lysophosphatidic acid has been researched along with Neoplasm Metastasis in 43 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (32.56) | 29.6817 |
| 2010's | 26 (60.47) | 24.3611 |
| 2020's | 3 (6.98) | 2.80 |
| Authors | Studies |
|---|---|
| Brindley, DN; Hemmings, DG; McMullen, TPW; Tang, X; Yang, Z | 1 |
| Damirin, A; Li, A; Li, R; Sun, H; Wang, Y; Yan, Y; Yun, Q; Zhao, P | 1 |
| Cutiongco, MFA; Fort, L; Gadegaard, N; Insall, RH; Juin, A; Kalna, G; Koh, YWH; Lilla, S; Machesky, LM; Mackay, G; Martin, KJ; McGhee, E; Neilson, M; Norman, JC; Spence, HJ; Thomason, P | 1 |
| Jangde, N; Rai, V; Ray, R; Singh, SK; Sinha, S | 1 |
| Contursi, A; Dovizio, M; Grande, R; Patrignani, P; Sacco, A | 1 |
| Houssin, A; Leblanc, R; Peyruchaud, O | 1 |
| Chryplewicz, A; Eckert, MA; Lengyel, E; Nahotko, DA; Peters, PN; Tienda, SM | 1 |
| Herrera, M; Losert, W; Parent, CA; Sato, M; Shou, K; Stuelten, CH; Vedham, V; Weiger, MC | 1 |
| Buffa, J; DiDonato, JA; Finke, J; Fisher, EA; Hatala, D; Hazen, SL; Klipfell, E; Lindner, D; Parker, Y; Parsons-Wingerter, P; Rayman, P; Smith, JD; Tallant, TC; Wang, Z; Yusufishaq, MSS; Zamanian-Daryoush, M | 1 |
| Huang, YL; Lan, SY; Lee, H; Lin, YC; Wu, PY | 1 |
| Araki, M; Dong, Y; Fukushima, N; Hirane, M; Kitayoshi, M; Tanabe, E; Tsujiuchi, T | 1 |
| Abdel-Latif, A; Morris, AJ; Ratajczak, MZ; Schneider, G; Sellers, ZP | 1 |
| Benesch, MG; Brindley, DN; Curtis, JM; Dewald, J; McMullen, TP; Patwardhan, N; Santos, WL; Tang, X; Zhao, YY | 1 |
| Bennett, DC; Faller, WJ; Herd, R; Insall, RH; Jones, R; Kalna, G; Knecht, DA; Lindsay, C; Machesky, LM; Muinonen-Martin, AJ; Sansom, OJ; Smethurst, E; Susanto, O; Veltman, DM; Wakelam, MJ; Zhang, Q | 1 |
| Ambatipudi, S; Clézardin, P; Grunewald, TG; Leblanc, R; Peyruchaud, O; Ribeiro, J; Sahay, D | 1 |
| Bhuwania, R; Failla, AV; Gromova, K; Izbicki, JR; Kneussel, M; Lange, T; Lin, YN; Linder, S; Riecken, K; Windhorst, S | 1 |
| Cai, Q; Fan, Q; Xu, Y | 1 |
| Furukawa, S; Handa, H; Hashimoto, A; Hashimoto, S; Mikami, S; Oikawa, T; Okada, Y; Onodera, Y; Oya, M; Sabe, H; Sugino, H; Yoshikawa, A | 1 |
| Boutin, JA; Ferry, G | 1 |
| Kirmani, K; Li, H; Steinmetz, R; Wang, D; Xu, Y; Zhang, H; Zhao, Z | 1 |
| Fishman, DA; Wang, F | 1 |
| Collins, J; Marino, N; Marshall, JC; Steeg, P | 1 |
| Aoki, J; Bendriss-Vermare, N; Bollen, M; Clézardin, P; David, M; Descotes, F; Deux, B; Grès, S; Jansen, S; Peyruchaud, O; Ribeiro, J; Saez, S; Saulnier-Blache, JS; Serre, CM; Wannecq, E | 1 |
| Bekele, R; Brindley, DN; Capatos, D; Samadi, N; Sariahmetoglu, M; Venkatraman, G | 1 |
| Chen, H; Huang, S; Pan, ZK; Wu, X | 1 |
| Du, J; Gu, L; Hu, Z; Lu, X; Sun, C; Yang, Y; Zheng, D; Zhu, Y | 1 |
| Choi, JW; Kim, EK; Kim, HS; Kim, KT; Lee, DS; Lim, S; Oh, K; Park, JM; Ryu, SH; Seo, JK; Seok, H; Suh, PG | 1 |
| Goldsmith, PK; Heger, CD; Kelly, K; Lake, R; Merino, M; Raffeld, M; Ward, Y; Yin, JJ | 1 |
| Im, DS; Ishii, S; Kimura, T; Komachi, M; Mogi, C; Ohta, H; Okajima, F; Sato, K; Takeyoshi, I; Tobo, M; Tomura, H; Yamada, T; Yanagida, K | 1 |
