lysophosphatidic acid has been researched along with Cancer of Ovary in 150 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 78 (52.00) | 29.6817 |
| 2010's | 60 (40.00) | 24.3611 |
| 2020's | 12 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, T; Liu, Y; Pan, Y; Tang, Y; Tian, M | 1 |
| Damirin, A; Li, A; Li, R; Sun, H; Wang, Y; Yan, Y; Yun, Q; Zhao, P | 1 |
| Song, M; Suh, PG | 1 |
| Awasthi, D; Barrat, FJ; Casado, J; Chae, CS; Chaudhary, V; Cubillos-Ruiz, JR; D'Andrea, AD; Emmanuelli, A; Färkkilä, A; Giovanelli, P; Holcomb, K; Hwang, SM; Kossenkov, AV; Park, ES; Pépin, D; Romero-Sandoval, EA; Salvagno, C; Sandoval, TA; Song, M; Tan, C; Zamarin, D | 1 |
| Feng, B; Huang, X; Li, S; Liu, M; Liu, Z; Zeng, W | 1 |
| Conejo-Garcia, JR; Curiel, TJ | 1 |
| De La Franier, B; Thompson, M | 1 |
| Bos, B; Campbell, L; Kim, O; Klymenko, Y; Liu, Y; Loughran, E; Stack, MS; Yang, J | 1 |
| Ji, C; Kuckling, D; Li, J; Lü, B; Paradies, J; Rodin, M; Yin, M | 1 |
| Bai, H; Cao, G; Cui, R; Zhang, Z | 1 |
| Fang, X; He, T; Ma, Y; Mukherjee, A; Wang, W; Wang, XY; Wu, J | 1 |
| Cho, KH; Jeong, BY; Lee, HY; Park, CG; Park, HW; Yoon, SH | 1 |
| Ai, K; Jia, Y; Li, Z; Liu, J; Lu, L; Lu, Z; Pei, H; Wang, Y | 1 |
| Bailey, KA; Feist, PE; Hummon, AB; Klymenko, Y; Schultz, ZD; Stack, MS | 1 |
| Daniel, LW; Davis, RR; Hollis, T; Rogers, LC; Said, N | 1 |
| Dhanasekaran, DN; Fung, KM; Ha, JH; Isidoro, C; Jayaraman, M; Moxley, K; Mukherjee, P; Radhakrishnan, R; Song, YS; Sood, AK; Ward, JD; Yan, M | 1 |
| Catane, LJ; Davidson, B; Hetland Falkenthal, TE; Onallah, H; Reich, R; Tropé, CG | 1 |
| Asafova, A; Brandt, DT; Finkernagel, F; Graumann, J; Grosse, R; Jansen, JM; Konzer, A; Lieber, S; Müller, R; Müller-Brüsselbach, S; Nist, A; Nockher, WA; Pesek, J; Reinartz, S; Stiewe, T; Wagner, U; Watzer, B; Worzfeld, T | 1 |
| Dhanasekaran, DN; Ha, JH; Isidoro, C; Jayaraman, M; Liu, J; Moxley, KM; Radhakrishnan, R; Song, YS; Sood, AK | 1 |
| Franier, B; Thompson, M | 1 |
| Chantome, A; Fontaine, D; Garcia, C; Goupille, C; Kouba, S; Ouldamer, L; Potier-Cartereau, M; Vandier, C | 1 |
| Heo, SC; Jeong, GO; Kim, JH; Kim, KH; Kwon, YW; Seo, EJ; Shin, SH; Suh, DS; Yoon, MS | 1 |
| Fukushima, N; Iwamori, M; Izuka, N; Kumamoto, S; Kuwata, S; Murota, K; Ohkubo, K; Tsujiuchi, T; Yamaguchi, N | 1 |
| Dhanasekaran, DN; Ha, JH; Kim, SG; Varadarajalu, L; Ward, JD | 1 |
| Cho, YK; Hwang, H; Kim, EK; Park, J; Suh, PG | 1 |
| Cecerska, E; Dolegowska, B; Jesionowska, A | 1 |
| Chen, Y; Hu, C; Hu, Z; Lu, Z | 1 |
| Dhanasekaran, DN; Ha, JH; Jayaraman, M; Ward, JD | 1 |
| Lynch, KR; Nakayama, J; Raines, TA; Slack-Davis, JK | 1 |
| Chen, H; Yu, X; Zhang, Y | 1 |
| Fan, LM; Li, YY; Yu, HM; Zhang, JL; Zhang, WC; Zheng, CJ; Zhu, H | 1 |
| Burkhalter, RJ; Liu, Y; Stack, MS; Westfall, SD | 1 |
| Cai, Q; Fan, Q; Xu, Y | 1 |
| Cheng, P; Shi, W; Zaworotko, MJ; Zhang, SY | 1 |
| Cecerska-Heryc, E; Dolegowska, B; Jesionowska, A; Matoszka, N | 1 |
| Carolan, A; Ellerbroek, SM; Farley, J; Gardner, N; Henningsen, M; Heying, E; Huegel, K; Kobliska, A; Kotecki, A; Lizalek, J; Lundt, A; Marsh, S; McKenna, T; Miller, G | 1 |
| Beedle, AM; Jia, W; Kennedy, EJ; Murph, MM; Nguyen, HT | 1 |
| Cao, L; Dong, L; Fan, L; Fu, Z; Li, Y; Meng, W; Yang, S; Zhang, J; Zhang, W; Zhang, Y; Zheng, C; Zhu, H | 1 |
| Berrios, E; Fang, X; Fang, Z; Gong, Y; Ma, Y; Mohamed, EM; Mukherjee, A; Shao, H; Yuan, F | 1 |
| Aoki, J; Choi, EJ; Choi, KU; Jang, IH; Kim, DK; Kim, JH; Kim, KH; Kim, KP; Kwon, YW; Lee, JH; Lee, JW; Lee, SI; Matsumoto, H; Mok, HJ; Seo, EJ; Suh, DS | 1 |
| Lin, Z; Wu, J; Yao, D | 1 |
| Dhanasekaran, DN; Ha, JH; Jayaraman, M; Radhakrishnan, R; Song, YS; Ward, JD | 1 |
| Dhanasekaran, DN; Gomathinayagam, R; Ha, JH; Husain, S; Jayaraman, M; Liu, J; Mukherjee, P; Reddy, EP; Song, YS; Yan, M | 1 |
| Chowdhury, SR; Ray, U; Roy, SS | 1 |
| Bankar, K; Ray, U; Roy Chowdhury, S; Roy, SS; Roychoudhury, S; Vasudevan, M | 1 |
| Hsieh, CY; Huang, RY; Wang, SM; Wu, JC | 1 |
| Devine, KM; Fishman, DA; Hope, JM; Smicun, Y | 1 |
| Bigsby, RM; Caperell-Grant, A; Liu, J; Mok, SC; Wang, D; Xu, Y; Yang, G; Zhao, Z | 1 |
| Bae, SS; Birnbaum, MJ; Cho, M; Do, KH; Kim, CD; Kim, EK; Kim, JH; Kim, MS; Suh, DS; Yun, SJ | 1 |
| Bai, L; Cong, YS; Deng, X; Xu, Y; Yang, K; Zheng, D | 1 |
| Hanousek, L; Sedláková, I; Tosner, J; Vávrová, J | 3 |
| Choi, WS; Han, JW; Jeong, KJ; Kang, JK; Kim, YK; Lee, HY; Lee, KB; Park, CG; Park, SY; Seo, JH | 1 |
| Fang, X; Lee, Z; Mukherjee, A; Oyesanya, RA; Song, Y; Wu, J | 1 |
| Chen, CS; E, S; Fujiwara, Y; Guo, H; Kihara, A; Lai, YJ; Lin, FT; Tigyi, G; Tsukahara, R; Yu, JH; Yue, J | 1 |
| Børresen-Dale, AL; Hall, H; Helland, A; Hennessy, BT; Kristensen, G; Lahad, J; Liu, W; Lu, Y; Mills, GB; Murph, MM; Schaner, M; Yu, S | 1 |
| Kirmani, K; Li, H; Steinmetz, R; Wang, D; Xu, Y; Zhang, H; Zhao, Z | 1 |
| Cho, DY; Jeong, KJ; Kang, JK; Kim, YK; Lee, HY; Oh, WJ; Park, CG; Seo, JH; Sohn, JS; Sul, HJ | 1 |
| Rigó, J; Tanyi, J | 1 |
| Fishman, DA; Wang, F | 1 |
| Wang, D; Wang, Z; Xu, Y | 1 |
| Barbolina, MV; Burkhalter, RJ; Forgacs, G; Hudson, LG; Liu, Y; Marga, F; Moss, NM; Stack, MS; Westfall, SD | 1 |
