lysophosphatidic acid has been researched along with Innate Inflammatory Response in 71 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 13 (18.31) | 29.6817 |
2010's | 46 (64.79) | 24.3611 |
2020's | 12 (16.90) | 2.80 |
Authors | Studies |
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Guo, F; Guo, Z; Huang, L; Li, Y; Qian, W; Xu, Y; Yin, Y; Zhu, W | 1 |
Fan, G; Gao, M; Jia, Y; Li, Y; Suo, X; Yang, X; Zong, Y | 1 |
Ban, KY; Jun, HS; Kim, D; Lee, GH | 1 |
Jiang, S; Li, M; Yang, H | 1 |
Ueda, H | 1 |
Bernhart, E; Joshi, L; Koyani, CN; Malle, E; Plastira, I; Reicher, H; Sattler, W; Strohmaier, H | 1 |
Kraemer, M; Morris, AJ; Smyth, SS; Van Hoose, P; Yang, L | 1 |
Brindley, DN; Hemmings, DG | 1 |
Ayata, CK; Das, S; Diaz, OE; Doñas, C; Franc, Y; Geier, F; Hernández, PP; Hruz, P; Kaya, B; Kaymak, T; Melhem, H; Morales, RA; Niess, JH; Villablanca, EJ; Wuggenig, P | 1 |
Chun, J; de Fonseca, FR; Estivill-Torrús, G; Fernández, O; Fransson, J; García-Díaz, B; Gómez-Conde, AI; Leyva, L; Louapre, C; Romero-Imbroda, J; Van-Evercooren, AB; Zujovic, V | 1 |
Abdel-Latif, A; Abo-Aly, M; Al-Darraji, A; Chelvarajan, L; Gao, E; Hernandez, G; Levitan, BM; Morris, AJ; Peng, H; R Donahue, R; Shokri, E; Smyth, SS; Tripathi, H | 1 |
Mathew, D; Torres, RM | 1 |
Kamato, D; Little, PJ; Xu, S; Zhou, Y | 1 |
Bascands, JL; Casemayou, A; Denis, C; Faguer, S; Gilet, M; Goudounéche, D; Marsal, D; Mirzoyan, K; Saulnier-Blache, JS; Schanstra, JP | 1 |
Aoki, T; Hiyama, H; Kiso, T; Murai, N; Oka, H; Sekizawa, T; Watabiki, T | 1 |
Cenac, C; Chicanne, G; Gaits-Iacovoni, F; Gratacap, MP; Le Faouder, P; Minville, V; Mujalli, A; Payrastre, B; Severin, S; Vardon Bounes, F | 1 |
Benesch, MGK; Brindley, DN; Meng, G; Tang, X; Yang, Z | 1 |
González-Arenas, A; Valdés-Rives, SA | 1 |
Berger, R; Hankemeier, T; Harms, AC; Schoeman, JC; van Weeghel, M; Vreeken, RJ | 1 |
Guo, T; Li, F; Shen, X; Zhang, T; Zou, J | 1 |
Atsumi, GI; Inoue, K; Kudo, I; Murakami, M; Nakatani, Y | 1 |
Cook, KE; Fabiilli, ML; Nelson, DL; Zhao, Y | 1 |
Brindley, DN; Curtis, JM; McMullen, TPW; Meng, G; Tang, X; Yang, Z; Zhao, Y | 1 |
Chew, WS; Chun, J; Hay, NWJ; Herr, DR; Hind, T; Lee, JHM; Lim, SM; Ong, WY; Rivera, R; Srikanth, M | 1 |
Denning, TL; El-Rayes, B; Guo, L; Haque, A; He, P; Lin, S; Moolenaar, WH; Raeman, R; Yun, CC | 1 |
Brandon, JA; Halder, S; Kraemer, M; Morris, AJ; Smyth, SS; Ubele, M; Vandra, J | 1 |
Chen, QY; Deng, SJ; Dong, YL; Duan, XY; Fan, H; Liu, YJ; Nan, Z; Wu, H; Xu, M | 1 |
Morris, AJ; Smyth, SS | 1 |
Ackerman, SJ; Aidinis, V; Berdyshev, E; Christman, JW; Chun, J; Chung, S; Corbridge, SJ; Deng, J; Du, J; Fu, P; Gorshkova, IA; Jaffe, HA; Jarjour, NN; Kaffe, E; Karpurapu, M; Kelly, EA; Lee, YG; Li, Y; Morris, AJ; Natarajan, V; Ninou, I; Nyenhuis, S; Park, GY; Prestwich, GD; Ranjan, R; Smyth, SS; Xiao, L | 1 |
Anantharamaiah, GM; Buga, GM; Chattopadhyay, A; Danciger, JS; Farias-Eisner, R; Fogelman, AM; Gao, F; Grijalva, V; Hough, G; Lusis, AJ; Meriwether, D; Navab, M; Org, E; Pan, C; Reddy, ST; Smyth, SS; Su, F; Van Lenten, BJ; Wagner, AC | 1 |
Georas, SN | 1 |
Georas, SN; Knowlden, S | 1 |
Brandon, J; Escalante-Alcalde, D; Miriyala, S; Morris, AJ; Panchatcharam, M; Patil, P; Salous, AK; Smyth, SS; Sunkara, M; Wheeler, J | 1 |
Getz, GS; Reardon, CA | 1 |
