lysophosphatidic acid and Invasiveness, Neoplasm

Topics: Cell Movement; Drug Resistance, Neoplasm; Humans; Lysophospholipids; Neoplasm Invasiveness; Neoplastic Stem Cells; Pancreatic Neoplasms; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid; Signal Transduction; Tumor Microenvironment

Topics: Animals; Cell Movement; Humans; Lysophospholipids; Neoplasm Invasiveness; Neoplasms; Oligonucleotide Array Sequence Analysis; Receptors, Lysophosphatidic Acid; Signal Transduction

Topics: Animals; Cell Movement; Humans; Lysophospholipids; Models, Biological; Neoplasm Invasiveness; Neoplasms; Receptors, Lysophosphatidic Acid; Signal Transduction

Topics: Animals; Breast Neoplasms; Cell Movement; Cell Proliferation; Female; Humans; Lysophospholipids; Neoplasm Invasiveness; Neoplasm Proteins; Phosphoric Diester Hydrolases; Signal Transduction

Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cyclooxygenase 2; Diterpenes; Female; Humans; Interleukins; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Membrane Lipids; Mice; Multienzyme Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; Ovarian Neoplasms; Peptide Hydrolases; Phosphodiesterase I; Phospholipases A; Phosphoric Diester Hydrolases; Pyrophosphatases; Receptors, Lysophosphatidic Acid; Signal Transduction; Sphingosine; Vascular Endothelial Growth Factor A

Topics: Cell Growth Processes; Cell Survival; Colorectal Neoplasms; Humans; Lysophospholipids; Neoplasm Invasiveness; Receptors, Lysophosphatidic Acid; Signal Transduction

Topics: Animals; Antineoplastic Agents; Humans; Lysophospholipids; Molecular Targeted Therapy; Neoplasm Invasiveness; Neoplasms; Organophosphonates; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid; Signal Transduction; Xenograft Model Antitumor Assays

Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Chemotaxis; Female; Humans; Lysophospholipids; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Protein Transport; Rats; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein; Signal Transduction; Sorting Nexins; Wiskott-Aldrich Syndrome Protein, Neuronal

Topics: Animals; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Gene Knockdown Techniques; Humans; Lung Neoplasms; Lymphocytes, Tumor-Infiltrating; Lysophospholipids; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Proto-Oncogene Proteins c-akt; Receptor for Advanced Glycation End Products; Signal Transduction; Tumor Microenvironment; Xenograft Model Antitumor Assays

Topics: Cell Line, Tumor; Discoidin Domain Receptor 2; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Phosphatidylinositol 3-Kinase; Signal Transduction; TOR Serine-Threonine Kinases

Topics: Cell Line, Tumor; Chemotaxis; Humans; Lysophospholipids; Melanoma; Neoplasm Invasiveness; Phosphatidate Phosphatase; Skin Neoplasms

Topics: Amphiregulin; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Enhancer of Zeste Homolog 2 Protein; Epithelial-Mesenchymal Transition; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; MCF-7 Cells; Neoplasm Invasiveness; Phosphorylation; Resveratrol; RNA, Small Interfering; Signal Transduction; Y-Box-Binding Protein 1

Topics: Cell Line, Tumor; Cell Movement; Humans; Lysophospholipids; Neoplasm Invasiveness; Neoplasm Proteins; Receptor, Notch1; Receptors, Lysophosphatidic Acid; Signal Transduction; Stomach Neoplasms

Topics: Apoptosis; Arrestins; beta-Arrestins; Blotting, Western; Breast; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Chemotaxis; Female; Humans; Immunoenzyme Techniques; Lysophospholipids; Neoplasm Invasiveness; Neoplasm Staging; ras GTPase-Activating Proteins; Real-Time Polymerase Chain Reaction; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Shelterin Complex; Signal Transduction; Telomere-Binding Proteins

Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Receptors, Lysophosphatidic Acid