| Chou, LY; Huang, RY; Liao, CK; Wang, SH; Wen, CC; Wu, JC | 1 |
| Boyon, C; D'Anjou, F; Day, R; Desmons, A; Farré, I; Fournier, I; Leblanc, E; Longuespée, R; Ly, K; Salzet, M; Vinatier, D; Wisztorski, M | 1 |
| Dong, Z; Korkina, O; Marullo, A; Ruggieri, R; Symons, M; Warshaw, G | 1 |
| Gupta, GP; Massagué, J | 1 |
| Bordet, JC; Boucharaba, A; Clézardin, P; Grès, S; Guglielmi, J; Peyruchaud, O; Saulnier-Blache, JS; Serre, CM | 1 |
| Fishman, DA; Kang, S; Meng, Y | 1 |
| Kondo, M; Nishihira, J; Sasaki, F; Sato, Y; Sun, B; Todo, S; Yoshiki, T | 1 |
| Christodoulou, E; Goding, JW; Kikuchi, K; Moolenaar, WH; Nagano, T; Perrakis, A; Ruurs, P; Takakusa, H; van Meeteren, LA | 1 |
| Berk, M; Jiang, Y; Powell, CT; Singh, LS; Tan, H; Xu, Y; Yin, L | 1 |
| Bordet, JC; Boucharaba, A; Clézardin, P; Guglielmi, J; Peyruchaud, O; Serre, CM | 1 |
| Baker, DL; Bandle, RW; Bittman, R; Byun, HS; Fan, D; Fujiwara, Y; Kobayashi, S; Koh, E; Mills, GB; Murakami-Murofushi, K; Murofushi, H; Murph, M; Pigg, KR; Tigyi, G; Tsukahara, R; Uchiyama, A | 1 |
| Belinson, J; Berk, M; Escobar, PF; Kim, KS; Kwak, YG; Mok, SC; Sengupta, S; Xu, Y | 1 |
| Belinson, J; Berk, MP; Escobar, P; Kim, KS; Li, W; Lindner, DJ; Oates, R; Sengupta, S; Williams, B; Xu, Y | 1 |
| Brinkmann, V; Lynch, KR; Moolenaar, WH; Saulnier-Blache, JS; van Meeteren, LA | 1 |
8 review(s) available for lysophosphatidic acid and Neoplasm Metastasis
| Article | Year |
|---|---|
Platelets as crucial partners for tumor metastasis: from mechanistic aspects to pharmacological targeting.
Topics: Animals; Aspirin; Blood Platelets; Eicosanoids; Epithelial-Mesenchymal Transition; Humans; Lysophospholipids; Molecular Targeted Therapy; Neoplasm Metastasis; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Purinergic P2Y Receptor Antagonists; Receptors, Prostaglandin E, EP3 Subtype | 2017 |
Platelets, autotaxin and lysophosphatidic acid signalling: win-win factors for cancer metastasis.
Topics: Animals; Blood Platelets; Humans; Lysophospholipids; Megakaryocytes; Neoplasm Metastasis; Neoplasms; Phosphoric Diester Hydrolases; Signal Transduction | 2018 |
Autotaxin.
Topics: Enzyme Inhibitors; Humans; Lysophospholipids; Multienzyme Complexes; Neoplasm Metastasis; Neoplasms; Obesity; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases | 2009 |
Lysophosphatidic acid and invasion.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cyclooxygenase 2; Diterpenes; Female; Humans; Interleukins; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Membrane Lipids; Mice; Multienzyme Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; Ovarian Neoplasms; Peptide Hydrolases; Phosphodiesterase I; Phospholipases A; Phosphoric Diester Hydrolases; Pyrophosphatases; Receptors, Lysophosphatidic Acid; Signal Transduction; Sphingosine; Vascular Endothelial Growth Factor A | 2009 |
The Nm23-H1 metastasis suppressor as a translational target.