Aoki, J; Kimoto, S; Morikawa, Y; Okudaira, S; Shimizu, Y; Tanaka, T; Tokumura, A | 1 |
Alnouti, Y; Bathena, SP; Cerutis, DR; Headen, KV; McVaney, TP; Miyamoto, T; Nunn, ME; Ogunleye, AO; Weston, MD | 1 |
Benesch, MG; Brindley, DN; Curtis, JM; McMullen, TP; Zhao, YY | 1 |
Bourgoin, SG; Davis, L; Fernandes, MJ; Poubelle, PE; Sardella, A; Zhao, C | 1 |
Flower, RJ; Gobbetti, T; Kusters, DH; McArthur, S; Perretti, M; Reutelingsperger, CP | 1 |
Exley, M; Lange, M; Nowak-Machen, M; Robson, SC; Usheva, A; Wu, S | 1 |
Ackerman, SJ; Berdyshev, E; Christman, JW; Natarajan, V; Nyenhuis, S; Park, GY | 1 |
Arola, L; Caimari, A; Calder, PC; Childs, CE; Del Bas, JM; Miles, EA; Paras Chavez, C; Rodriguez-Naranjo, MI; West, AL | 1 |
Brindley, DN; Curtis, JM; Tang, X; Wang, X; Zhao, YY | 1 |
Aoki, J; Kaibuchi, K; Kawana, H; Kiyama, H; Konishi, H; Makide, K; Nakamuta, S; Ohwada, T; Tokizane, K | 1 |
Aoki, J; Aozasa, K; Bai, Z; Fujita, N; Fukui, Y; Hayasaka, H; Hirosawa, M; Jin, S; Miyasaka, M; Nakasaki, T; Okudaira, S; Otani, K; Ozono, K; Tanaka, T; Tsuruo, T; Umemoto, E | 1 |
Aoki, J; Arima, N; Kano, K; Kitamura, H; Makide, K | 1 |
Barbolina, MV; Burkhalter, RJ; Forgacs, G; Hudson, LG; Liu, Y; Marga, F; Moss, NM; Stack, MS; Westfall, SD | 1 |
Liu, S; Mills, GB; Murph, M; Panupinthu, N | 1 |
Anantharamaiah, GM; Fogelman, AM; Hama, S; Hough, G; Imaizumi, S; Navab, M; Reddy, ST | 1 |
Bourgoin, SG; Chun, J; Fernandes, MJ; Poubelle, PE; Sardella, A; Zhao, C | 1 |
Murakami, M; Sato, H; Taketomi, Y; Yamamoto, K | 1 |
Berdyshev, E; Chun, J; He, D; Natarajan, V; Su, Y; Zhao, J; Zhao, Y | 1 |
Awada, R; Bourdon, E; Grès, S; Lefebvre d'Hellencourt, C; Rondeau, P; Saulnier-Blache, JS | 1 |
Balys, M; Chapman, TJ; Emo, J; Georas, SN; Meednu, N; Randall, T; Rangasamy, T; Rezaee, F | 1 |
Adamski, J; Berg, K; Björkbacka, H; Edsfeldt, A; Gonçalves, I; Grufman, H; Ko, NY; Nilsson, J; Nilsson, M; Nitulescu, M; Persson, A; Prehn, C | 1 |
Natarajan, V; Zhao, Y | 1 |
Crombie, D; Currie, PD; Ellett, F; Frisca, F; Goldshmit, Y; Lieschke, GJ; Matteo, R; Moreno, K; Pébay, A; Sabbadini, RA; Sztal, T | 1 |
Aidinis, V; Kaffe, E; Mouratis, MA; Sevastou, I | 1 |
Hayashi, Y; Inoue, K; Nakanishi, H; Peters, C; Sun, L; Tsuda, M; Wu, Z | 1 |
Czimmerer, Z; Nagy, L; Nemet, I; Poliska, S; Szanto, A; Varga, T | 1 |
Biessen, EA; Bot, I; Bot, M; de Jager, SC; Heeren, RM; Kuiper, J; Lagraauw, HM; MacAleese, L; Quax, PH; van Berkel, TJ | 1 |
Brown, JH; Cho, MK; Dusaban, SS; Masliah, E; Purcell, NH; Rockenstein, E; Smrcka, AV | 1 |
Cummings, R; Garcia, JG; He, D; Jacoby, D; Natarajan, V; Ohba, M; Saatian, B; Spannhake, EW; Watkins, T; Zhao, Y | 1 |
Chikumi, H; Kadowaki, S; Sato, K; Shimizu, E; Yamamoto, H; Yamasaki, A; Yoneda, K | 1 |
Bhagat, A; Kuypers, FA; Larkin, SK; Neidlinger, NA; Victorino, GP | 1 |
Barbaz, D; Bard, H; Bkaily, G; Brault, S; Checchin, D; Chemtob, S; Chorvatova, A; D'Orléans-Juste, P; Fortier, A; Geha, A; Gobeil, F; Goetzl, EJ; Gratton, JP; Heveker, N; Hou, X; Nader, M; Peri, K; Ribeiro-da-Silva, A; Vazquez-Tello, A; Zhu, T | 1 |
Barekzi, E; Georas, S; Hise, K; Roman, J; Steinke, JW | 1 |
Malbon, CC; Shumay, E; Tao, J; Wang, HY | 1 |
Baldini, PM; Carotenuto, F; Chiurchiu', V; D'Aquilio, F; Di Nardo, P; Giambra, V; Izzi, V; Procaccini, M | 1 |