Topics: Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Shape; Chemotaxis; Enzyme Activation; Extracellular Matrix; Female; Focal Adhesion Kinase 1; Focal Adhesions; Guanine Nucleotide Exchange Factors; Humans; Lysophospholipids; Myosin Light Chains; Neoplasm Invasiveness; Oncogene Proteins; Phosphorylation; Protein Binding; Protein Isoforms; Protein Processing, Post-Translational; Protein Transport; rhoA GTP-Binding Protein

Topics: 3T3 Cells; Animals; Cell Movement; Endothelial Cells; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lysophospholipids; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Neovascularization, Pathologic; Receptors, Lysophosphatidic Acid; Signal Transduction; Vascular Endothelial Growth Factor A

Topics: Angiogenesis Inhibitors; Animals; Carcinogenesis; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Female; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Kidney Neoplasms; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Microvessels; Neoplasm Invasiveness; Phosphoric Diester Hydrolases; Pyrroles; Signal Transduction; Sunitinib; Transcriptome; Tumor Burden; Xenograft Model Antitumor Assays

Topics: Actins; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; Female; Hepatocyte Growth Factor; Humans; Lysophospholipids; Mitogen-Activated Protein Kinases; Myosin-Light-Chain Kinase; Myosins; Neoplasm Invasiveness; rac GTP-Binding Proteins; rho GTP-Binding Proteins; Signal Transduction

Topics: Cell Line, Tumor; Cell Movement; Humans; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Receptors, Lysophosphatidic Acid; Sarcoma; Signal Transduction

Topics: Animals; Blood Platelets; Bone and Bones; Bone Neoplasms; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Integrin alphaVbeta3; Lysophospholipids; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Phosphoric Diester Hydrolases; Platelet Activation

Topics: Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Surface Extensions; Female; Focal Adhesions; GTP-Binding Protein alpha Subunit, Gi2; Humans; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Protein Transport; Rho Guanine Nucleotide Exchange Factors; src-Family Kinases; Tumor Cells, Cultured

Topics: Antineoplastic Agents; Breast Neoplasms; Cell Movement; Cell Proliferation; Curcumin; Female; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Matrix Metalloproteinases; MCF-7 Cells; Neoplasm Invasiveness; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

Topics: Cell Line, Tumor; Cell Movement; Humans; Lysophospholipids; Neoplasm Invasiveness; Pancreatic Neoplasms; Receptors, Lysophosphatidic Acid; Receptors, Purinergic; Receptors, Purinergic P2

Topics: Actins; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Enzyme Activation; Formins; HT29 Cells; Humans; Lysophospholipids; Neoplasm Invasiveness; Proteins; Pseudopodia; rho GTP-Binding Proteins; Rho Guanine Nucleotide Exchange Factors; rho-Associated Kinases; rhoA GTP-Binding Protein; rhoC GTP-Binding Protein; RNA Interference; RNA, Small Interfering; Serum Response Factor; Signal Transduction; Stress Fibers

Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cystadenocarcinoma, Serous; Disease Progression; Dose-Response Relationship, Drug; Female; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Phosphoproteins; RNA Interference; Signal Transduction; Transcription Factors; Transcription, Genetic; YAP-Signaling Proteins

Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Disease Progression; Extracellular Matrix; Heterografts; Humans; Lysophospholipids; Male; Neoplasm Invasiveness; NF-kappa B; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; rhoA GTP-Binding Protein; Signal Transduction

Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Adult; Aged; Aged, 80 and over; Amides; Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Immunohistochemistry; Indoles; Isoxazoles; Kidney Neoplasms; Lysophospholipids; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Nerve Tissue Proteins; Propionates; Pyridines; Pyrroles; Receptors, Lysophosphatidic Acid; Signal Transduction; Sirolimus; Sunitinib; Triazoles

Topics: Adenocarcinoma; Animals; Cell Line, Tumor; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mitochondria; Neoplasm Invasiveness; Ovarian Neoplasms; Oxidative Phosphorylation; Phosphatidylinositol 3-Kinases; Proto-Oncogene Protein c-ets-1; Sequence Analysis, RNA

