lysophosphatidic acid and Disease Exacerbation

Topics: AMP-Activated Protein Kinases; Cell Transformation, Neoplastic; Chemokine CXCL1; Cyclin D1; Cyclooxygenase 2; Cytoskeletal Proteins; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukins; Lysophospholipids; Ovarian Neoplasms; Peptide Fragments; Receptors, Lysophosphatidic Acid; Signal Transduction; Urokinase-Type Plasminogen Activator; Vascular Endothelial Growth Factor A

Topics: Animals; Arachidonic Acid; Cyclooxygenase 2; Disease Progression; Endocannabinoids; Genetic Predisposition to Disease; Humans; Lipid Metabolism; Lysophospholipids; Melanoma; Metabolic Networks and Pathways; Phosphatidylinositol 3-Kinases; Phospholipases; Phosphoric Diester Hydrolases; Prenylation; Prostaglandins; Receptors, Lysophosphatidic Acid; Signal Transduction

Topics: Animals; Cell Transformation, Neoplastic; Disease Progression; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Signal Transduction

Topics: Animals; Breast Neoplasms; Cell Transformation, Neoplastic; Disease Progression; Female; Humans; Lysophospholipids; Mice; Models, Biological; Multienzyme Complexes; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Receptors, Lysophosphatidic Acid; Signal Transduction

Topics: Animals; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Male; Mice; Multienzyme Complexes; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Phosphatidate Phosphatase; Phosphodiesterase I; Phospholipase D; Phosphoric Diester Hydrolases; Pyrophosphatases; Signal Transduction; Sphingosine

Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Cell Hypoxia; Chemokines; Cytokines; Disease Progression; Extracellular Matrix; Fibroblasts; Humans; Incidence; Intercellular Signaling Peptides and Proteins; Kallikrein-Kinin System; Kidney; Kidney Failure, Chronic; Lysophospholipids; Macrophages; Mice; Models, Biological; Morbidity; Myoblasts; Nephritis, Interstitial; Proteinuria; Renin-Angiotensin System

Topics: Blood Platelets; Bone and Bones; Breast Neoplasms; Cell Line, Tumor; Disease Progression; Female; Humans; Lysophospholipids; Models, Biological; Neoplasm Metastasis; Neovascularization, Pathologic; Osteolysis; Ovarian Neoplasms

Topics: Disease Progression; Drug Delivery Systems; Lysophospholipids; Neoplasms; Signal Transduction; Sphingosine; Treatment Outcome

Topics: Biomarkers; Disease Progression; Humans; Idiopathic Pulmonary Fibrosis; Lysophospholipids

Topics: Aged; Biomarkers; Disease Progression; Female; Humans; Logistic Models; Lysophospholipids; Male; Middle Aged; Proportional Hazards Models; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Severity of Illness Index

Topics: Animals; Biomarkers, Tumor; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Female; Gene Expression Regulation, Neoplastic; GTP-Binding Proteins; Humans; Immunohistochemistry; Lysophospholipids; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; Signal Transduction

Topics: Animals; Cell Line, Tumor; Cell Lineage; Cell Movement; Cell Proliferation; Disease Progression; Esophageal Squamous Cell Carcinoma; Heterografts; Humans; Lysophospholipids; Mice; Phosphoric Diester Hydrolases; Proto-Oncogene Proteins c-akt; Receptors, Lysophosphatidic Acid

Topics: Animals; Cell Line, Tumor; Disease Progression; Eukaryotic Initiation Factor-2; Humans; Lymphangiogenesis; Lymphatic Metastasis; Lysophospholipids; Male; Mice; Mice, Nude; Neoplasm Transplantation; Phosphoric Diester Hydrolases; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Receptors, Lysophosphatidic Acid; Signal Transduction; Vascular Endothelial Growth Factor C

Topics: Animals; Aortic Valve; Aortic Valve Stenosis; Apolipoprotein B-100; Blood Platelets; Calcinosis; Disease Progression; Humans; Integrin beta3; Lysophospholipids; Mice; Microscopy, Electron, Scanning; Osteogenesis; Phosphoric Diester Hydrolases; Platelet Membrane Glycoprotein IIb

Topics: Breast Neoplasms; Cell Line, Tumor; Cell Migration Assays; Cell Movement; Disease Progression; Epidermal Growth Factor; Female; Humans; Lysophospholipids; Neoplasm Metastasis; Phenotype; Tumor Stem Cell Assay