Genetos, DC; Karin, NJ; Tan, R; Verma, S; Waters, KM; Yellowley, CE | 1 |
Chang, KJ; Chen, CN; Hsieh, FJ; Lee, H; Lin, CI; Lin, PW | 1 |
18 review(s) available for lysophosphatidic acid and Innate Inflammatory Response
Article | Year |
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Emerging Roles of Lysophosphatidic Acid in Macrophages and Inflammatory Diseases.
Topics: Humans; Inflammation; Lysophospholipids; Macrophages; Receptors, Lysophosphatidic Acid | 2023 |
Systems Pathology of Neuropathic Pain and Fibromyalgia.
Topics: Animals; Chronic Pain; Fibromyalgia; Inflammation; Lysophospholipids; Mice; Neuralgia; Receptors, Lysophosphatidic Acid; Signal Transduction | 2019 |
Roles for lysophosphatidic acid signaling in vascular development and disease.
Topics: Cardiovascular Diseases; Humans; Inflammation; Lysophospholipids; Molecular Structure; Muscle, Smooth, Vascular; Phosphatidate Phosphatase; Signal Transduction | 2020 |
Signalling by lysophosphatidate and its health implications.
Topics: Animals; Cardiovascular Diseases; Female; Humans; Idiopathic Pulmonary Fibrosis; Inflammation; Lysophospholipids; Neoplasms; Phosphatidate Phosphatase; Phosphoric Diester Hydrolases; Pregnancy; Pregnancy Complications; Receptors, G-Protein-Coupled; Signal Transduction; Wound Healing | 2020 |
Lysophosphatidic Acid Is an Inflammatory Lipid Exploited by Cancers for Immune Evasion
Topics: Animals; CD8-Positive T-Lymphocytes; CTLA-4 Antigen; Humans; Inflammation; Lysophospholipids; Neoplasm Proteins; Neoplasms; Programmed Cell Death 1 Receptor; Receptors, Lysophosphatidic Acid; Signal Transduction; Tumor Escape | 2020 |
The importance of blood platelet lipid signaling in thrombosis and in sepsis.
Topics: Animals; Blood Platelets; Humans; Inflammation; Lipid Metabolism; Lysophospholipids; Phosphatidylinositol 3-Kinases; Signal Transduction; Sphingosine; Thrombosis; Type C Phospholipases | 2018 |
Lysophosphatidate Signaling: The Tumor Microenvironment's New Nemesis.
Topics: Drug Resistance, Neoplasm; Humans; Inflammation; Lysophospholipids; Multienzyme Complexes; Mutation; Neoplasms; Phosphodiesterase I; Signal Transduction; Tumor Microenvironment | 2017 |
Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development.
Topics: Humans; Inflammation; Lysophospholipids; Neoplasms; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid; Signal Transduction | 2017 |
Regulatory Functions of Phospholipase A2.
Topics: Animals; Arachidonic Acid; Dietary Fats; Eicosanoids; Gene Expression Regulation, Enzymologic; Humans; Inflammation; Isoenzymes; Lysophospholipids; Phospholipases A2, Calcium-Independent; Phospholipases A2, Cytosolic; Phospholipases A2, Secretory; Phospholipids; Protein Conformation; Receptors, Phospholipase A2; Signal Transduction | 2017 |
The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation.
Topics: Adaptive Immunity; Airway Remodeling; Animals; Antigens; Asthma; Cell Movement; Chemotaxis, Leukocyte; Dendritic Cells; Humans; Inflammation; Isoxazoles; Lymphoid Tissue; Lysophospholipids; Mice; Phosphoric Diester Hydrolases; Propionates; Radiation Chimera; Receptors, Lysophosphatidic Acid; Signal Transduction; T-Lymphocytes; Up-Regulation; Venules | 2014 |
The structure/function of apoprotein A-I mimetic peptides: an update.