Topics: Antigens, CD; Cadherins; Cell Adhesion; Cell Line, Tumor; Female; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Ovarian Neoplasms; Pertussis Toxin; rac GTP-Binding Proteins; Sphingosine; Urokinase-Type Plasminogen Activator

Topics: Blotting, Western; Breast Neoplasms; Cell Movement; Cell Proliferation; Chemotaxis; Colonic Neoplasms; ErbB Receptors; Humans; Interleukin-6; Interleukin-8; Lysophospholipids; Neoplasm Invasiveness; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Stomach Neoplasms; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation; Urokinase-Type Plasminogen Activator

Topics: Adenocarcinoma; Blotting, Western; Cell Line, Tumor; Cell Movement; Cytoskeletal Proteins; Cytoskeleton; Enzyme Activation; Flow Cytometry; Gene Expression; Humans; Lysophospholipids; Neoplasm Invasiveness; Oncogene Proteins; Polymerase Chain Reaction; rhoA GTP-Binding Protein; RNA Interference; RNA, Messenger; Stomach Neoplasms

Topics: Animals; Cell Line, Tumor; Cell Movement; Cells, Cultured; Colonic Neoplasms; Enzyme Activation; Female; Fibroblasts; Humans; Lysophospholipids; Male; Mice; Mice, Knockout; Neoplasm Invasiveness; Protein Isoforms; Proto-Oncogene Proteins c-akt; rac GTP-Binding Proteins; Receptors, Lysophosphatidic Acid; Receptors, Purinergic; Signal Transduction; Tissue Distribution

Topics: Cell Adhesion; Cell Communication; Cell Line, Tumor; Endometrial Neoplasms; Enzyme Activation; Extracellular Matrix; Female; Gene Silencing; Humans; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 7; Neoplasm Invasiveness; Receptors, Lysophosphatidic Acid; RNA, Small Interfering; Transfection

Topics: Ascites; Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Epidermal Growth Factor; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Isoxazoles; Laminin; Lysophospholipids; Neoplasm Invasiveness; Pancreatic Neoplasms; Pertussis Toxin; Propionates; Proteoglycans; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein; RNA, Small Interfering

Topics: Cell Line, Tumor; Fibrosarcoma; Humans; JNK Mitogen-Activated Protein Kinases; Lysophospholipids; MAP Kinase Signaling System; Matrix Metalloproteinase 3; Multienzyme Complexes; Neoplasm Invasiveness; Phosphodiesterase I; Phosphoric Diester Hydrolases; Phosphorylation; Protein Kinase Inhibitors; Pyrophosphatases; Recombinant Proteins; RNA, Messenger; Up-Regulation

Topics: Animals; Arachidonate 15-Lipoxygenase; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooxygenase 1; Female; Group IV Phospholipases A2; Humans; Immunocompetence; Lysophospholipids; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Tumor Stem Cell Assay

Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Movement; Cell Survival; Curcumin; Dose-Response Relationship, Drug; Female; Humans; Interleukin-6; Interleukin-8; Janus Kinases; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Signal Transduction; STAT3 Transcription Factor; Transfection; Tyrphostins

Topics: Cell Line, Tumor; Epithelial Cells; Female; Humans; Lysophospholipids; Neoplasm Invasiveness; Neuropilin-1; Neuropilin-2; Ovarian Neoplasms; RNA Interference; RNA, Small Interfering; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Carcinoma; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Female; Humans; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Ovarian Neoplasms; rho-Associated Kinases; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Topics: Carcinoma, Endometrioid; Cell Growth Processes; Cell Line, Tumor; Endometrial Neoplasms; Enzyme Activation; Female; Fibrosarcoma; Humans; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 7; Matrix Metalloproteinases; Neoplasm Invasiveness; RNA, Messenger

Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Female; GTP-Binding Proteins; Hepatocyte Growth Factor; Humans; Interleukin-8; Lysophospholipids; Neoplasm Invasiveness; NF-kappa B; Phosphotyrosine; Transcription Factor AP-1