Topics: Animals; Antineoplastic Agents; Genetic Therapy; Humans; Lysophospholipids; Medroxyprogesterone Acetate; Mice; Neoplasm Metastasis; NM23 Nucleoside Diphosphate Kinases; Translational Research, Biomedical | 2010 |
Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance.
Topics: Animals; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Male; Mice; Multienzyme Complexes; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Phosphatidate Phosphatase; Phosphodiesterase I; Phospholipase D; Phosphoric Diester Hydrolases; Pyrophosphatases; Signal Transduction; Sphingosine | 2011 |
Ovarian cancer molecular pathology.
Topics: Animals; CA-125 Antigen; Cell Proliferation; Female; Humans; I-kappa B Kinase; Lysophospholipids; MAP Kinase Signaling System; Neoplasm Metastasis; NF-kappa B; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Proteomics; Receptors, Estrogen; Signal Transduction | 2012 |
Platelets and metastasis revisited: a novel fatty link.
Topics: Blood Platelets; Bone and Bones; Breast Neoplasms; Cell Line, Tumor; Disease Progression; Female; Humans; Lysophospholipids; Models, Biological; Neoplasm Metastasis; Neovascularization, Pathologic; Osteolysis; Ovarian Neoplasms | 2004 |
35 other study(ies) available for lysophosphatidic acid and Neoplasm Metastasis
| Article | Year |
|---|---|
PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling.
Topics: Breast Neoplasms; Cytomegalovirus; Cytomegalovirus Infections; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; MCF-7 Cells; Neoplasm Metastasis; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction; Tumor Microenvironment; Virus Internalization | 2021 |
LPA3 is a precise therapeutic target and potential biomarker for ovarian cancer.
Topics: Animals; Biomarkers, Tumor; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Female; Gene Expression Regulation, Neoplastic; GTP-Binding Proteins; Humans; Immunohistochemistry; Lysophospholipids; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; Signal Transduction | 2022 |
N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Chemotaxis; Female; Humans; Lysophospholipids; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Protein Transport; Rats; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein; Signal Transduction; Sorting Nexins; Wiskott-Aldrich Syndrome Protein, Neuronal | 2019 |
Lysophosphatidic acid-RAGE axis promotes lung and mammary oncogenesis via protein kinase B and regulating tumor microenvironment.
Topics: Animals; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Gene Knockdown Techniques; Humans; Lung Neoplasms; Lymphocytes, Tumor-Infiltrating; Lysophospholipids; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Proto-Oncogene Proteins c-akt; Receptor for Advanced Glycation End Products; Signal Transduction; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2020 |
Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6.
Topics: Animals; Cell Line, Tumor; Down-Regulation; Epithelial Cells; Fallopian Tubes; Female; HEK293 Cells; Humans; Lysophospholipids; Mice, Nude; Mutation; Neoplasm Metastasis; Phosphoric Monoester Hydrolases; Signal Transduction; Tumor Suppressor Protein p53 | 2019 |
Real-time motion analysis reveals cell directionality as an indicator of breast cancer progression.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Migration Assays; Cell Movement; Disease Progression; Epidermal Growth Factor; Female; Humans; Lysophospholipids; Neoplasm Metastasis; Phenotype; Tumor Stem Cell Assay | 2013 |
The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.
Topics: Animals; Antigen Presentation; Antineoplastic Agents; Apolipoprotein A-I; Apolipoprotein A-II; Carcinogenesis; Cardiotonic Agents; Cell Line, Tumor; Cell Proliferation; Dendritic Cells; Female; Humans; Immunity; Immunocompetence; Lipoproteins, HDL; Lysophospholipids; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Remission Induction; Survival Analysis; Tumor Microenvironment | 2013 |
Aromatic hydrocarbon receptor inhibits lysophosphatidic acid-induced vascular endothelial growth factor-A expression in PC-3 prostate cancer cells.
Topics: Angiogenesis Inducing Agents; Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Line, Tumor; HEK293 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Male; Neoplasm Metastasis; Neovascularization, Pathologic; Prostatic Neoplasms; Receptors, Aryl Hydrocarbon; Signal Transduction; Vascular Endothelial Growth Factor A | 2013 |
Downregulation of activation factors of endothelia and fibroblasts via lysophosphatidic acid signaling in a mouse lung cancer LL/2 cell line.