Topics: Anti-Inflammatory Agents; Antioxidants; Apolipoprotein A-I; Atherosclerosis; Biomimetic Materials; Diet; Female; Humans; Inflammation; Intestine, Small; Lysophospholipids; Male; Plants, Genetically Modified; Solanum lycopersicum; Structure-Activity Relationship | 2014 |
Polyunsaturated lysophosphatidic acid as a potential asthma biomarker.
Topics: Adult; Airway Remodeling; Allergens; Animals; Asthma; Biomarkers; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Humans; Inflammation; Lung; Lysophosphatidylcholines; Lysophospholipids; Mice; Phospholipases A1; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid | 2016 |
[Lysophospholipid mediators].
Topics: Animals; Cell Physiological Phenomena; Drug Design; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Insulin; Insulin Secretion; Lysophospholipids; Neurotransmitter Agents; Propylene Glycols; Receptors, G-Protein-Coupled; Sphingosine | 2009 |
Microenvironmental regulation of ovarian cancer metastasis.
Topics: Ascites; Cadherins; Carcinoma; Cell Adhesion; Cell Dedifferentiation; Cell Differentiation; Cell Transformation, Neoplastic; Cytokines; Epithelial Cells; Extracellular Matrix; Female; Fibroblasts; Humans; Inflammation; Integrins; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Neoplasm Proteins; Ovarian Neoplasms; Peptide Hydrolases; Peritoneal Neoplasms; Phenotype | 2009 |
ATX-LPA receptor axis in inflammation and cancer.
Topics: Animals; Breast Neoplasms; Female; Inflammation; Lysophospholipids; Mice; Mice, Transgenic; Models, Biological; Multienzyme Complexes; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Receptors, Lysophosphatidic Acid; Signal Transduction | 2009 |
Secreted phospholipase A2 revisited.
Topics: Animals; Arthritis; Catalysis; Glycerophospholipids; Group II Phospholipases A2; Heart Injuries; Humans; Inflammation; Lysophospholipids; Metabolic Syndrome; Mice; Neoplasms; Phospholipases A2; Phospholipids; Respiratory Distress Syndrome; Signal Transduction | 2011 |
Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling.
Topics: Airway Remodeling; Animals; Humans; Inflammation; Lung; Lysophospholipids; Receptors, Lysophosphatidic Acid | 2013 |
Lysoglycerophospholipids in chronic inflammatory disorders: the PLA(2)/LPC and ATX/LPA axes.
Topics: Animals; Chronic Disease; Humans; Inflammation; Lysophosphatidylcholines; Lysophospholipids; Phospholipases A2; Phosphoric Diester Hydrolases; Signal Transduction | 2013 |
1 trial(s) available for lysophosphatidic acid and Innate Inflammatory Response
Article | Year |
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Impairment of lysophospholipid metabolism in obesity: altered plasma profile and desensitization to the modulatory properties of n-3 polyunsaturated fatty acids in a randomized controlled trial.
Topics: Adult; Diet, High-Fat; Dietary Fats; Fatty Acids, Omega-3; Fatty Liver; Female; Hep G2 Cells; Humans; Inflammation; Insulin Resistance; Lysophospholipids; Male; Middle Aged; Obesity | 2016 |
52 other study(ies) available for lysophosphatidic acid and Innate Inflammatory Response
Article | Year |
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Mesenteric Adipose Tissue Contributes to Intestinal Fibrosis in Crohn's Disease Through the ATX-LPA Axis.
Topics: Adipose Tissue; Animals; Colon; Crohn Disease; Fibrosis; Inflammation; Lysophospholipids; Mice | 2022 |
GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway.
Topics: Acyltransferases; Humans; Inflammation; Kupffer Cells; Liver; Liver Diseases; Lysophospholipids; Protein Kinases; Signal Transduction | 2023 |
Lysophosphatidic Acid Induces Podocyte Pyroptosis in Diabetic Nephropathy by an Increase of Egr1 Expression via Downregulation of EzH2.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Down-Regulation; Early Growth Response Protein 1; Enhancer of Zeste Homolog 2 Protein; Histones; Inflammasomes; Inflammation; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Podocytes; Pyroptosis | 2023 |
MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia.
Topics: Animals; Inflammation; Lysophospholipids; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Microglia; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid | 2020 |
Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1
Topics: Animals; Colitis; CX3C Chemokine Receptor 1; Dextran Sulfate; Gastrointestinal Microbiome; Gene Deletion; Homeostasis; Humans; Inflammation; Inflammatory Bowel Diseases; Intestines; Lysophospholipids; Macrophages; Mice, Inbred C57BL; Phosphoric Diester Hydrolases; Receptors, G-Protein-Coupled; Signal Transduction; Tumor Necrosis Factor-alpha; Zebrafish; Zebrafish Proteins | 2020 |
Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis.