| Barfield, E; Dutta, S; Fishman, DA; Pua, T; Wang, FQ | 1 |
| Meier, KE; Snider, AJ; Xie, Y; Zhang, Z | 1 |
| Hashimoto, K; Kawase, C; Kimura, T; Mabuchi, S; Morishige, K; Ogata, S; Ooyagi, C; Sakata, M; Sawada, K | 1 |
| Fishman, DA; Pua, TL; Wang, FQ | 1 |
| Choi, KU; Choi, YJ; Heo, SC; Jeon, ES; Kim, JH; Lee, IH; Park, DY; Park, JH; Suh, DS; Yoon, MS | 1 |
| Choi, KU; Choi, YJ; Heo, SC; Jeon, ES; Kim, JH; Lee, IH; Shin, SH; Suh, DS; Yoon, MS; Yun, JS | 1 |
| Belinson, JL; Ganapathi, R; Michener, CM; Sengupta, S; Vaziri, S; Wang, C | 1 |
| Dutta, S; Fishman, DA; Wang, FQ | 1 |
| Diamandis, EP | 1 |
| Daniel, LW; Klomsiri, C; Poole, LB; Rogers, LC; Saunders, JA | 1 |
| Hikita, S; Kuroki, M; Miyamoto, S; Tsujioka, H; Ueda, T; Yotsumoto, F | 1 |
| Amneus, MW; Anantharamaiah, GM; Farias-Eisner, G; Farias-Eisner, R; Fogelman, AM; Gao, F; Grijalva, V; Hough, G; Imaizumi, S; Kozak, KR; Navab, M; Ng, C; Reddy, ST; Su, F; Van Lenten, BJ; Wagner, A | 1 |
| Ali, MW; Altman, MK; Callihan, P; Hooks, SB; Hurst, JH; Murph, MM | 1 |
| Fisher, J; Fishman, DA; Wang, FQ | 1 |
| Chen, H; Huang, S; Pan, ZK; Wu, X | 1 |
| Anantharamaiah, GM; Chattopadhyay, A; Farias-Eisner, R; Fogelman, AM; Ganapathy, E; Gao, F; Grijalva, V; Imaizumi, S; Johnston, B; Meriwether, D; Navab, M; Reddy, ST; Roberts, S; Shah, N; Su, F; Vasquez, SX | 1 |
| Choi, JW; Kim, EK; Kim, HS; Kim, KT; Lee, DS; Lim, S; Oh, K; Park, JM; Ryu, SH; Seo, JK; Seok, H; Suh, PG | 1 |
| Dutta, S; Fishman, DA; Mukherjee, TJ; Wang, FQ; Wu, HS | 1 |
| Fang, X; Lebman, DA; Mukherjee, A; Wu, J | 1 |
| Altman, MK; Eneh, JO; Jia, W; Murph, MM; Ratnaparkhe, S | 1 |
| Cho, KH; Han, JW; Jeong, KJ; Kang, J; Kim, YK; Lee, HY; Lee, J; Park, CG; Park, SY; Sohn, JS | 1 |
| Chattopadhyay, A; Farias-Eisner, R; Fogelman, AM; Gao, F; Grijalva, V; Navab, M; Reddy, ST; Su, F | 1 |
| Chou, LY; Huang, RY; Liao, CK; Wang, SH; Wen, CC; Wu, JC | 1 |
| Barbour, S; Fang, X; Mukherjee, A; Wu, J | 1 |
| Boyon, C; D'Anjou, F; Day, R; Desmons, A; Farré, I; Fournier, I; Leblanc, E; Longuespée, R; Ly, K; Salzet, M; Vinatier, D; Wisztorski, M | 1 |
| Antalis, C; Cai, Q; Del Priore, G; Hamed, AH; Schilder, JM; Stehman, FB; Xu, Y; Yan, L; Zhao, Z | 1 |
| Cho, KH; Jeong, KJ; Kang, J; Kim, H; Lee, HY; Mills, GB; Panupinthu, N; Park, CG | 1 |
| Dong, Z; Korkina, O; Marullo, A; Ruggieri, R; Symons, M; Warshaw, G | 1 |
| Budnik, LT | 1 |
| Atkinson, EN; Bast, RC; Berchuck, A; Broaddus, R; Cheng, KW; Felix, EA; Fishman, D; Hartmann, LC; Hasegawa, Y; Kalli, K; Lapushin, R; Lu, K; McCune, K; Mills, GB; Morris, AJ; Newman, RA; Smith, DI; Tanyi, JL; Wolf, JK; Yamal, JM | 1 |
| Aggarwal, BB; Bast, RC; Claret, FX; Fang, X; Hu, SX; LaPushin, R; Liu, S; Lu, Y; Mills, GB; Xu, HJ; Yu, S | 1 |
| Furui, T; Imai, A; Sugiyama, M; Tamaya, T | 1 |
| Bian, D; Cheng, RK; Han, Q; Huang, S; Mahanivong, C; Pan, ZK; Su, S; Sun, P | 1 |
| French, R; Nguyen, GH; Radhakrishna, H | 1 |
| Ha, KS; Han, JA; Jeoung, D; Kang, YC; Kim, KM; Kim, YM; Kwon, YG; Lee, KS; Lee, SJ; Namkoong, S | 1 |
| Hasuwa, H; Hirata, M; Kageyama, T; Kai, M; Kanoh, H; Mekada, E; Miyamoto, S; Mizushima, H; Nakano, H; Sonoda, K; Tanaka, Y; Yagi, H; Yamazaki, A | 1 |
| Chen, CA; Chou, CH; Hsieh, CY; Huang, YJ; Kuo, ML; Lai, KP; Wei, LH | 1 |
| Fishman, DA; Navari, J; So, J; Wang, FQ | 1 |
| Mekada, E; Miyamoto, S | 1 |
| Do, TV; Fishman, DA; Graves, L; Meng, Y; So, J | 1 |
| Gupta, GP; Massagué, J | 1 |
| Bian, D; Chun, J; Huang, S; Li, H; Mahanivong, C; Ye, X | 1 |
| Fishman, DA; Kang, S; Meng, Y; Reierstad, S; So, J | 1 |
| Fishman, DA; Kang, S; Meng, Y | 2 |
| Miyamoto, S; Tanaka, Y; Yagi, H | 1 |
| Hashimoto, K; Morishige, K; Murata, Y; Sakata, M; Sawada, K; Shimizu, S; Tahara, M; Tasaka, K | 1 |
| Adley, BP; Auersperg, N; Hudson, LG; Stack, MS; Symowicz, J; Woo, MM | 1 |
| Fishman, DA; Navari, J; Schreher, J; So, J; Wang, FQ | 1 |
| Braun, AH; Coffey, RJ | 1 |
| Martyn, KD; Park, DJ; Warn-Cramer, BJ | 1 |
| Alejandro, E; Kamrava, M; Kohn, EC; Meltzer, E; Michener, C; Simpkins, F | 1 |
| Seballos, L; Sutphen, R; Zhang, JZ | 1 |
| Berk, M; Jiang, Y; Powell, CT; Singh, LS; Tan, H; Xu, Y; Yin, L | 1 |
| Bian, D; Frisch, SM; Huang, S; Mahanivong, C; Pan, ZK; Ye, RD; Yu, J | 1 |
| Chen, WX; Guo, Q; Shan, BE; Wang, P; Wu, XH | 1 |
| Fishman, DA; Kang, S; Luo, R; Meng, Y; Smicun, Y | 1 |
| Bast, RC; Fang, X; Lee, Z; Liang, Y; Liu, S; Lu, KH; Mills, GB; Swaby, RF; Yu, S | 1 |
| Feng, L; Prestwich, GD; Ren, J; Rose, TM; Singh, LS; Xiao, YJ; Xu, Y; Zhao, X; Zhao, Z | 1 |
| Alptürk, O; Crowe, WE; Escobedo, JO; Fakayode, SO; Král, V; Pruet, JM; Rusin, O; Strongin, RM; Wang, W; Warner, IM | 1 |
| Feng, L; Lauber, K; Prestwich, G; Rose, TM; Sengupta, S; Shen, Y; Wang, D; Wesselborg, S; Xiao, Y; Xu, Y; Zhang, J; Zhang, R; Zhao, X; Zhao, Z | 1 |
| Belinson, J; Berk, M; Escobar, PF; Kim, KS; Kwak, YG; Mok, SC; Sengupta, S; Xu, Y | 1 |
| Calluzzo, N; Fishman, DA; Smicun, Y; Wang, FQ | 1 |
| Belinson, J; Berk, MP; Escobar, P; Kim, KS; Li, W; Lindner, DJ; Oates, R; Sengupta, S; Williams, B; Xu, Y | 1 |
| Berman, DM; Do, TV; Fishman, DA; Liotta, LA; Petricoin, EF; Stack, MS; Symowicz, JC | 1 |
