lysophosphatidic acid has been researched along with Cirrhosis in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 16 (47.06) | 24.3611 |
| 2020's | 10 (29.41) | 2.80 |
| Authors | Studies |
|---|---|
| Aoki, J; Hla, T; Kano, K | 1 |
| Guo, F; Guo, Z; Huang, L; Li, Y; Qian, W; Xu, Y; Yin, Y; Zhu, W | 1 |
| Jun, HS; Kim, D; Nam, GY; Seo, E | 1 |
| Cheon, J; Jun, HS; Kim, D; Lee, GH | 1 |
| Aihara, M; Ali, H; Azuma, M; Has, RY; Kagawa, K; Kawano, H; Koyama, K; Morito, K; Nishioka, Y; Takahashi, N; Tanaka, T | 1 |
| Nakamura, Y; Shimizu, Y | 1 |
| Kajiyama, H; Kakinuma, H; Kamigaso, S; Kobayashi, Y; Kuroda, S; Matsuda, D; Nakano, K; Naruse, T; Okumura-Kitajima, L; Toki, H; Tokura, S; Uneuchi, F; Wada, R; Yamagishi, J; Yonemoto, Y | 1 |
| Bauer, Y; Birker-Robaczewska, M; Boucher, M; Freti, D; Gatfield, J; Klenk, A; Menyhart, K; Nayler, O; Renault, B; Schnoebelen, M; Studer, R; Zmajkovicova, K | 1 |
| Hirata, T; Miyata, N; Roman, RJ; Smith, SV; Takahashi, T | 1 |
| Eivers, SB; O'Brien, CJ; O'Regan, A | 1 |
| Ding, W; Li, H; Liu, XY; Sun, W; Sun, XJ; You-Zhuan, X; Zhang, K; Zhao, CQ; Zhao, J | 1 |
| Ben-Mrad, M; El Meddeb Hamrouni, A; Espenel, S; Guy, JB; Langrand-Escure, J; Magné, N; Rancoule, C; Rehailia-Blanchard, A; Trone, JC; Vallard, A; Xia, Y | 1 |
| Brandan, E; Contreras, O; Riquelme-Guzmán, C | 1 |
| Bascands, JL; Bouloumié, A; Decaunes, P; Gres, S; Langin, D; Rancoule, C; Saulnier-Blache, JS; Valet, P; Viaud, M; Viguerie, N | 1 |
| Adams, JS; Ba, K; Bogdanov, J; Crooks, GM; Evseenko, D; Lee, S; Lin, Y; McAllister, DR; Petrigliano, FA; Rosenthal, AK; Van Handel, B; Wu, L | 1 |
| Bain, G; Black, KE; Castelino, FV; George, L; Goulet, L; Lafyatis, R; Pace, VA; Probst, CK; Tager, AM | 1 |
| Davies, MR; Feeley, BT; Kim, HT; Lee, L; Liu, X | 1 |
| Baïotto, A; Bascands, JL; Bertrand-Michel, J; Denis, C; Dupuy, A; Klein, J; Marsal, D; Mirzoyan, K; Saulnier-Blache, JS; Schanstra, JP; Sicard, P; Vinel, C | 1 |
| Dowling, MR; Rosethorne, EM; Sattikar, A | 1 |
| Aoki, J; Emoto, S; Igarashi, K; Ikeda, H; Kano, K; Kitayama, J; Kurano, M; Matsusaki, K; Nishikawa, M; Yamashita, H; Yatomi, Y | 1 |
| Ashby, P; Brophy, CM; Flynn, CR; Furnish, EJ; Hansen, A; Komalavilas, P; Longaker, MT; Lopes, LB; Ly, DP; Panitch, A; Yang, GP | 1 |
| Jenkins, G; Knox, AJ; Maher, TM; McAnulty, RJ; Porte, J; Sheppard, D; Violette, SM; Weinreb, PH; Xu, MY | 1 |
| Choi, JW; Chun, J; Herr, DR; Lee, CW; Lin, ME; Mosley, AN; Mutoh, T; Noguchi, K; Park, KE; Teo, ST; Yung, YC | 1 |
| Pattanaik, D; Postlethwaite, AE | 1 |
| Bascands, JL; Gonzalez, J; Klein, J; Pradère, JP; Rancoule, C; Saulnier-Blache, JS; Schanstra, JP; Valet, P | 1 |
| Shimizu, Y; Tokumura, A | 1 |
| Dubois, G; Pyne, NJ; Pyne, S | 1 |
| Geng, H; Gilchrist, A; Lan, R; Saikumar, P; Singha, PK; Venkatachalam, MA; Violette, SM; Weinberg, JM; Weinreb, PH | 1 |
| Atilla, G; Black, SA; Emingil, G; Firatli, E; Hasturk, H; Kantarci, A; Lee, A; Murawel, P; Sheff, M; Trackman, PC; Uchida, Y; Uzel, MI; Van Dyke, TE; Xydas, CE; Yucekal-Tuncer, B | 1 |