Topics: Adolescent; Adult; Aged; Animals; Cell Polarity; Central Nervous System; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Inflammation; Lysophospholipids; Macrophage Activation; Macrophages; Mice, Inbred C57BL; Middle Aged; Monocytes; Multiple Sclerosis; Phenotype; PPAR gamma; Receptors, Lysophosphatidic Acid; Recurrence; Young Adult | 2021 |
Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction.
Topics: Animals; Benzoxazoles; Cell Count; Cell Movement; Female; Gene Deletion; Humans; Inflammation; Interferon-alpha; Interferon-beta; Lysophospholipids; Macrophages; Male; Mice, Inbred C57BL; Middle Aged; Myelopoiesis; Myocardial Infarction; Myocardium; Phosphatidate Phosphatase; Phosphoric Diester Hydrolases; Piperazines; Recovery of Function; Up-Regulation; Vascular Remodeling; Wound Healing | 2020 |
Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling.
Topics: Animals; Blotting, Western; Cell Line; Cell Survival; Chemokine CCL2; Curcumin; Humans; Inflammation; Lysophospholipids; Muscle, Smooth, Vascular; Receptors, Transforming Growth Factor beta; rho-Associated Kinases; Signal Transduction | 2021 |
Lysophosphatidic Acid Protects Against Endotoxin-Induced Acute Kidney Injury.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Cytokines; Endotoxins; Inflammation; Lipopolysaccharides; Lysophospholipids; Mice; Mice, Inbred C57BL; Protective Agents; RAW 264.7 Cells | 2017 |
Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents.
Topics: Analgesics; Animals; Benzoxazoles; Cells, Cultured; Cyclic AMP; Female; Hyperalgesia; Inflammation; Injections, Spinal; Isoquinolines; Lysophospholipids; Male; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Pain; Pain Threshold; Piperidines; Polyisoprenyl Phosphates; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Lysophosphatidic Acid | 2017 |
Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress.
Topics: Animals; Chromatography, High Pressure Liquid; Fatty Acids; Humans; Inflammation; Isoprostanes; Lysophospholipids; Male; Metabolome; Metabolomics; Mice, Inbred C57BL; Nitrosative Stress; Oxidative Stress; Tandem Mass Spectrometry | 2018 |
Lysophosphatidic acid enhances neointimal hyperplasia following vascular injury through modulating proliferation, autophagy, inflammation and oxidative stress.
Topics: Animals; Atherosclerosis; Cell Proliferation; Hyperplasia; Inflammation; Lysophospholipids; Male; Neointima; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2018 |
In vitro evaluation of lysophosphatidic acid delivery via reverse perfluorocarbon emulsions to enhance alveolar epithelial repair.
Topics: Alveolar Epithelial Cells; Animals; Anti-Bacterial Agents; Cell Movement; Cell Proliferation; Cells, Cultured; Drug Delivery Systems; Emulsions; Fluorocarbons; Inflammation; Lysophospholipids; Mice; Particle Size; Surface Properties | 2018 |
Dexamethasone decreases the autotaxin-lysophosphatidate-inflammatory axis in adipose tissue: implications for the metabolic syndrome and breast cancer.
Topics: Adipose Tissue; Animals; Dexamethasone; Female; Humans; Inflammation; Lysophospholipids; Mammary Neoplasms, Experimental; Metabolic Syndrome; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Phosphoric Diester Hydrolases; Signal Transduction | 2019 |
Lysophosphatidic acid and its receptor LPA
Topics: Animals; Carrageenan; Facial Pain; Inflammation; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Pain; Receptors, Lysophosphatidic Acid; Signal Transduction | 2018 |
Autotaxin determines colitis severity in mice and is secreted by B cells in the colon.
Topics: Animals; B-Lymphocytes; Cell Line, Tumor; Cell Movement; Colitis; Colon; HCT116 Cells; Humans; Inflammation; Lymphocytes; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid; Signal Transduction | 2019 |
Adipose-derived autotaxin regulates inflammation and steatosis associated with diet-induced obesity.
Topics: Adipocytes; Adipose Tissue; Adiposity; Animals; Diet, High-Fat; Dietary Fats; Inflammation; Lysophospholipids; Mice; Mice, Inbred C57BL; Obesity; Phosphoric Diester Hydrolases; Triglycerides | 2019 |
Autotaxin-Lysophosphatidic Acid Axis Blockade Improves Inflammation by Regulating Th17 Cell Differentiation in DSS-Induced Chronic Colitis Mice.