| Fulton, DJ; Mok, SC; Motamed, K; Najwer, I; Said, NA; Socha, MJ | 1 |
| Hashimoto, K; Kimura, T; Morishige, K; Ogata, S; Sakata, M; Sawada, K; Shimizu, S; Tahara, M; Tasaka, K | 1 |
| Shi, L; Wang, H; Wu, XH | 1 |
| Aoki, J; Arai, H; Fukuzawa, K; Kanzaki, H; Kume, T; Tahara, M; Tasaka, K; Tokumura, A; Yasuda, K | 1 |
| Barbour, SE; Chen, J; Fang, X; Hu, W; Lee, Z; Murthy, KS; Oyesanya, R; Song, Y; Wilkins, P; Wu, J | 1 |
| Bermudez, Y; Cheng, JQ; Kruk, PA; Nicosia, SV; Saunders, BO; Yang, H | 1 |
| Claret, FX; Eder, AM; Estrella, VC; Gallick, GE; Liu, S; Mills, GB; Pustilnik, TB; Tabassam, FH; Wiener, JR | 1 |
| Devine, K; Fishman, DA; Gil, O; Smicun, Y | 1 |
| Chen, HM; Dong, Z; Huang, S; Mahanivong, C; Pan, ZK; Yee, SW | 1 |
| Meden-Vrtovec, H; Meleh, M; Mlakar, A; Pozlep, B; Zupancic-Kralj, L | 1 |
| Choi, WS; Han, JW; Jeong, KJ; Kim, BK; Kim, YK; Kim, YM; Lee, HY; Lee, J; Park, SY; Yoon, DS | 1 |
| Kobal, B; Kralj, LZ; Meden-Vrtovec, H; Meleh, M; Osredkar, J; Pozlep, B; Verdenik, I | 1 |
| Chang, CL; Cho, M; Jeon, ES; Kim, JH; Lee, JS; Lee, MJ; Suh, DS | 1 |
| Chang, CL; Cho, M; Jeon, ES; Jung, JS; Kim, JH; Kim, YM; Lee, MJ; Moon, HJ; Song, HY; Suh, DS; Yoon, MS | 1 |
| Ariztia, EV; Fishman, DA; Gil, OD; Hope, JM; Lee, C; Smith, PJ; Wang, FQ | 1 |
| Brown, AL; Henkel, PA; Hooks, SB; Hurst, JH | 1 |
| Davis, L; Jaffe, K; Li, S; Shan, L | 1 |
| Guo, RX; Li, LX; Qiao, YH; Wang, M; Zhang, JH; Zhang, MZ; Zhang, XY; Zhao, GQ; Zhao, XL; Zhou, W | 1 |
| Belinson, J; Escobar, P; Ganapathi, R; Michener, CM; Sengupta, S | 1 |
| Bandle, RW; Pendrak, ML; Ptaszynska, MM; Roberts, DD; Stracke, ML | 1 |
| Chen, J; Dent, P; Fang, X; Kordula, T; Lee, ZP; Mukherjee, A; Oyesanya, RA; Song, Y; Wu, J; Zhou, H | 1 |
| Du, XL; Wang, F; Wang, GL; Wang, ZY; Wen, ZQ; Xu, WP | 1 |
20 review(s) available for lysophosphatidic acid and Cancer of Ovary
| Article | Year |
|---|---|
Preclinical detection of lysophosphatidic acid: A new window for ovarian cancer diagnostics.
Topics: Biomarkers, Tumor; Carcinoma, Ovarian Epithelial; Female; Humans; Lysophospholipids; Ovarian Neoplasms | 2022 |
The Role of Lysophosphatidic Acid Receptors in Ovarian Cancer: A Minireview.
Topics: AMP-Activated Protein Kinases; Cell Transformation, Neoplastic; Chemokine CXCL1; Cyclin D1; Cyclooxygenase 2; Cytoskeletal Proteins; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukins; Lysophospholipids; Ovarian Neoplasms; Peptide Fragments; Receptors, Lysophosphatidic Acid; Signal Transduction; Urokinase-Type Plasminogen Activator; Vascular Endothelial Growth Factor A | 2020 |
Early stage detection and screening of ovarian cancer: A research opportunity and significant challenge for biosensor technology.
Topics: Animals; Biomarkers, Tumor; Biosensing Techniques; CA-125 Antigen; Chaperonin 10; Early Detection of Cancer; Female; Humans; Lysophospholipids; Ovarian Neoplasms | 2019 |
Lipid metabolism and Calcium signaling in epithelial ovarian cancer.
Topics: Animals; Arachidonic Acid; Calcium Signaling; Carcinogenesis; Epithelial Cells; Female; Humans; Lipid Metabolism; Lysophospholipids; Ovarian Neoplasms; Receptor Cross-Talk; Risk | 2019 |
Methods for quantifying lysophosphatidic acid in body fluids: a review.
Topics: Biomarkers, Tumor; Blood Chemical Analysis; Body Fluids; Carcinoma, Ovarian Epithelial; Colorimetry; Enzyme Assays; Enzyme-Linked Immunosorbent Assay; Fluorometry; Humans; Lysophospholipids; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms | 2014 |
Diagnostic value of total plasma lysophosphatidic acid in ovarian cancer: a meta-analysis.
Topics: Biomarkers, Tumor; Case-Control Studies; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Prognosis; ROC Curve | 2015 |
Plasma levels of lysophosphatidic acid in ovarian cancer versus controls: a meta-analysis.
Topics: Adult; Aged; Case-Control Studies; Female; Humans; Lysophospholipids; Middle Aged; Ovarian Neoplasms; Publication Bias | 2015 |
Lysophosphatidic acid signaling in ovarian cancer.
Topics: Female; Humans; Lysophospholipids; Ovarian Neoplasms; Signal Transduction | 2015 |
Diagnostic value of plasma lysophosphatidic acid levels in ovarian cancer patients: A case-control study and updated meta-analysis.
Topics: Adult; Aged; CA-125 Antigen; Case-Control Studies; Female; Humans; Lysophospholipids; Middle Aged; Ovarian Neoplasms; ROC Curve | 2015 |
[Lysophosphatidic acid as a potential target for treatment and molecular diagnosis of epithelial ovarian cancers].
Topics: Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors | 2009 |
Lysophosphatidic acid and invasion.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cyclooxygenase 2; Diterpenes; Female; Humans; Interleukins; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Membrane Lipids; Mice; Multienzyme Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; Ovarian Neoplasms; Peptide Hydrolases; Phosphodiesterase I; Phospholipases A; Phosphoric Diester Hydrolases; Pyrophosphatases; Receptors, Lysophosphatidic Acid; Signal Transduction; Sphingosine; Vascular Endothelial Growth Factor A | 2009 |
Lipid generation and signaling in ovarian cancer.