| Asari, S; Chiba, A; Fujita, K; Fukuchi, N; Iida, Y; Ijichi, C; Iwayama, S; Kataba, Y; Ohmuta, N; Ohsumi, K; Shoji, M; Yamamoto, T | 1 |
| Bascands, JL; Calise, D; Chun, J; Grès, S; Guigné, C; Klein, J; Neau, E; Pradère, JP; Saulnier-Blache, JS; Schanstra, JP; Valet, P | 1 |
| Tong, Y; Watsky, MA; Yin, Z; Zhu, H | 1 |
| Ley, K; Zarbock, A | 1 |
| Bascands, JL; Gonzalez, J; Grès, S; Klein, J; Pradère, JP; Salant, D; Saulnier-Blache, JS; Schanstra, JP; Valet, P | 1 |
10 review(s) available for lysophosphatidic acid and Cirrhosis
| Article | Year |
|---|---|
Lysophospholipid Mediators in Health and Disease.
Topics: Animals; Female; Fibrosis; Humans; Lysophospholipids; Neoplasms; Signal Transduction | 2022 |
Cellular and Molecular Control of Lipid Metabolism in Idiopathic Pulmonary Fibrosis: Clinical Application of the Lysophosphatidic Acid Pathway.
Topics: Endothelial Cells; Fibrosis; Humans; Idiopathic Pulmonary Fibrosis; Lipid Metabolism; Lysophospholipids | 2023 |
The lysophosphatidic acid axis in fibrosis: Implications for glaucoma.
Topics: Fibrosis; Glaucoma; Humans; Lysophospholipids; Trabecular Meshwork; Wound Healing | 2021 |
Lysophosphatidic acid (LPA) as a pro-fibrotic and pro-oncogenic factor: a pivotal target to improve the radiotherapy therapeutic index.
Topics: Animals; Biomarkers; Cell Transformation, Neoplastic; Fibrosis; Humans; Lysophospholipids; Neoplasms; Radiation Tolerance; Radiation, Ionizing; Radiotherapy; Signal Transduction; Therapeutic Index | 2017 |
LPA receptors: subtypes and biological actions.
Topics: Animals; Cardiovascular Physiological Phenomena; Fibrosis; Humans; Immune System; Lysophospholipids; Neoplasms; Nervous System Physiological Phenomena; Obesity; Receptors, Lysophosphatidic Acid; Reproduction; Signal Transduction | 2010 |
A role for lysophosphatidic acid and sphingosine 1-phosphate in the pathogenesis of systemic sclerosis.
Topics: Autoimmunity; Blood Vessels; Fibrosis; Humans; Lysophospholipids; Scleroderma, Systemic; Sphingosine | 2010 |
Lysophosphatidic acid-1-receptor targeting agents for fibrosis.
Topics: Animals; Clinical Trials as Topic; Fibrosis; Humans; Lysophospholipids; Molecular Targeted Therapy; Receptors, Lysophosphatidic Acid | 2011 |
[Physiological role of lysophosphatidic acid and its relevancephysiological role of lysophosphatidic acid and its relevance to diseases].
Topics: Animals; Arteriosclerosis; Cell Transformation, Neoplastic; Fibrosis; Humans; Lysophospholipids; Receptors, Lysophosphatidic Acid | 2011 |
Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis.
Topics: Animals; Fibrosis; Humans; Lysophospholipids; Models, Biological; Organ Specificity; Receptors, Lysosphingolipid; Sphingosine | 2013 |
Lysophosphatidic acid and renal fibrosis.
Topics: Animals; Fibrosis; Humans; Kidney Diseases; Lysophospholipids; Models, Biological; Receptors, Lysophosphatidic Acid | 2008 |
1 trial(s) available for lysophosphatidic acid and Cirrhosis
| Article | Year |
|---|---|
Pro-fibrotic activity of lysophosphatidic acid in adipose tissue: in vivo and in vitro evidence.