Topics: Animals; Cell Differentiation; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Enzyme Inhibitors; Inflammation; Lysophospholipids; Mice; Phosphoric Diester Hydrolases; Th17 Cells | 2019 |
Lysophosphatidic acid and cardiovascular disease: seeing is believing.
Topics: Animals; Inflammation; Lysophospholipids; Mast Cells; Plaque, Atherosclerotic | 2013 |
Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation.
Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Humans; Inflammation; Lysophospholipids; Male; Mice; Mice, Transgenic; Phosphoric Diester Hydrolases; Signal Transduction | 2013 |
Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid.
Topics: Animals; Apolipoprotein A-I; Diet; Dyslipidemias; Female; Gene Expression Regulation; Inflammation; Intestine, Small; Lysophospholipids; Mice; Peptidomimetics; Plants, Genetically Modified; Receptors, LDL; Solanum lycopersicum; Western World | 2013 |
Allergic to autotaxin. A new role for lysophospholipase d and lysophosphatidic Acid in asthma?
Topics: Animals; Asthma; Humans; Inflammation; Lysophospholipids; Male; Phosphoric Diester Hydrolases | 2013 |
Mice with targeted inactivation of ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability.
Topics: Animals; Capillary Permeability; Cytokines; Endothelial Cells; Genotype; Hematopoietic Stem Cells; Inflammation; Inflammation Mediators; Integrases; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Phosphatidate Phosphatase; Phosphoric Diester Hydrolases; Promoter Regions, Genetic; Receptor, TIE-2; Receptors, Lysophosphatidic Acid; Signal Transduction; Transgenes | 2014 |
Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin.
Topics: Animals; Blood Cells; Cell Membrane; Chromatography, Liquid; Hypersensitivity; Inflammation; Lysophospholipids; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Phosphoric Diester Hydrolases; Protein Binding; Pruritus; Skin; Solubility; Sphingosine | 2014 |
A Major Human Oral Lysophosphatidic Acid Species, LPA 18:1, Regulates Novel Genes in Human Gingival Fibroblasts.
Topics: Adult; Cells, Cultured; Female; Fibroblasts; Gene Expression Regulation; Gingiva; Gingival Crevicular Fluid; Humans; Inflammation; Inflammation Mediators; Interleukin-11; Interleukin-6; Interleukin-8; Lysophospholipids; Male; Phosphoric Diester Hydrolases; Saliva; Signal Transduction; Suppressor of Cytokine Signaling Proteins; Transcription, Genetic | 2015 |
Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate.
Topics: Adipose Tissue; Animals; Carbolines; Gene Expression Regulation; Humans; Inflammation; Lysophospholipids; Mice; Phosphoric Diester Hydrolases; Receptors, G-Protein-Coupled; Sphingosine; Tumor Necrosis Factor-alpha; Wound Healing | 2015 |
A transgenic mouse model for the in vivo bioluminescence imaging of the expression of the lysophosphatidic acid receptor 3: relevance for inflammation and uterine physiology research.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Fluorescent Antibody Technique, Indirect; Humans; Image Processing, Computer-Assisted; Inflammation; Luciferases; Luminescent Measurements; Lysophospholipids; Male; Mice; Mice, Transgenic; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation; Uterus | 2015 |
Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation.
Topics: Actin Cytoskeleton; Animals; Annexin A1; Apoptosis; Cells, Cultured; Enzyme Activation; Humans; Inflammation; Lipopolysaccharide Receptors; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phospholipases A2, Calcium-Independent; Receptors, Formyl Peptide; Receptors, IgG; Receptors, Lysophosphatidic Acid; RNA Interference; RNA, Small Interfering; Zymosan | 2015 |
Lysophosphatidic acid generation by pulmonary NKT cell ENPP-2/autotaxin exacerbates hyperoxic lung injury.
Topics: Acute Lung Injury; Animals; Cell Count; Hyperoxia; Inflammation; Lung; Lysophosphatidylcholines; Lysophospholipids; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; Oxygen; Phosphoric Diester Hydrolases; Receptors, Purinergic P2X7; Up-Regulation | 2015 |
Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cytokines; Disease Models, Animal; Doxycycline; Female; Humans; Inflammation; Inflammation Mediators; Lysophospholipids; Macrophages; Mice; Neovascularization, Pathologic; NF-kappa B; Phosphorylation; Protein Transport; Tumor Burden; Xenograft Model Antitumor Assays | 2017 |
Phospholipid localization implies microglial morphology and function via Cdc42 in vitro.
Topics: Animals; Animals, Newborn; cdc42 GTP-Binding Protein; Cell Membrane; Cells, Cultured; Inflammation; Lysophospholipids; Mice, Knockout; Microglia; NF-kappa B; Phenotype | 2017 |
Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions.