Topics: Animals; Blood Platelets; Bone and Bones; Bone Neoplasms; Cell Proliferation; Humans; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Multienzyme Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Osteoclasts; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases

Topics: Actins; Adult; Aged; Carcinoma, Ovarian Epithelial; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Female; Fibroblasts; Humans; Immunohistochemistry; Lysophospholipids; Middle Aged; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Prognosis; Stromal Cells

Topics: Actins; Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Apoptosis; ATPases Associated with Diverse Cellular Activities; Cell Line, Tumor; Cell Movement; fas Receptor; Fas-Associated Death Domain Protein; Glioma; HEK293 Cells; Humans; LIM Domain Proteins; Lysophospholipids; Models, Biological; Neoplasm Invasiveness; Phosphorylation; Proteasome Endopeptidase Complex; Signal Transduction; Transcription Factor RelA; Transcription Factors; Tyrosine

Topics: Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Female; Humans; Lysophospholipids; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; RNA, Messenger; RNA, Small Interfering; Transfection

Topics: Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Lysophospholipids; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Receptors, Lysophosphatidic Acid; Signal Transduction

Topics: Adenocarcinoma; Adenomatous Polyposis Coli; Animals; Cell Movement; Colonic Neoplasms; Disease Models, Animal; Genes, APC; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; HCT116 Cells; Humans; Inositol Phosphates; JNK Mitogen-Activated Protein Kinases; Lysophospholipids; Membrane Proteins; Mice; Neoplasm Invasiveness; NF-kappa B; Phospholipase C beta; Phosphoproteins; Receptors, Lysophosphatidic Acid; RNA Interference; Signal Transduction; Sodium-Hydrogen Exchangers; Time Factors; Tissue Array Analysis; Transfection

Topics: Carcinoma, Ovarian Epithelial; Cell Line, Tumor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Matrix Metalloproteinases; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; NF-kappa B; Ovarian Neoplasms; Signal Transduction; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

Topics: Antigens, CD; Cell Line, Tumor; Disease Progression; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits, G12-G13; Guanosine Triphosphate; Humans; Lysophospholipids; Male; Neoplasm Invasiveness; Neoplasm Metastasis; Prostatic Neoplasms; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein; Signal Transduction

Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Humans; Liver Neoplasms; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Signal Transduction

Topics: Antibodies; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Flavonoids; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; MAP Kinase Signaling System; Neoplasm Invasiveness; Progranulins; RNA, Small Interfering; Transfection

Topics: Amides; Cell Line, Tumor; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Neoplasm Invasiveness; NF-kappa B; Nitriles; Ovarian Neoplasms; Peptide Hydrolases; Pyridines; rho-Associated Kinases; Sulfones; Urokinase-Type Plasminogen Activator

Topics: Animals; Ascites; Cell Line, Tumor; Cell Movement; Humans; Isoxazoles; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Peritoneal Neoplasms; Propionates; Receptors, Lysophosphatidic Acid; Xenograft Model Antitumor Assays

Topics: Adherens Junctions; Cadherins; Catenins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Lysophospholipids; Multiprotein Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-fyn; RNA Interference; RNA, Small Interfering; Signal Transduction; src-Family Kinases

Topics: Animals; Cell Line, Tumor; Cell Movement; Cricetinae; Gene Knockdown Techniques; Lysophospholipids; Neoplasm Invasiveness; Pancreatic Neoplasms; Receptors, Lysophosphatidic Acid

Topics: Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Colonic Neoplasms; Endothelium, Vascular; Humans; Lysophospholipids; Neoplasm Invasiveness; Real-Time Polymerase Chain Reaction; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor C

Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; ATPases Associated with Diverse Cellular Activities; bcl-2-Associated X Protein; Caspases; Cell Line; Cell Line, Tumor; Cell Proliferation; CHO Cells; Cricetinae; DNA Fragmentation; Epithelial Cells; Fibroblasts; Human Umbilical Vein Endothelial Cells; Humans; LIM Domain Proteins; Lysophospholipids; MAP Kinase Signaling System; Mice; Mice, Knockout; Neoplasm Invasiveness; Phosphoproteins; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Rats; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Signal Transduction; Sodium-Hydrogen Exchangers; Transcription Factors