Topics: Animals; Atherosclerosis; Cell Movement; Cells, Cultured; Diabetes Mellitus; Diet, High-Fat; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Group VI Phospholipases A2; Hydrogen Peroxide; Lysophospholipids; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 4; NADPH Oxidases; Oligonucleotides, Antisense; Receptors, LDL; Signal Transduction; Stress, Physiological; Time Factors; Transfection; Up-Regulation

Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cystadenocarcinoma, Serous; Disease Progression; Dose-Response Relationship, Drug; Female; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Phosphoproteins; RNA Interference; Signal Transduction; Transcription Factors; Transcription, Genetic; YAP-Signaling Proteins

Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Disease Progression; Extracellular Matrix; Heterografts; Humans; Lysophospholipids; Male; Neoplasm Invasiveness; NF-kappa B; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; rhoA GTP-Binding Protein; Signal Transduction

Topics: Animals; Cell Line; Diabetes Mellitus; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Glycogen Synthase Kinase 3 beta; Isoxazoles; Kidney Cortex; Lysophospholipids; Male; Mice, Inbred C57BL; Phosphoric Diester Hydrolases; Phosphorylation; Propionates; Receptors, Lysophosphatidic Acid; RNA Interference; Signal Transduction; Smad2 Protein; Smad3 Protein; Sterol Regulatory Element Binding Protein 1; Time Factors; Transfection; Transforming Growth Factor beta

Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Movement; Cell Proliferation; Cisplatin; Disease Progression; Drug Therapy, Combination; Humans; Lysophospholipids; Matrix Metalloproteinase 2; Pancreatic Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tumor Cells, Cultured

Topics: Acyltransferases; Animals; Atherosclerosis; Carotid Arteries; Diet; Disease Progression; Gene Expression Profiling; Group VI Phospholipases A2; Homeostasis; Humans; Lysophospholipids; Male; Mice; Mice, Knockout; Molecular Sequence Data; Receptors, LDL

Topics: Actins; Carcinoma, Hepatocellular; Cell Differentiation; Disease Progression; Fibroblasts; Humans; Liver Neoplasms; Lysophospholipids; Myofibroblasts; Phosphoric Diester Hydrolases

Topics: Adherens Junctions; Caco-2 Cells; Cell Movement; Colonic Neoplasms; Disease Progression; Focal Adhesion Kinase 1; Focal Adhesions; Humans; Lysophospholipids; Phenotype; Protein Kinases; Proto-Oncogene Proteins pp60(c-src); rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Stress Fibers

Topics: Antigens, CD; Cell Line, Tumor; Disease Progression; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits, G12-G13; Guanosine Triphosphate; Humans; Lysophospholipids; Male; Neoplasm Invasiveness; Neoplasm Metastasis; Prostatic Neoplasms; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein; Signal Transduction

Topics: Animals; Aorta, Thoracic; Apolipoproteins E; Arteriosclerosis; Cell Movement; Disease Progression; Endothelium, Vascular; Female; Kinetics; Lipids; Lysophospholipids; Male; Mice; Mice, Knockout; Monocytes; Platelet Activating Factor; Transplantation, Homologous

Topics: Animals; Cattle; Chromatography, Thin Layer; Disease Progression; Dose-Response Relationship, Drug; Egg White; Lysophospholipids; Mass Spectrometry; Models, Chemical; Phosphates; Plant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Wound Healing; Zinc

Topics: Animals; Blood Platelets; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cricetinae; Culture Media; Cytokines; Disease Progression; Dose-Response Relationship, Drug; Doxycycline; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Interleukin-6; Interleukin-8; Ki-67 Antigen; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogens; Models, Biological; Neoplasm Metastasis; Osteoclasts; Osteolysis; Phospholipase D; Platelet Activation; Platelet Aggregation; Reverse Transcriptase Polymerase Chain Reaction; RNA; Time Factors; Transfection

Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytokines; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Lysophospholipids; Mice; Neoplasm Metastasis; Osteoclasts; Propionates; Receptors, Lysophosphatidic Acid

Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Disease Progression; Diterpenes; Dose-Response Relationship, Drug; Female; Humans; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; Ovarian Neoplasms; Phosphorylation; ras Proteins; Time Factors; Xenograft Model Antitumor Assays