Topics: Actins; Adipose Tissue; Animals; Collagen; Enzyme Activators; Female; Fibrosis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Isoxazoles; Lysophospholipids; Male; Mice; Mice, Obese; Propionates; Receptors, Lysophosphatidic Acid; Tissue Culture Techniques; Transforming Growth Factor beta | 2014 |
23 other study(ies) available for lysophosphatidic acid and Cirrhosis
| Article | Year |
|---|---|
Mesenteric Adipose Tissue Contributes to Intestinal Fibrosis in Crohn's Disease Through the ATX-LPA Axis.
Topics: Adipose Tissue; Animals; Colon; Crohn Disease; Fibrosis; Inflammation; Lysophospholipids; Mice | 2022 |
Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Diabetic Nephropathies; Down-Regulation; Female; Fibronectins; Fibrosis; Lysophospholipids; Male; Mesangial Cells; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; TNF Receptor-Associated Factor 4; Transforming Growth Factor beta; Ubiquitin-Protein Ligases; Ubiquitination | 2022 |
Lysophosphatidic Acid Promotes Epithelial-Mesenchymal Transition in Kidney Epithelial Cells via the LPAR1/MAPK-AKT/KLF5 Signaling Pathway in Diabetic Nephropathy.
Topics: Actins; Animals; Cadherins; Diabetic Nephropathies; Epithelial Cells; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Factor V; Fibronectins; Fibrosis; Glycerophospholipids; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Kidney Tubules; Kruppel-Like Transcription Factors; Lysophospholipids; Mice; Propionates; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Transcription Factors; Vimentin | 2022 |
Lysophosphatidic acid, ceramide 1-phosphate and sphingosine 1-phosphate in peripheral blood of patients with idiopathic pulmonary fibrosis.
Topics: Ceramides; Fibrosis; Humans; Idiopathic Pulmonary Fibrosis; Lysophospholipids; Sphingosine | 2022 |
Lead generation from N-[benzyl(4-phenylbutyl)carbamoyl]amino acid as a novel LPA
Topics: Amino Acids; Animals; Fibrosis; Lysophospholipids; Mice; Scleroderma, Systemic | 2023 |
GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1.
Topics: Cell Cycle Proteins; Cell Line; Enzyme Activation; Fibroblasts; Fibrosis; Humans; Ligands; Lysophospholipids; Receptors, G-Protein-Coupled; rho-Associated Kinases; Signal Transduction; Smad2 Protein; Sphingosine-1-Phosphate Receptors; Thrombin; Transcription Factors; Transforming Growth Factor beta1 | 2020 |
Increased Levels of Renal Lysophosphatidic Acid in Rodent Models with Renal Disease.
Topics: Animals; Diabetic Nephropathies; Fibrosis; Hypertension, Renal; Isoxazoles; Kidney; Lysophospholipids; Male; Propionates; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley | 2021 |
Hypertrophy and Fibrosis of the Ligamentum Flavum in Lumbar Spinal Stenosis is Associated With Increased Expression of LPA and LPAR1.
Topics: Adult; Aged; Aged, 80 and over; Connective Tissue Growth Factor; Female; Fibrosis; Humans; Hypertrophy; Ligamentum Flavum; Lysophospholipids; Magnetic Resonance Imaging; Male; Middle Aged; Receptors, Lysophosphatidic Acid; Spinal Stenosis; Statistics as Topic; Young Adult | 2017 |
Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin/FAK axis.
Topics: Animals; Cell Differentiation; Cell Line; Connective Tissue Growth Factor; Disease Models, Animal; Extracellular Matrix; Fibroblasts; Fibrosis; Focal Adhesion Kinase 1; Integrin alphaV; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Myoblasts; Phosphorylation; Signal Transduction | 2018 |
Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis.
Topics: Animals; Cartilage, Articular; Collagen Type I; Fibrosis; Humans; Lysophospholipids; Male; Rats; Rats, Sprague-Dawley; Stifle | 2015 |
An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis.
Topics: Animals; Benzoates; Bleomycin; Case-Control Studies; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Fibrosis; Humans; Immunohistochemistry; Interleukin-6; Lysophospholipids; Mice; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Real-Time Polymerase Chain Reaction; RNA, Small Interfering; Scleroderma, Systemic; Skin | 2016 |
Lysophosphatidic acid-induced RhoA signaling and prolonged macrophage infiltration worsens fibrosis and fatty infiltration following rotator cuff tears.