Topics: Animals; Cell Communication; Cell Movement; Cells, Cultured; Chemokine CCL21; Chemokine CXCL13; Chronic Disease; Cytoskeleton; Endothelial Cells; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Inflammation; Lymph Nodes; Lymphocytes; Lysophospholipids; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Myeloid Differentiation Factor 88; Peyer's Patches; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Receptors, Lysophosphatidic Acid; Signal Transduction; Up-Regulation | 2008 |
Intestine may be a major site of action for the apoA-I mimetic peptide 4F whether administered subcutaneously or orally.
Topics: Administration, Cutaneous; Administration, Oral; Amino Acid Sequence; Animals; Apolipoprotein A-I; Apolipoproteins E; Atherosclerosis; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Feces; Female; Gene Deletion; Inflammation; Intestinal Mucosa; Lipoproteins, HDL; Liver; Lysophospholipids; Mice; Mice, Knockout; Molecular Mimicry; Molecular Sequence Data; Peptides; Serum Amyloid A Protein | 2011 |
TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines.
Topics: Animals; Chemokines; Dose-Response Relationship, Drug; Female; Gene Knockout Techniques; Inflammation; Leukocytes; Ligands; Lysophospholipids; Mice; Organothiophosphates; Phosphatidic Acids; Receptors, Interleukin-8B; Receptors, Lysophosphatidic Acid; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs.
Topics: Animals; Bronchi; Bronchoalveolar Lavage Fluid; Cells, Cultured; Epithelial Cells; Gene Expression Regulation; Inflammation; Interleukin-6; Interleukin-8; Isoxazoles; Lipopolysaccharide Receptors; Lipopolysaccharides; Lysophospholipids; Male; Membrane Microdomains; Mice; Mice, Knockout; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Propionates; Pulmonary Alveoli; Receptor Cross-Talk; Receptors, Lysophosphatidic Acid; Signal Transduction | 2011 |
Autotaxin protects microglial cells against oxidative stress.
Topics: Animals; Catalase; Cytoprotection; Gene Expression; Hydrogen Peroxide; Inflammation; Lysophospholipids; Mice; Microglia; Nitric Oxide Synthase Type II; Oxidants; Oxidation-Reduction; Oxidative Stress; Phosphoric Diester Hydrolases; Proteasome Endopeptidase Complex; Protein Carbonylation; Recombinant Proteins; Superoxide Dismutase | 2012 |
Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.
Topics: Administration, Inhalation; Adoptive Transfer; Allergens; Animals; Asthma; Dendritic Cells; Disease Models, Animal; Female; Gene Deletion; HEK293 Cells; Humans; Inflammation; Lung; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Receptors, Lysophosphatidic Acid; Signal Transduction; Transcription, Genetic | 2012 |
Evidence supporting a key role of Lp-PLA2-generated lysophosphatidylcholine in human atherosclerotic plaque inflammation.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Aged; Biomarkers; Biopsy; Carotid Stenosis; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Inflammation; Inflammation Mediators; Lysophosphatidylcholines; Lysophospholipids; Macrophages; Male; Mass Spectrometry; Middle Aged; Muscle, Smooth, Vascular; Phospholipases A2; Plaque, Atherosclerotic; Severity of Illness Index; T-Lymphocytes | 2012 |
Blockage of lysophosphatidic acid signaling improves spinal cord injury outcomes.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Cell Death; Cell Proliferation; Cell Survival; CHO Cells; Cricetinae; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Lysophospholipids; Mice; Microglia; Motor Activity; Neurites; Neuroprotective Agents; Receptors, Lysophosphatidic Acid; Recovery of Function; Signal Transduction; Spinal Cord Injuries; Zebrafish | 2012 |
Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain.
Topics: Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Analysis of Variance; Animals; Calcium-Binding Proteins; Carrier Proteins; Cathepsin B; CD11b Antigen; CD4 Antigens; Cells, Cultured; Chromogranin A; Chronic Pain; Cyclooxygenase 2; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Freund's Adjuvant; Functional Laterality; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Inflammation; Interleukin-18; Interleukin-1beta; Lysophospholipids; Lysosomes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microglia; Motor Activity; Nerve Tissue Proteins; NLR Family, Pyrin Domain-Containing 3 Protein; Pain Threshold; RNA, Small Interfering; Spinal Cord; Transfection | 2012 |
Identification of novel markers of alternative activation and potential endogenous PPARγ ligand production mechanisms in human IL-4 stimulated differentiating macrophages.
Topics: Adaptor Proteins, Signal Transducing; Antigens, CD; Arachidonate 15-Lipoxygenase; Biomarkers; Cell Differentiation; Cells, Cultured; Gene Expression; Gene Expression Profiling; Humans; Hydroxyeicosatetraenoic Acids; Inflammation; Interferon-gamma; Interleukin-4; Ligands; Linoleic Acids; Lipid Metabolism; Lysophospholipids; Macrophage Activation; Macrophages; Membrane Proteins; Monoamine Oxidase; Phosphoric Diester Hydrolases; PPAR gamma; Proto-Oncogene Proteins pp60(c-src); Reactive Oxygen Species; Transcription Factors; Transcriptional Activation; Tumor Necrosis Factor-alpha | 2012 |
Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation.