Topics: Antineoplastic Agents; Cell Hypoxia; Drug Delivery Systems; Female; Forecasting; Humans; Lysophospholipids; Multienzyme Complexes; Neoplasm Proteins; Ovarian Neoplasms; Phosphodiesterase I; Phospholipases A2; Phospholipases A2, Cytosolic; Phosphoric Diester Hydrolases; Pyrophosphatases; Receptors, Lysophosphatidic Acid; Signal Transduction; Sphingosine | 2009 |
Microenvironmental regulation of ovarian cancer metastasis.
Topics: Ascites; Cadherins; Carcinoma; Cell Adhesion; Cell Dedifferentiation; Cell Differentiation; Cell Transformation, Neoplastic; Cytokines; Epithelial Cells; Extracellular Matrix; Female; Fibroblasts; Humans; Inflammation; Integrins; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Neoplasm Proteins; Ovarian Neoplasms; Peptide Hydrolases; Peritoneal Neoplasms; Phenotype | 2009 |
Roles of LPA in ovarian cancer development and progression.
Topics: Animals; Cell Transformation, Neoplastic; Disease Progression; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Signal Transduction | 2009 |
Targeting the heparin-binding epidermal growth factor-like growth factor in ovarian cancer therapy.
Topics: Antineoplastic Agents; Bacterial Proteins; Cell Proliferation; Clinical Trials, Phase I as Topic; Epidermal Growth Factor; Female; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Ovarian Neoplasms; Protein Serine-Threonine Kinases; Signal Transduction | 2011 |
Ovarian cancer molecular pathology.
Topics: Animals; CA-125 Antigen; Cell Proliferation; Female; Humans; I-kappa B Kinase; Lysophospholipids; MAP Kinase Signaling System; Neoplasm Metastasis; NF-kappa B; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Proteomics; Receptors, Estrogen; Signal Transduction | 2012 |
[Biological behavior of ovarian cancer].
Topics: Ascitic Fluid; Calcium; Cell Division; Drug Design; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Signal Transduction | 2004 |
Platelets and metastasis revisited: a novel fatty link.
Topics: Blood Platelets; Bone and Bones; Breast Neoplasms; Cell Line, Tumor; Disease Progression; Female; Humans; Lysophospholipids; Models, Biological; Neoplasm Metastasis; Neovascularization, Pathologic; Osteolysis; Ovarian Neoplasms | 2004 |
[HB-EGF is a promising target molecule for ovarian cancer].
Topics: Animals; Antineoplastic Agents; Bacterial Proteins; Cell Division; Drug Design; Epidermal Growth Factor; ErbB Receptors; Female; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Lysophospholipids; Ovarian Neoplasms; Signal Transduction | 2004 |
Lysophosphatidic acid: friend or foe of the ovarian surface epithelium.
Topics: Biomarkers, Tumor; Biopsy, Needle; Connexin 43; Down-Regulation; Epithelium; Female; Humans; Immunohistochemistry; Lysophospholipids; Neoplasm Staging; Ovarian Neoplasms; Prognosis; Sensitivity and Specificity; Survival Analysis; Tumor Cells, Cultured | 2005 |
1 trial(s) available for lysophosphatidic acid and Cancer of Ovary
| Article | Year |
|---|---|
Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity.
Topics: Adult; Ascitic Fluid; Biomarkers, Tumor; Choline; Cystadenoma, Mucinous; Dermoid Cyst; Female; Humans; Lysophospholipids; Multienzyme Complexes; Ovarian Neoplasms; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases | 2007 |
129 other study(ies) available for lysophosphatidic acid and Cancer of Ovary
| Article | Year |
|---|---|
Amelioration of human peritoneal mesothelial cell co-culture-evoked malignant potential of ovarian cancer cells by acacetin involves LPA release-activated RAGE-PI3K/AKT signaling.
Topics: Apoptosis; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coculture Techniques; Epithelium; Female; Flavones; Humans; Lysophospholipids; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor for Advanced Glycation End Products; Signal Transduction | 2021 |
LPA3 is a precise therapeutic target and potential biomarker for ovarian cancer.
Topics: Animals; Biomarkers, Tumor; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Female; Gene Expression Regulation, Neoplastic; GTP-Binding Proteins; Humans; Immunohistochemistry; Lysophospholipids; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; Signal Transduction | 2022 |
O-GlcNAcylation regulates lysophosphatidic acid-induced cell migration by regulating ERM family proteins.
Topics: Acetylglucosamine; Apoptosis; Cell Line, Tumor; Cell Movement; Female; Humans; Lysophospholipids; Ovarian Neoplasms | 2022 |
Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer.
Topics: Female; Humans; Interferon Type I; Lysophospholipids; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; Tumor Microenvironment | 2022 |
Belly Fat Weakens Immune Fitness.
Topics: Abdominal Fat; Carcinoma, Ovarian Epithelial; Female; Humans; Interferon Type I; Lysophospholipids; Ovarian Neoplasms | 2022 |
Detection of the Ovarian Cancer Biomarker Lysophosphatidic Acid in Serum.
Topics: Biomarkers, Tumor; Female; Humans; Lysophospholipids; Ovarian Neoplasms | 2020 |
Lysophosphatidic acid modulates ovarian cancer multicellular aggregate assembly and metastatic dissemination.
Topics: Animals; Carcinoma, Ovarian Epithelial; Cell Adhesion; Cell Aggregation; Cell Line, Tumor; Epithelial Cells; Female; Humans; Lysophospholipids; Mice; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Microvilli; Ovarian Neoplasms; Peritoneal Neoplasms; Tumor Microenvironment | 2020 |
Dually Crosslinked Supramolecular Hydrogel for Cancer Biomarker Sensing.
Topics: beta-Cyclodextrins; Biomarkers, Tumor; Biosensing Techniques; Computer Simulation; Cross-Linking Reagents; Female; Humans; Hydrogels; Limit of Detection; Lysophospholipids; Molecular Conformation; Ovarian Neoplasms; Surface Plasmon Resonance | 2020 |
Lysophosphatidic acid induces tumor necrosis factor-alpha to regulate a pro-inflammatory cytokine network in ovarian cancer.
Topics: ADAM17 Protein; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-1beta; Interleukin-6; Interleukin-8; Lysophospholipids; Ovarian Neoplasms; Tumor Necrosis Factor-alpha | 2020 |
Discoidin Domain Receptor 2 Mediates Lysophosphatidic Acid-Induced Ovarian Cancer Aggressiveness.
Topics: Cell Line, Tumor; Discoidin Domain Receptor 2; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Phosphatidylinositol 3-Kinase; Signal Transduction; TOR Serine-Threonine Kinases | 2021 |
Synergistic Tailoring of Electrostatic and Hydrophobic Interactions for Rapid and Specific Recognition of Lysophosphatidic Acid, an Early-Stage Ovarian Cancer Biomarker.
Topics: Animals; Early Detection of Cancer; Equipment Design; Female; Humans; Hydrophobic and Hydrophilic Interactions; Lysophospholipids; Mice; Mice, Inbred C57BL; Ovarian Neoplasms; Ovary; Polyacetylene Polymer; Polymers; Polyynes; Reagent Strips; Static Electricity | 2017 |
Chemical Analysis of Morphological Changes in Lysophosphatidic Acid-Treated Ovarian Cancer Cells.
Topics: Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Female; Humans; Lysophospholipids; Ovarian Neoplasms | 2017 |
Blocking LPA-dependent signaling increases ovarian cancer cell death in response to chemotherapy.
Topics: Antioxidants; Apoptosis; Cell Death; Cell Line, Tumor; Cell Proliferation; Cisplatin; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Paclitaxel; Reactive Oxygen Species | 2018 |
LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Female; Glycolysis; Heterografts; Hexokinase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Mice; Mice, Nude; NADPH Oxidases; Ovarian Neoplasms; rac1 GTP-Binding Protein; Reactive Oxygen Species; Receptors, G-Protein-Coupled | 2018 |
Activity and clinical relevance of autotaxin and lysophosphatidic acid pathways in high-grade serous carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma; Disease-Free Survival; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Kaplan-Meier Estimate; Lysophospholipids; Middle Aged; Multivariate Analysis; Neoplasm Grading; Neoplasm Staging; Neoplasms, Cystic, Mucinous, and Serous; Ovarian Neoplasms; Phosphoric Diester Hydrolases; Phosphorylation; Proportional Hazards Models; Proto-Oncogene Proteins c-akt; Receptors, Lysophosphatidic Acid; Risk Factors; RNA, Messenger; Signal Transduction; Time Factors; Treatment Outcome | 2018 |
Cell type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.