Topics: Adenocarcinoma; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cricetinae; Diphosphates; Gene Knockdown Techniques; Genes, ras; Glycerol; Lysophospholipids; Neoplasm Invasiveness; Pancreatic Neoplasms; Receptors, Lysophosphatidic Acid; Up-Regulation

Topics: Cell Line, Tumor; Cell Movement; Humans; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasms; Receptors, Lysophosphatidic Acid; Sarcoma; Signal Transduction

Topics: Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Laminin; Lysophospholipids; Models, Biological; Myosins; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proteoglycans; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; rhoC GTP-Binding Protein; Signal Transduction

Topics: 3T3 Cells; Animals; Carcinoma; Cell Line, Tumor; Culture Media, Conditioned; Hepatocyte Growth Factor; Humans; Immunoblotting; Integrin alpha6beta4; Integrin beta4; Lysophospholipids; Mice; Neoplasm Invasiveness; Precipitin Tests; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Receptors, Growth Factor; Retroviridae; RNA Interference; RNA, Small Interfering; Time Factors

Topics: Cell Line, Tumor; Cell Movement; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-8; Lysophospholipids; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Ovarian Neoplasms

Topics: Adenoviridae; Animals; Binding Sites; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Genes, Dominant; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Mutation; Neoplasm Invasiveness; NF-kappa B; Ovarian Neoplasms; Promoter Regions, Genetic; raf Kinases; ras Proteins; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Signal Transduction; Transfection; Up-Regulation; Urokinase-Type Plasminogen Activator

Topics: Apoptosis; Caspases; Cell Membrane; Cell Movement; Cytosol; Down-Regulation; Enzyme Activation; Fas Ligand Protein; fas Receptor; Female; Humans; Immunoglobulin M; Lysophospholipids; Membrane Glycoproteins; Neoplasm Invasiveness; Ovarian Neoplasms

Topics: Animals; Blotting, Western; Cell Line, Tumor; Female; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Macrophage Migration-Inhibitory Factors; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Protein Serine-Threonine Kinases; rho GTP-Binding Proteins; rho-Associated Kinases; RNA Interference; RNA, Small Interfering; Signal Transduction

Topics: Actins; Acute-Phase Proteins; Cell Shape; Cell Survival; Cytoskeletal Proteins; Diterpenes; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Humans; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Paxillin; Phosphoproteins; Phosphorylation; Tumor Cells, Cultured

Topics: Antibodies, Monoclonal; Cell Line, Tumor; Cell Movement; Cinnamates; Drug Interactions; Enzyme Activation; Female; Humans; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Ovarian Neoplasms; Urokinase-Type Plasminogen Activator; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

Topics: Anoikis; Breast Neoplasms; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; Epithelial Cells; Genes, Dominant; Humans; Lysophospholipids; Neoplasm Invasiveness; p21-Activated Kinases; Phosphorylation; Plasmids; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Signal Transduction; Time Factors; Transfection

Topics: Actins; Amides; Astrocytoma; Cell Line, Tumor; Cell Movement; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mutation; Neoplasm Invasiveness; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; rac1 GTP-Binding Protein; rho-Associated Kinases; Transfection

Topics: Cell Line, Tumor; Collagen; Drug Combinations; Humans; Laminin; Lysophospholipids; Male; Neoplasm Invasiveness; NF-kappa B; Prostatic Neoplasms; Proteoglycans; rhoA GTP-Binding Protein

Topics: Blotting, Western; Cell Line, Tumor; Cell Movement; Humans; Liver Neoplasms; Lysophospholipids; Neoplasm Invasiveness; rho GTP-Binding Proteins; Signal Transduction