Topics: 3T3 Cells; Animals; Cell Movement; Endothelial Cells; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lysophospholipids; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Neovascularization, Pathologic; Receptors, Lysophosphatidic Acid; Signal Transduction; Vascular Endothelial Growth Factor A | 2013 |
Bioactive lipids, LPC and LPA, are novel prometastatic factors and their tissue levels increase in response to radio/chemotherapy.
Topics: Animals; Bone Marrow; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Chemotactic Factors; Drug Resistance, Neoplasm; Gamma Rays; Humans; Isoxazoles; Lysophosphatidylcholines; Lysophospholipids; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, SCID; Neoplasm Metastasis; Propionates; Receptors, G-Protein-Coupled; Rhabdomyosarcoma; Tumor Microenvironment; Vincristine | 2014 |
Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression; Humans; Lysophospholipids; Mice; Neoplasm Metastasis; Phosphatidate Phosphatase; Signal Transduction | 2014 |
Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal.
Topics: Animals; Cell Movement; Chemotaxis; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Melanoma; Mice; Neoplasm Metastasis | 2014 |
The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Heterografts; Homeodomain Proteins; Humans; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Receptors, Lysophosphatidic Acid; Signal Transduction; Transcription Factors; Transfection; Zinc Finger E-box-Binding Homeobox 1 | 2015 |
Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion.
Topics: Actin Cytoskeleton; Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Cell Adhesion; Colonic Neoplasms; Formins; HCT116 Cells; HEK293 Cells; Humans; Integrin beta1; Lysophospholipids; Mice, SCID; Microscopy, Fluorescence; Microtubules; Neoplasm Metastasis; RNA Interference; Time-Lapse Imaging; Transplantation, Heterologous | 2015 |
FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cystadenocarcinoma, Serous; Disease Progression; Dose-Response Relationship, Drug; Female; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Phosphoproteins; RNA Interference; Signal Transduction; Transcription Factors; Transcription, Genetic; YAP-Signaling Proteins | 2015 |
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Adult; Aged; Aged, 80 and over; Amides; Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Immunohistochemistry; Indoles; Isoxazoles; Kidney Neoplasms; Lysophospholipids; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Nerve Tissue Proteins; Propionates; Pyridines; Pyrroles; Receptors, Lysophosphatidic Acid; Signal Transduction; Sirolimus; Sunitinib; Triazoles | 2016 |
Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice.
Topics: Animals; Arachidonate 15-Lipoxygenase; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooxygenase 1; Female; Group IV Phospholipases A2; Humans; Immunocompetence; Lysophospholipids; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Tumor Stem Cell Assay | 2009 |
Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts.
Topics: Animals; Blood Platelets; Bone and Bones; Bone Neoplasms; Cell Proliferation; Humans; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Multienzyme Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Osteoclasts; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases | 2010 |
Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Animals; Blotting, Western; Cell Line, Tumor; Cell Movement; Cytoskeletal Proteins; Female; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Mice, Nude; Middle Aged; Multiprotein Complexes; Neoplasm Metastasis; Neoplasm Staging; Neoplasms, Experimental; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; RNA Interference; SOS1 Protein; Transplantation, Heterologous; Young Adult | 2010 |
Lysophosphatidic acid induces MDA-MB-231 breast cancer cells migration through activation of PI3K/PAK1/ERK signaling.
Topics: Acetylcysteine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Lysophospholipids; Neoplasm Metastasis; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; Signal Transduction | 2010 |
Activation of AMP-activated protein kinase is essential for lysophosphatidic acid-induced cell migration in ovarian cancer cells.
Topics: AMP-Activated Protein Kinases; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Line, Tumor; Cell Membrane; Cell Movement; Cytoskeleton; Enzyme Activation; Female; Humans; Lysophospholipids; Neoplasm Metastasis; Ovarian Neoplasms; Phospholipase C beta; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein | 2011 |
LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.
Topics: Antigens, CD; Cell Line, Tumor; Disease Progression; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits, G12-G13; Guanosine Triphosphate; Humans; Lysophospholipids; Male; Neoplasm Invasiveness; Neoplasm Metastasis; Prostatic Neoplasms; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein; Signal Transduction | 2011 |
Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.