Topics: Animals; Apoptosis; Carotid Arteries; Cells, Cultured; Cromolyn Sodium; Inflammation; Lysophospholipids; Macrophages; Mast Cells; Mice; Plaque, Atherosclerotic; Radiography; Tryptases | 2013 |
Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses.
Topics: Animals; Astrocytes; Cyclooxygenase 2; Enzyme Activation; Inflammation; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; NF-kappa B; Phosphoinositide Phospholipase C; Protein Kinase C; Receptors, G-Protein-Coupled; Sphingosine; Thrombin; Wound Healing | 2013 |
Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells.
Topics: Acetophenones; Active Transport, Cell Nucleus; Animals; Benzopyrans; Blotting, Western; Bronchoalveolar Lavage; Cell Nucleus; Cells, Cultured; Chemokine CXCL2; Chemokines; Cytokines; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Humans; Inflammation; Interleukin-8; Luciferases; Lysophospholipids; Macrophages; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; NF-kappa B; Oligonucleotide Array Sequence Analysis; Phosphorylation; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Receptor, Platelet-Derived Growth Factor beta; RNA; Signal Transduction; Time Factors; Transcriptional Activation; Transfection | 2004 |
Down-regulation of inducible nitric oxide synthase by lysophosphatidic acid in human respiratory epithelial cells.
Topics: Cell Line; Cytokines; Down-Regulation; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Inflammation; Lysophospholipids; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Regeneration; Respiratory System; rho GTP-Binding Proteins; Signal Transduction | 2004 |
Hydrolysis of phosphatidylserine-exposing red blood cells by secretory phospholipase A2 generates lysophosphatidic acid and results in vascular dysfunction.
Topics: Animals; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Erythrocytes; Group II Phospholipases A2; Hemolysis; Humans; Hydrolysis; Inflammation; Lipids; Lysophospholipids; Palmitates; Phosphatidic Acids; Phosphatidylserines; Phospholipases A; Phospholipases A2; Phosphoserine; Rats; Time Factors; Umbilical Veins | 2006 |
Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1.
Topics: Animals; Base Sequence; Cell Nucleus; Cells, Cultured; DNA Primers; Gene Expression; Genes, Immediate-Early; Guanylate Cyclase; Humans; Inflammation; Liver; Lysophospholipids; Microscopy, Confocal; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Soluble Guanylyl Cyclase; Swine | 2006 |
Lysophosphatidic acid stimulates inflammatory cascade in airway epithelial cells.
Topics: Cell Proliferation; Cells, Cultured; Chemokines; Cytokines; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Gene Expression Regulation; Humans; Inflammation; Lung; Lysophospholipids; Nasal Mucosa; Nasal Polyps; Receptors, Lysophosphatidic Acid | 2006 |
Lysophosphatidic acid regulates trafficking of beta2-adrenergic receptors: the Galpha13/p115RhoGEF/JNK pathway stimulates receptor internalization.
Topics: Cell Line, Tumor; Cell Membrane; Genes, Dominant; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; Humans; Inflammation; Lysophospholipids; MAP Kinase Kinase 4; Microscopy, Confocal; Models, Biological; Protein Transport; Receptors, Adrenergic, beta-2; Rho Guanine Nucleotide Exchange Factors; rhoA GTP-Binding Protein; Signal Transduction | 2007 |
Activatory properties of lysophosphatidic acid on human THP-1 cells.
Topics: Arachidonic Acid; Cell Line; Cell Proliferation; Dinoprostone; DNA Replication; Enzyme Activation; Humans; Inflammation; Inflammation Mediators; Isoxazoles; Leukotriene B4; Lysophospholipids; Monocytes; NADPH Oxidases; Propionates; Reactive Oxygen Species; Receptors, Lysophosphatidic Acid; RNA, Messenger; Time Factors; Up-Regulation | 2007 |
DNA microarray analysis reveals a role for lysophosphatidic acid in the regulation of anti-inflammatory genes in MC3T3-E1 cells.
Topics: 3T3 Cells; Animals; Base Sequence; DNA Primers; Gene Expression Regulation; Inflammation; Kinetics; Lysophospholipids; Mice; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction | 2007 |
Lysophosphatidic acid regulates inflammation-related genes in human endothelial cells through LPA1 and LPA3.
Topics: Cell Adhesion; Cells, Cultured; Chemokine CCL2; Endothelial Cells; Gene Expression Regulation; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-1; Interleukin-8; Lysophospholipids; Peptide Fragments; Receptors, Lysophosphatidic Acid; RNA, Small Interfering | 2007 |