Topics: Ascites; Cell Line, Tumor; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Macrophages; Metabolome; Neoplasms, Cystic, Mucinous, and Serous; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; Signal Transduction; Treatment Outcome; Tumor Microenvironment; Up-Regulation | 2019 |
Ovarian cancer cell-derived lysophosphatidic acid induces glycolytic shift and cancer-associated fibroblast-phenotype in normal and peritumoral fibroblasts.
Topics: Ascitic Fluid; Cancer-Associated Fibroblasts; Cell Differentiation; Cell Line, Tumor; Culture Media, Conditioned; Female; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Ovarian Neoplasms; Paracrine Communication; Phenotype; Receptors, Lysophosphatidic Acid; Signal Transduction | 2019 |
TAZ mediates lysophosphatidic acid-induced migration and proliferation of epithelial ovarian cancer cells.
Topics: Butadienes; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Isoxazoles; Lysophospholipids; Neoplasms, Glandular and Epithelial; Nitriles; Ovarian Neoplasms; Propionates; Protein Stability; Trans-Activators; Transcription Factors; Transcriptional Coactivator with PDZ-Binding Motif Proteins | 2013 |
Extracellular lipid metabolism influences the survival of ovarian cancer cells.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Fatty Acids; Female; Gene Expression Regulation, Neoplastic; Humans; Lipid Metabolism; Lysophospholipids; Ovarian Neoplasms; Ovary | 2013 |
The gep proto-oncogene Gα12 mediates LPA-stimulated activation of CREB in ovarian cancer cells.
Topics: Cell Line, Tumor; Cell Proliferation; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Female; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Lysophospholipids; Models, Biological; Mutant Proteins; Ovarian Neoplasms; Phosphorylation; Phosphoserine; Proto-Oncogene Mas; ras Proteins; Signal Transduction; Transcription Factors | 2014 |
RhoA and Rac1 play independent roles in lysophosphatidic acid-induced ovarian cancer chemotaxis.
Topics: ADP Ribose Transferases; Amides; Aminoquinolines; Botulinum Toxins; Cell Line, Tumor; Chemotaxis; Enzyme Inhibitors; Female; Guanine Nucleotide Exchange Factors; Humans; Lysophospholipids; Microfluidic Analytical Techniques; Ovarian Neoplasms; Pyridines; Pyrimidines; rac1 GTP-Binding Protein; rho-Associated Kinases; rhoA GTP-Binding Protein | 2014 |
LPA-mediated migration of ovarian cancer cells involves translocalization of Gαi2 to invadopodia and association with Src and β-pix.
Topics: Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Surface Extensions; Female; Focal Adhesions; GTP-Binding Protein alpha Subunit, Gi2; Humans; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Protein Transport; Rho Guanine Nucleotide Exchange Factors; src-Family Kinases; Tumor Cells, Cultured | 2015 |
Decreased peritoneal ovarian cancer growth in mice lacking expression of lipid phosphate phosphohydrolase 1.
Topics: Analysis of Variance; Animals; Cell Proliferation; Female; Gene Deletion; Immunohistochemistry; Lysophospholipids; Mice; Mice, Knockout; Nerve Tissue Proteins; Ovarian Neoplasms; Peritoneal Neoplasms; Tumor Microenvironment | 2015 |
[Lysophosphatidic acid (LPA) stimulates invasion and metastatic colonization of ovarian cancer cells through Rac activation].
Topics: Animals; Cell Movement; Female; Humans; Lysophospholipids; Mice; Ovarian Neoplasms; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Tumor Cells, Cultured | 2015 |
Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma.
Topics: Active Transport, Cell Nucleus; beta Catenin; Blotting, Western; Cadherins; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Integrin beta1; Lysophospholipids; Microscopy, Fluorescence; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Protein Binding; Proto-Oncogene Proteins; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; TCF Transcription Factors; Vimentin; Wnt Proteins; Wnt-5a Protein | 2015 |
FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cystadenocarcinoma, Serous; Disease Progression; Dose-Response Relationship, Drug; Female; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Phosphoproteins; RNA Interference; Signal Transduction; Transcription Factors; Transcription, Genetic; YAP-Signaling Proteins | 2015 |
A mixed-crystal lanthanide zeolite-like metal-organic framework as a fluorescent indicator for lysophosphatidic acid, a cancer biomarker.
Topics: Biomarkers, Tumor; Female; Fluorescent Dyes; Genital Neoplasms, Female; Humans; Lanthanoid Series Elements; Lysophospholipids; Molecular Structure; Organometallic Compounds; Ovarian Neoplasms; Zeolites | 2015 |
Lysophosphatidic Acid Stimulates Urokinase Receptor (uPAR/CD87) in Ovarian Epithelial Cancer Cells.
Topics: Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Female; Humans; Lysophospholipids; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Receptors, Urokinase Plasminogen Activator; Urokinase-Type Plasminogen Activator | 2015 |
Lysophosphatidic Acid Mediates Activating Transcription Factor 3 Expression Which Is a Target for Post-Transcriptional Silencing by miR-30c-2-3p.
Topics: 3' Untranslated Regions; Activating Transcription Factor 3; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Lysophospholipids; MicroRNAs; Microscopy, Fluorescence; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic | 2015 |
Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells.
Topics: Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Glycolysis; Hexokinase; Humans; Lysophospholipids; Ovarian Neoplasms; Up-Regulation | 2015 |
Autotaxin Regulates Maintenance of Ovarian Cancer Stem Cells through Lysophosphatidic Acid-Mediated Autocrine Mechanism.
Topics: Ataxin-1; Autocrine Communication; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Culture Media, Conditioned; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Neoplasms, Glandular and Epithelial; Neoplastic Stem Cells; Ovarian Neoplasms; Phosphoric Diester Hydrolases; Proto-Oncogene Proteins c-akt; Receptors, Lysophosphatidic Acid; Signal Transduction | 2016 |
Near-Infrared Fluorogenic Probes with Polarity-Sensitive Emission for in Vivo Imaging of an Ovarian Cancer Biomarker.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fluorescent Dyes; Humans; Integrin alphaVbeta3; Lysophospholipids; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Oligopeptides; Ovarian Neoplasms; Spectroscopy, Near-Infrared; Transplantation, Heterologous | 2016 |
Lysophosphatidic acid stimulates epithelial to mesenchymal transition marker Slug/Snail2 in ovarian cancer cells via Gαi2, Src, and HIF1α signaling nexus.
Topics: Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Ovarian Neoplasms; Snail Family Transcription Factors; src-Family Kinases | 2016 |
Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Heterografts; Humans; Lysophospholipids; Mice; Models, Biological; Ovarian Neoplasms; Protein Binding; Proto-Oncogene Proteins c-jun; Tumor Burden | 2016 |
Lysophosphatidic Acid Promotes Epithelial to Mesenchymal Transition in Ovarian Cancer Cells by Repressing SIRT1.
Topics: Cadherins; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Microscopy, Fluorescence; Ovarian Neoplasms; RNA Interference; RNA, Small Interfering; Sirtuin 1 | 2017 |
Gene regulatory networking reveals the molecular cue to lysophosphatidic acid-induced metabolic adaptations in ovarian cancer cells.
Topics: Adenocarcinoma; Animals; Cell Line, Tumor; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mitochondria; Neoplasm Invasiveness; Ovarian Neoplasms; Oxidative Phosphorylation; Phosphatidylinositol 3-Kinases; Proto-Oncogene Protein c-ets-1; Sequence Analysis, RNA | 2017 |
Lysophosphatidic acid induces ovarian cancer cell dispersal by activating Fyn kinase associated with p120-catenin.
Topics: Adherens Junctions; alpha Catenin; Catenins; Cell Adhesion Molecules; Cell Line, Tumor; Delta Catenin; Dose-Response Relationship, Drug; Enzyme Activation; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Phosphoproteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fyn; Pyrimidines; src-Family Kinases | 2008 |
S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac.
