topics: Animals; Cell Movement; Cell Proliferation; Down-Regulation; Female; Humans; Kisspeptins; Lysophospholipids; Mice; Mice, Nude; Neoplasm Metastasis; Ovarian Neoplasms; Protein Kinase C-alpha; Proteins; Transplantation, Heterologous; Tumor Suppressor Proteins

2005
The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Jun-20, Volume: 103, Issue:25

    Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytokines; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Lysophospholipids; Mice; Neoplasm Metastasis; Osteoclasts; Propionates; Receptors, Lysophosphatidic Acid

2006
Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis.
    The Journal of biological chemistry, 2006, Aug-11, Volume: 281, Issue:32

    Topics: Antineoplastic Agents; Cell Line, Tumor; Culture Media, Conditioned; Humans; Lipid Metabolism; Lysophospholipids; Melanoma; Multienzyme Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphatidic Acids; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Recombinant Proteins; Spectrometry, Fluorescence

2006
Hypoxia enhances lysophosphatidic acid responsiveness in ovarian cancer cells and lysophosphatidic acid induces ovarian tumor metastasis in vivo.
    Cancer research, 2006, Aug-15, Volume: 66, Issue:16

    Topics: Cell Hypoxia; Cell Movement; Female; Humans; Lysophospholipids; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Tumor Cells, Cultured

2006
Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion.
    Oncogene, 2007, May-03, Volume: 26, Issue:20

    Topics: Animals; Cell Movement; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2007
Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.
    Cancer letters, 2008, Aug-08, Volume: 266, Issue:2

    Topics: Animals; Antineoplastic Agents; Female; Humans; Lysophospholipids; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Neoplasm Metastasis; Neovascularization, Pathologic; Organophosphates; Phosphodiesterase I; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrophosphatases; Sphingosine

2008