Topics: Animals; Ascites; Cell Line, Tumor; Cell Movement; Humans; Isoxazoles; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Peritoneal Neoplasms; Propionates; Receptors, Lysophosphatidic Acid; Xenograft Model Antitumor Assays | 2012 |
Lysophosphatidic acid modulates the association of PTP1B with N-cadherin/catenin complex in SKOV3 ovarian cancer cells.
Topics: Adherens Junctions; Cadherins; Catenins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Lysophospholipids; Multiprotein Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-fyn; RNA Interference; RNA, Small Interfering; Signal Transduction; src-Family Kinases | 2012 |
The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion.
Topics: Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Laminin; Lysophospholipids; Models, Biological; Myosins; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proteoglycans; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; rhoC GTP-Binding Protein; Signal Transduction | 2013 |
Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer.
Topics: Animals; Blood Platelets; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cricetinae; Culture Media; Cytokines; Disease Progression; Dose-Response Relationship, Drug; Doxycycline; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Interleukin-6; Interleukin-8; Ki-67 Antigen; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogens; Models, Biological; Neoplasm Metastasis; Osteoclasts; Osteolysis; Phospholipase D; Platelet Activation; Platelet Aggregation; Reverse Transcriptase Polymerase Chain Reaction; RNA; Time Factors; Transfection | 2004 |
Lysophosphatidic acid stimulates fas ligand microvesicle release from ovarian cancer cells.
Topics: Blotting, Western; Cytoskeleton; Enzyme-Linked Immunosorbent Assay; Fas Ligand Protein; Female; Flow Cytometry; Humans; Lysophospholipids; Membrane Glycoproteins; Microtubules; Neoplasm Metastasis; Ovarian Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2005 |
Macrophage migration inhibitory factor promotes tumor invasion and metastasis via the Rho-dependent pathway.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Female; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Macrophage Migration-Inhibitory Factors; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Protein Serine-Threonine Kinases; rho GTP-Binding Proteins; rho-Associated Kinases; RNA Interference; RNA, Small Interfering; Signal Transduction | 2005 |
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.
Topics: Allosteric Site; Binding Sites; Biosensing Techniques; Blotting, Western; Catalysis; Catalytic Domain; Cell Line; Cell Movement; DNA, Complementary; Dose-Response Relationship, Drug; Fluorescence Resonance Energy Transfer; Glucose-6-Phosphate Isomerase; Glycoproteins; Humans; Hydrolysis; Kinetics; Ligands; Lipid Metabolism; Lipids; Lysophosphatidylcholines; Lysophospholipids; Models, Chemical; Multienzyme Complexes; Mutagenesis; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Phosphodiesterase I; Phospholipase D; Phosphoric Diester Hydrolases; Pyrophosphatases; Recombinant Fusion Proteins; Recombinant Proteins; Sphingosine; Transfection | 2005 |
KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha.
Topics: Animals; Cell Movement; Cell Proliferation; Down-Regulation; Female; Humans; Kisspeptins; Lysophospholipids; Mice; Mice, Nude; Neoplasm Metastasis; Ovarian Neoplasms; Protein Kinase C-alpha; Proteins; Transplantation, Heterologous; Tumor Suppressor Proteins | 2005 |
The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytokines; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Lysophospholipids; Mice; Neoplasm Metastasis; Osteoclasts; Propionates; Receptors, Lysophosphatidic Acid | 2006 |
Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis.
Topics: Antineoplastic Agents; Cell Line, Tumor; Culture Media, Conditioned; Humans; Lipid Metabolism; Lysophospholipids; Melanoma; Multienzyme Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphatidic Acids; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Recombinant Proteins; Spectrometry, Fluorescence | 2006 |
Hypoxia enhances lysophosphatidic acid responsiveness in ovarian cancer cells and lysophosphatidic acid induces ovarian tumor metastasis in vivo.
Topics: Cell Hypoxia; Cell Movement; Female; Humans; Lysophospholipids; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Tumor Cells, Cultured | 2006 |
Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion.
Topics: Animals; Cell Movement; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2007 |
Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.
Topics: Animals; Antineoplastic Agents; Female; Humans; Lysophospholipids; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Neoplasm Metastasis; Neovascularization, Pathologic; Organophosphates; Phosphodiesterase I; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrophosphatases; Sphingosine | 2008 |