Topics: Animals; Disease Models, Animal; Female; Fibrosis; Lysophospholipids; Macrophages; Muscular Atrophy; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Rotator Cuff; Rotator Cuff Injuries | 2017 |
Increased urinary lysophosphatidic acid in mouse with subtotal nephrectomy: potential involvement in chronic kidney disease.
Topics: Albuminuria; Animals; Disease Models, Animal; Down-Regulation; Female; Fibrosis; Gene Expression; Kidney; Lysophospholipids; Mice; Nephrectomy; Nephritis, Interstitial; Nerve Tissue Proteins; Phosphatidate Phosphatase; Phosphorylation; Renal Insufficiency, Chronic | 2016 |
Endogenous lysophosphatidic acid (LPA
Topics: Calcium; Cells, Cultured; Fibroblasts; Fibrosis; Humans; Ligands; Lung; Lysophospholipids; MAP Kinase Signaling System; Neoplasms; Receptors, Lysophosphatidic Acid; Signal Transduction | 2017 |
Analysis of glycero-lysophospholipids in gastric cancerous ascites.
Topics: Animals; Ascites; Female; Fibrosis; Humans; Lysophospholipids; Male; Mice; Phospholipases A1; Phosphoric Diester Hydrolases; Stomach Neoplasms | 2017 |
Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts.
Topics: 14-3-3 Proteins; Animals; Collagen Type I; Connective Tissue Growth Factor; Cricetinae; Endothelins; Fibroblasts; Fibrosis; Heat-Shock Proteins, Small; HSP20 Heat-Shock Proteins; Humans; Keloid; Lysophospholipids; Phodopus; Phosphoproteins; Phosphorylation; Transforming Growth Factor beta1 | 2009 |
Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).
Topics: Animals; Antigens, Neoplasm; Blotting, Western; Coculture Techniques; Fibrosis; Flow Cytometry; Fluorescent Antibody Technique; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Immunohistochemistry; Integrins; Lung; Lung Injury; Lysophospholipids; Mice; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Transforming Growth Factor beta | 2009 |
Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β.
Topics: Animals; Antigens, Neoplasm; Cell Nucleus; Connective Tissue Growth Factor; Cytokines; Fibrosis; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Integrins; Kidney Tubules, Proximal; Lipids; Lysophospholipids; Male; Mice; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Receptors, Lysophosphatidic Acid; Regeneration; Reperfusion Injury; rho GTP-Binding Proteins; RNA, Messenger; Signal Transduction; Smad2 Protein; Time Factors; Transforming Growth Factor beta | 2012 |
Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis.
Topics: Adult; Cells, Cultured; Connective Tissue Cells; Connective Tissue Growth Factor; Epithelial Cells; Fibroblasts; Fibromatosis, Gingival; Fibrosis; Gingiva; Humans; Immediate-Early Proteins; Immunohistochemistry; In Situ Hybridization; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Transforming Growth Factor beta | 2006 |
Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists.
Topics: Animals; Cell Proliferation; Chemistry, Pharmaceutical; CHO Cells; Cricetinae; Cricetulus; Drug Design; Fibrosis; Humans; Inhibitory Concentration 50; Isoxazoles; Liver; Lysophospholipids; Propionates; Rats | 2007 |
LPA1 receptor activation promotes renal interstitial fibrosis.
Topics: Animals; Culture Media, Conditioned; Fibrosis; Humans; Isoxazoles; Kidney; Kidney Diseases; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phospholipids; Propionates; Receptors, Lysophosphatidic Acid; Transforming Growth Factor beta; Ureter | 2007 |
ClC-3 is required for LPA-activated Cl- current activity and fibroblast-to-myofibroblast differentiation.
Topics: Actins; Cell Differentiation; Cell Line; Cell Size; Chloride Channels; Chlorides; Down-Regulation; Fibroblasts; Fibrosis; Flow Cytometry; Humans; Keratinocytes; Lysophospholipids; Membrane Potentials; Myocytes, Smooth Muscle; Patch-Clamp Techniques; RNA Interference; Transforming Growth Factor beta1; Wound Healing | 2008 |
From lung injury to fibrosis.
Topics: Animals; Fibroblasts; Fibrosis; Humans; Lung; Lung Diseases; Lung Injury; Lysophospholipids; Macrophages; Models, Biological; Pulmonary Alveoli; Pulmonary Fibrosis; Receptors, Lysophosphatidic Acid | 2008 |