Topics: Antineoplastic Agents; Cell Line, Tumor; Culture Media, Conditioned; Humans; Lipid Metabolism; Lysophospholipids; Melanoma; Multienzyme Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphatidic Acids; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Recombinant Proteins; Spectrometry, Fluorescence

Topics: Cell Hypoxia; Cell Movement; Female; Humans; Lysophospholipids; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Tumor Cells, Cultured

Topics: Blotting, Western; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoprecipitation; Lysophospholipids; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Transfection; Vascular Endothelial Growth Factor A

Topics: Carcinoma; Female; Humans; Lysophospholipids; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; RNA Interference; RNA, Small Interfering; Tumor Cells, Cultured

Topics: Animals; Cell Movement; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Topics: cdc42 GTP-Binding Protein; Cell Movement; Collagen; Extracellular Matrix; GTP-Binding Proteins; Humans; Lipids; Lysophospholipids; Matrix Metalloproteinase 14; Matrix Metalloproteinases; Models, Biological; Neoplasm Invasiveness; Neoplasms; rac1 GTP-Binding Protein; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; RNA, Small Interfering; Signal Transduction; Sphingosine; Time Factors; Tumor Cells, Cultured

Topics: Cell Communication; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemotaxis; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Interleukin-6; Lysophospholipids; Neoplasm Invasiveness; Osteonectin; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; RNA, Messenger; Signal Transduction

Topics: Animals; Female; Lysophospholipids; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Ovarian Neoplasms; Peritoneal Neoplasms; Random Allocation; Transplantation, Heterologous; Tumor Burden

Topics: Breast Neoplasms; Cell Line, Tumor; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Lysophospholipids; Neoplasm Invasiveness; Propionates; Protein Isoforms; Receptors, Lysophosphatidic Acid; rho GTP-Binding Proteins; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction

Topics: Actins; Biocompatible Materials; Blotting, Western; Cadherins; Carcinoma; Cell Adhesion; Cell Line, Tumor; Collagen; Drug Combinations; Extracellular Matrix; Female; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Humans; Laminin; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Proteoglycans; Sphingosine

Topics: Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Cell Line, Tumor; Female; Humans; Lysophospholipids; Neoplasm Invasiveness; NF-kappa B; Ovarian Neoplasms; Protein Kinase C-alpha; ras Proteins; Signal Transduction; Up-Regulation; Urokinase-Type Plasminogen Activator

Topics: Cadherins; Cell Line, Tumor; Down-Regulation; Female; Humans; Immunoglobulin Fc Fragments; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Protein Structure, Tertiary; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urokinase-Type Plasminogen Activator

Topics: Actin Depolymerizing Factors; Actins; Animals; Ascites; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cytoskeleton; Destrin; Epithelium; Focal Adhesions; Lim Kinases; Lysophospholipids; Microfilament Proteins; Neoplasm Invasiveness; Neoplasm Proteins; Phosphoric Monoester Hydrolases; Phosphorylation; Rats; RNA, Small Interfering

Topics: Cell Line, Tumor; Cell Movement; Cell Nucleus; Collagen; Drug Combinations; Gene Expression Regulation, Neoplastic; Humans; Laminin; Lysophospholipids; Neoplasm Invasiveness; NF-kappa B; Promoter Regions, Genetic; Proteoglycans; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Stomach Neoplasms; Transcription Factor AP-1; Up-Regulation

Topics: Actomyosin; ADP Ribose Transferases; Animals; Botulinum Toxins; Carcinoma, Hepatocellular; Epithelial Cells; GTP-Binding Proteins; Humans; Liver Neoplasms; Lysophospholipids; Mesentery; Models, Biological; Myosin Light Chains; Neoplasm Invasiveness; Phosphorylation; Rats; rhoA GTP-Binding Protein; Signal Transduction; Tumor Cells, Cultured

Topics: Animals; Antineoplastic Agents; Benzenesulfonamides; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Lung; Lung Neoplasms; Melanoma; Mice; Models, Molecular; Neoplasm Invasiveness; Neoplastic Stem Cells; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship; Sulfonamides