Topics: Antigens, CD; Cadherins; Cell Adhesion; Cell Line, Tumor; Female; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Ovarian Neoplasms; Pertussis Toxin; rac GTP-Binding Proteins; Sphingosine; Urokinase-Type Plasminogen Activator | 2008 |
S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells.
Topics: Ascites; Cell Line, Tumor; Cell Movement; Cell Shape; Enzyme Activation; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Lysophospholipids; Mitogen-Activated Protein Kinase Kinases; Ovarian Neoplasms; Protein Kinase C; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Stress Fibers | 2008 |
Lysophosphatidic acid induces cell migration through the selective activation of Akt1.
Topics: Adult; Aged; Animals; Ascites; Cell Movement; Cells, Cultured; Embryo, Mammalian; Enzyme Activation; Female; Humans; Liver Cirrhosis; Lysophospholipids; Mice; Middle Aged; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Pregnancy; Proto-Oncogene Proteins c-akt; Substrate Specificity | 2008 |
Lysophosphatidic acid activates telomerase in ovarian cancer cells through hypoxia-inducible factor-1alpha and the PI3K pathway.
Topics: Cell Line, Tumor; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; Telomerase | 2008 |
Lysophosphatidic acid: an ovarian cancer marker.
Topics: Adult; Biomarkers, Tumor; Female; Humans; Lysophospholipids; Middle Aged; Ovarian Neoplasms | 2008 |
Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells.
Topics: Butadienes; Cell Line, Tumor; Cell Movement; CSK Tyrosine-Protein Kinase; Cyclooxygenase 2; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Nitriles; Ovarian Neoplasms; Pertussis Toxin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrimidines; Quinazolines; Receptors, Lysophosphatidic Acid; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; src-Family Kinases; Transcriptional Activation; Tyrphostins | 2008 |
Sp-1 and c-Myc mediate lysophosphatidic acid-induced expression of vascular endothelial growth factor in ovarian cancer cells via a hypoxia-inducible factor-1-independent mechanism.
Topics: Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Models, Biological; Neovascularization, Pathologic; Ovarian Neoplasms; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myc; RNA, Small Interfering; Sp1 Transcription Factor; Vascular Endothelial Growth Factor A | 2009 |
Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Amino Acid Sequence; Animals; Apoptosis; ATPases Associated with Diverse Cellular Activities; Calcium Signaling; Cell Line, Tumor; Cytoprotection; Doxorubicin; Female; GTP-Binding Proteins; Humans; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Lipoylation; Lysophospholipids; Mice; Molecular Sequence Data; Mutation; Ovarian Neoplasms; Phosphoproteins; Proteasome Endopeptidase Complex; Protein Binding; Receptors, Lysophosphatidic Acid; Sodium-Hydrogen Exchangers; Transcription Factors | 2009 |
Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis.
Topics: Blotting, Western; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Claudin-1; Cluster Analysis; Female; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Membrane Proteins; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Polymerase Chain Reaction; Transcription, Genetic | 2009 |
Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice.
Topics: Animals; Arachidonate 15-Lipoxygenase; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooxygenase 1; Female; Group IV Phospholipases A2; Humans; Immunocompetence; Lysophospholipids; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Tumor Stem Cell Assay | 2009 |
Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Movement; Cell Survival; Curcumin; Dose-Response Relationship, Drug; Female; Humans; Interleukin-6; Interleukin-8; Janus Kinases; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Signal Transduction; STAT3 Transcription Factor; Transfection; Tyrphostins | 2010 |
VEGFR-2 silencing by small interference RNA (siRNA) suppresses LPA-induced epithelial ovarian cancer (EOC) invasion.
Topics: Cell Line, Tumor; Epithelial Cells; Female; Humans; Lysophospholipids; Neoplasm Invasiveness; Neuropilin-1; Neuropilin-2; Ovarian Neoplasms; RNA Interference; RNA, Small Interfering; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2009 |
Epidermal growth factor increases lysophosphatidic acid production in human ovarian cancer cells: roles for phospholipase D2 and receptor transactivation.
Topics: Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Female; Genetic Vectors; Humans; Lysophospholipids; Ovarian Neoplasms; Pertussis Toxin; Phospholipase D; Protein-Tyrosine Kinases; Receptor Cross-Talk; Receptors, Lysophosphatidic Acid; Transcriptional Activation; Transfection | 2010 |
Fasudil inhibits lysophosphatidic acid-induced invasiveness of human ovarian cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Carcinoma; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Female; Humans; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Ovarian Neoplasms; rho-Associated Kinases; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2009 |
Ovarian cancer-derived lysophosphatidic acid stimulates secretion of VEGF and stromal cell-derived factor-1 alpha from human mesenchymal stem cells.
Topics: Actins; Adipose Tissue; Cell Line, Tumor; Chemokine CXCL12; Culture Media, Conditioned; Endothelial Cells; Female; Humans; Lysophospholipids; Mesenchymal Stem Cells; Microphthalmia-Associated Transcription Factor; Neovascularization, Physiologic; Ovarian Neoplasms; Paracrine Communication; Receptors, Lysophosphatidic Acid; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Vascular Endothelial Growth Factors | 2010 |
Lysophosphatidic acid-induced expression of periostin in stromal cells: Prognoistic relevance of periostin expression in epithelial ovarian cancer.
Topics: Actins; Adult; Aged; Carcinoma, Ovarian Epithelial; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Female; Fibroblasts; Humans; Immunohistochemistry; Lysophospholipids; Middle Aged; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Prognosis; Stromal Cells | 2011 |
Role of the 18:1 lysophosphatidic acid-ovarian cancer immunoreactive antigen domain containing 1 (OCIAD1)-integrin axis in generating late-stage ovarian cancer.
Topics: Antibodies, Neoplasm; Biological Assay; Blotting, Western; Cell Adhesion; Cell Extracts; Cell Line, Tumor; Female; Humans; Integrins; Lysophospholipids; Models, Biological; Neoplasm Proteins; Neoplasm Staging; Ovarian Neoplasms; Phosphorylation; Protein Binding | 2010 |
The dire need to develop a clinically validated screening method for the detection of early-stage ovarian cancer.
Topics: beta-Defensins; Biomarkers; Claudins; Early Detection of Cancer; Epididymal Secretory Proteins; Female; Humans; Kallikreins; Lysophospholipids; Neoplasm Staging; Osteopontin; Ovarian Neoplasms | 2010 |
Cancer biomarkers: can we turn recent failures into success?
Topics: Animals; Antigens, Neoplasm; Biomarkers, Tumor; CA-125 Antigen; Clinical Trials as Topic; Female; Humans; Lysophospholipids; Male; Mass Screening; Mass Spectrometry; Neoplasms; Nuclear Magnetic Resonance, Biomolecular; Osteopontin; Ovarian Neoplasms; Predictive Value of Tests; Prognosis; Prostatic Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Validation Studies as Topic | 2010 |
Reactive oxygen species mediate lysophosphatidic acid induced signaling in ovarian cancer cells.
Topics: Antioxidants; Apoptosis; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; Genes, Reporter; Humans; Lysophospholipids; NADPH Oxidases; NF-kappa B; Onium Compounds; Organophosphates; Ovarian Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Reactive Oxygen Species; Receptors, Lysophosphatidic Acid; Signal Transduction; Up-Regulation | 2010 |
Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer.
Topics: Animals; Apolipoprotein A-I; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Drinking Behavior; Female; Humans; Injections; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Transplantation; Ovarian Neoplasms; Peptides; Precancerous Conditions; Survival Analysis; Tumor Burden; Water | 2010 |
Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cisplatin; Computational Biology; Docetaxel; Drug Resistance, Neoplasm; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Polymerase Chain Reaction; RGS Proteins; Signal Transduction; Taxoids; Vincristine | 2010 |
Lysophosphatidic acid (LPA)—a perspective marker in ovarian cancer.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Case-Control Studies; Female; Humans; Lysophospholipids; Middle Aged; Neoplasm Staging; Neoplasms, Cystic, Mucinous, and Serous; Ovarian Neoplasms; Retrospective Studies; Sensitivity and Specificity | 2011 |
MMP-1-PAR1 axis mediates LPA-induced epithelial ovarian cancer (EOC) invasion.
Topics: Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Female; Humans; Lysophospholipids; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; RNA, Messenger; RNA, Small Interfering; Transfection | 2011 |
Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Animals; Blotting, Western; Cell Line, Tumor; Cell Movement; Cytoskeletal Proteins; Female; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Mice, Nude; Middle Aged; Multiprotein Complexes; Neoplasm Metastasis; Neoplasm Staging; Neoplasms, Experimental; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; RNA Interference; SOS1 Protein; Transplantation, Heterologous; Young Adult | 2010 |
L-5F, an apolipoprotein A-I mimetic, inhibits tumor angiogenesis by suppressing VEGF/basic FGF signaling pathways.
Topics: Amino Acid Sequence; Angiogenesis Inhibitors; Animals; Apolipoprotein A-I; Blood Vessels; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblast Growth Factor 2; Gene Expression; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Mice, Inbred C57BL; Models, Biological; Molecular Mimicry; Molecular Sequence Data; Neovascularization, Pathologic; Neovascularization, Physiologic; Ovarian Neoplasms; Peptide Fragments; Peptides; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Fibroblast Growth Factor, Type 1; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
Activation of AMP-activated protein kinase is essential for lysophosphatidic acid-induced cell migration in ovarian cancer cells.
Topics: AMP-Activated Protein Kinases; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Line, Tumor; Cell Membrane; Cell Movement; Cytoskeleton; Enzyme Activation; Female; Humans; Lysophospholipids; Neoplasm Metastasis; Ovarian Neoplasms; Phospholipase C beta; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein | 2011 |
The NF-κB pathway mediates lysophosphatidic acid (LPA)-induced VEGF signaling and cell invasion in epithelial ovarian cancer (EOC).
Topics: Carcinoma, Ovarian Epithelial; Cell Line, Tumor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Matrix Metalloproteinases; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; NF-kappa B; Ovarian Neoplasms; Signal Transduction; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
Lysophosphatidic acid-induced p21Waf1 expression mediates the cytostatic response of breast and ovarian cancer cells to TGFβ.
Topics: Breast Neoplasms; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Drug Synergism; Female; Humans; Immunohistochemistry; Lysophospholipids; Ovarian Neoplasms; Phosphorylation; Transforming Growth Factor beta | 2011 |
MicroRNA-30c-2* expressed in ovarian cancer cells suppresses growth factor-induced cellular proliferation and downregulates the oncogene BCL9.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genome, Human; Humans; Lysophospholipids; MicroRNAs; Neoplasm Proteins; Ovarian Neoplasms; Platelet-Derived Growth Factor; Receptors, Lysophosphatidic Acid; Signal Transduction; Transcription Factors; Transfection | 2011 |
The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion.
Topics: Amides; Cell Line, Tumor; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Neoplasm Invasiveness; NF-kappa B; Nitriles; Ovarian Neoplasms; Peptide Hydrolases; Pyridines; rho-Associated Kinases; Sulfones; Urokinase-Type Plasminogen Activator | 2012 |
Apolipoprotein A-I mimetic peptides inhibit expression and activity of hypoxia-inducible factor-1α in human ovarian cancer cell lines and a mouse ovarian cancer model.
Topics: Animals; Apolipoprotein A-I; Cell Line, Tumor; Cobalt; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Ovarian Neoplasms; Oxygen; Peptides; Peptidomimetics; Phosphorylation; Proteasome Endopeptidase Complex; Proteolysis; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Ribosomal Protein S6 Kinases, 70-kDa; Transcription, Genetic | 2012 |
Lysophosphatidic acid modulates the association of PTP1B with N-cadherin/catenin complex in SKOV3 ovarian cancer cells.
Topics: Adherens Junctions; Cadherins; Catenins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Lysophospholipids; Multiprotein Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-fyn; RNA Interference; RNA, Small Interfering; Signal Transduction; src-Family Kinases | 2012 |
Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.
Topics: Animals; Cell Line, Tumor; Fatty Acid Synthases; Female; Gene Expression Regulation, Neoplastic; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Lipogenesis; Lysophospholipids; Mice; Neoplasm Proteins; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; Regulatory Elements, Transcriptional; Signal Transduction | 2012 |
Elevated and secreted phospholipase A₂ activities as new potential therapeutic targets in human epithelial ovarian cancer.
Topics: Animals; Arachidonic Acids; Ascites; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Female; Humans; Lysophospholipids; Mice; Neoplasm Transplantation; Neoplasms, Glandular and Epithelial; Organophosphonates; Ovarian Neoplasms; Phospholipases A2, Secretory; Phosphoric Diester Hydrolases; Transplantation, Heterologous | 2012 |
EGFR mediates LPA-induced proteolytic enzyme expression and ovarian cancer invasion: inhibition by resveratrol.
Topics: Cell Line, Tumor; ErbB Receptors; Female; Humans; Immunoblotting; Immunoprecipitation; Lysophospholipids; Ovarian Neoplasms; Phosphorylation; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stilbenes | 2013 |
The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion.
Topics: Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Laminin; Lysophospholipids; Models, Biological; Myosins; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proteoglycans; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; rhoC GTP-Binding Protein; Signal Transduction | 2013 |
Lysophosphatidic acid, LPA: a bad boy becomes good.
Topics: Biomarkers, Tumor; Endometrium; Female; Glucose-6-Phosphate Isomerase; Glycoproteins; Humans; Lysophospholipids; Multienzyme Complexes; Ovarian Neoplasms; Ovary; Phosphodiesterase I; Phosphoric Diester Hydrolases; Placentation; Pregnancy; Pyrophosphatases | 2003 |
Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.
Topics: Cell Division; Cell Line, Tumor; Cell Movement; Cell Survival; DNA-Binding Proteins; DNA, Complementary; Female; Green Fluorescent Proteins; Humans; Hydrolysis; Luminescent Proteins; Lysophospholipids; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Phosphatidate Phosphatase; Precipitin Tests; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Telomerase; Transfection | 2003 |
Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells.
Topics: Cell Line, Tumor; Female; Humans; Interleukin-6; Interleukin-8; Lysophospholipids; Ovarian Neoplasms; Promoter Regions, Genetic; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Transcriptional Activation | 2004 |
Evidence for tight coupling of Gi protein-mediated lysophosphatidic acid receptor to stimulated cytokine production in ovarian cancer cell.
Topics: Adenosine Diphosphate Ribose; Catalysis; Cell Line, Tumor; Cytokines; Female; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Ovarian Neoplasms; Pertussis Toxin; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid | 2004 |
Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway.
Topics: Cell Movement; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; G1 Phase; Humans; Lysophospholipids; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Ovarian Neoplasms; Protein-Tyrosine Kinases; ras Proteins; Stimulation, Chemical | 2004 |
Protein kinase A inhibits lysophosphatidic acid induction of serum response factor via alterations in the actin cytoskeleton.
Topics: 1-Methyl-3-isobutylxanthine; Actin Cytoskeleton; Actins; Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Proliferation; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal Proteins; Cytoskeleton; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Paxillin; Phosphoproteins; Serum Response Factor; Tumor Cells, Cultured | 2004 |
Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation.
Topics: Adult; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-Associated Death Protein; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspases; Cattle; Cell Line, Tumor; Clone Cells; Down-Regulation; Drug Resistance, Neoplasm; Female; Humans; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Male; Membrane Glycoproteins; Middle Aged; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Up-Regulation | 2004 |
Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy.
Topics: Animals; Bacterial Proteins; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Extracellular Fluid; Female; Gene Expression; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Ovarian Neoplasms; Receptors, Cell Surface; Transcriptional Activation; Transfection | 2004 |
Up-regulation of interleukin-6 in human ovarian cancer cell via a Gi/PI3K-Akt/NF-kappaB pathway by lysophosphatidic acid, an ovarian cancer-activating factor.
Topics: Blotting, Western; Cell Line, Tumor; Electrophoretic Mobility Shift Assay; Enzyme Activation; Female; Heterotrimeric GTP-Binding Proteins; Humans; Interleukin-6; Lysophospholipids; NF-kappa B; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Up-Regulation | 2005 |
Lysophosphatidic acid enhances epithelial ovarian carcinoma invasion through the increased expression of interleukin-8.
Topics: Cell Line, Tumor; Cell Movement; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-8; Lysophospholipids; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Ovarian Neoplasms | 2004 |
Upregulation of FasL by LPA on ovarian cancer cell surface leads to apoptosis of activated lymphocytes.
Topics: Apoptosis; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Cell Membrane; Coculture Techniques; Enzyme Activation; Fas Ligand Protein; Female; Humans; Lymphocyte Activation; Lysophospholipids; MAP Kinase Signaling System; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Ovarian Neoplasms; Phospholipases A; Phospholipases A2; Up-Regulation | 2004 |
Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells.
Topics: Adenoviridae; Animals; Binding Sites; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Genes, Dominant; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Mutation; Neoplasm Invasiveness; NF-kappa B; Ovarian Neoplasms; Promoter Regions, Genetic; raf Kinases; ras Proteins; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Signal Transduction; Transfection; Up-Regulation; Urokinase-Type Plasminogen Activator | 2005 |
Translocation of Fas by LPA prevents ovarian cancer cells from anti-Fas-induced apoptosis.
Topics: Apoptosis; Caspases; Cell Membrane; Cell Movement; Cytosol; Down-Regulation; Enzyme Activation; Fas Ligand Protein; fas Receptor; Female; Humans; Immunoglobulin M; Lysophospholipids; Membrane Glycoproteins; Neoplasm Invasiveness; Ovarian Neoplasms | 2005 |
Lysophosphatidic acid stimulates fas ligand microvesicle release from ovarian cancer cells.
Topics: Blotting, Western; Cytoskeleton; Enzyme-Linked Immunosorbent Assay; Fas Ligand Protein; Female; Flow Cytometry; Humans; Lysophospholipids; Membrane Glycoproteins; Microtubules; Neoplasm Metastasis; Ovarian Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2005 |
Lysophosphatidic acid inhibits anti-Fas-mediated apoptosis enhanced by actin depolymerization in epithelial ovarian cancer.
Topics: Actins; Antibodies; Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cytochalasin D; Cytoskeleton; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; fas Receptor; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Phosphorylation | 2005 |
Geranylgeranylacetone inhibits lysophosphatidic acid-induced invasion of human ovarian carcinoma cells in vitro.
Topics: Actins; Acute-Phase Proteins; Cell Shape; Cell Survival; Cytoskeletal Proteins; Diterpenes; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Humans; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Paxillin; Phosphoproteins; Phosphorylation; Tumor Cells, Cultured | 2005 |
Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells.
Topics: Cell Movement; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Induction; Enzyme Precursors; ErbB Receptors; Female; Gelatinases; Humans; Immunohistochemistry; Lysophospholipids; MAP Kinase Signaling System; Membrane Proteins; Metalloendopeptidases; Ovarian Neoplasms; Prostaglandin-Endoperoxide Synthases; Receptors, Lysosphingolipid; Transcriptional Activation | 2005 |
LPA-induced epithelial ovarian cancer (EOC) in vitro invasion and migration are mediated by VEGF receptor-2 (VEGF-R2).
Topics: Antibodies, Monoclonal; Cell Line, Tumor; Cell Movement; Cinnamates; Drug Interactions; Enzyme Activation; Female; Humans; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Ovarian Neoplasms; Urokinase-Type Plasminogen Activator; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2005 |
Lysophosphatidic acid, a disintegrin and metalloprotease-17 and heparin-binding epidermal growth factor-like growth factor in ovarian cancer: the first word, not the last.
Topics: ADAM Proteins; ADAM17 Protein; Antineoplastic Agents; Epidermal Growth Factor; Female; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Models, Biological; Ovarian Neoplasms; Signal Transduction | 2005 |
Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer.
Topics: Adjuvants, Immunologic; Apoptosis; Blotting, Northern; Blotting, Western; Caspase 3; Caspases; Cell Nucleus; Cell Proliferation; Chelating Agents; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Endothelins; Female; Guanine Nucleotide Exchange Factors; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovarian Neoplasms; Pertussis Toxin; Poly(ADP-ribose) Polymerases; Progranulins; Tumor Cells, Cultured | 2005 |
Surface-enhanced Raman scattering detection of lysophosphatidic acid.
Topics: Biomarkers, Tumor; Cell Surface Extensions; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Silver; Spectrum Analysis, Raman | 2005 |
KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha.
Topics: Animals; Cell Movement; Cell Proliferation; Down-Regulation; Female; Humans; Kisspeptins; Lysophospholipids; Mice; Mice, Nude; Neoplasm Metastasis; Ovarian Neoplasms; Protein Kinase C-alpha; Proteins; Transplantation, Heterologous; Tumor Suppressor Proteins | 2005 |
The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration.
Topics: Cell Membrane; Cell Movement; Cytoskeleton; Female; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Genes, ras; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mutation; Ovarian Neoplasms; Pertussis Toxin; Phosphorylation; Protein Serine-Threonine Kinases; ras Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tumor Cells, Cultured | 2006 |
[Expression of lysophosphatidic acid receptor in human ovarian cancer cell lines 3AO, SKOV3, OVCAR3 and its significance].
Topics: Cell Line, Tumor; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; RNA, Messenger | 2005 |
Selective induction of cyclooxygenase-2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentation.
Topics: Animals; Antigen Presentation; Antigens, Surface; Apoptosis; Aspirin; Cell Line, Tumor; Cell Membrane; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fas Ligand Protein; Female; Flavonoids; Humans; Lymphocyte Activation; Lymphocytes; Lysophospholipids; Membrane Glycoproteins; Nitrobenzenes; Ovarian Neoplasms; Quinazolines; Signal Transduction; Sulfonamides; Tumor Necrosis Factors; Tyrphostins | 2006 |
Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer.
Topics: Ascites; Cell Line, Tumor; Chemokine CXCL1; Chemokines, CXC; Down-Regulation; Female; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Intercellular Signaling Peptides and Proteins; Isoxazoles; Lysophospholipids; Ovarian Neoplasms; Pertussis Toxin; Propionates; Receptors, Lysophosphatidic Acid; Transcriptional Activation | 2006 |
Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells.
Topics: Arachidonic Acids; Cell Adhesion; Cell Line, Tumor; Cell Movement; Collagen Type I; Culture Media, Conditioned; Cytosol; Epithelium; Extracellular Signal-Regulated MAP Kinases; Female; Group VI Phospholipases A2; Humans; Isoenzymes; Lysophospholipids; Naphthalenes; Ovarian Neoplasms; Peritoneal Cavity; Peritoneum; Phosphodiesterase Inhibitors; Phospholipases A; Proto-Oncogene Proteins c-akt; Pyrones | 2006 |
Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers.
Topics: Biomarkers, Tumor; Carbohydrate Sequence; Europium; Female; Fluorescent Dyes; Gangliosides; Humans; Hydrogen-Ion Concentration; Lanthanum; Lysophospholipids; Methanol; Molecular Sequence Data; Neoplasms; Ovarian Neoplasms; Salicylates | 2006 |
Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells.
Topics: Apoptosis; Calcium; Caspase 3; Cell Movement; Enzyme Activation; Female; Humans; Integrins; Laminin; Lysophospholipids; Models, Biological; Ovarian Neoplasms; Phospholipases A; Phospholipases A2 | 2006 |
Hypoxia enhances lysophosphatidic acid responsiveness in ovarian cancer cells and lysophosphatidic acid induces ovarian tumor metastasis in vivo.
Topics: Cell Hypoxia; Cell Movement; Female; Humans; Lysophospholipids; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Tumor Cells, Cultured | 2006 |
[Lysophosphatidic acid in ovarian cancer patients].
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma; Female; Humans; Lysophospholipids; Middle Aged; Ovarian Neoplasms | 2006 |
Inhibition of matrilysin expression by antisense or RNA interference decreases lysophosphatidic acid-induced epithelial ovarian cancer invasion.
Topics: Carcinoma; Female; Humans; Lysophospholipids; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; RNA Interference; RNA, Small Interfering; Tumor Cells, Cultured | 2006 |
Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion.
Topics: Animals; Cell Movement; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2007 |
Lysophosphatidic acid down-regulates stress fibers and up-regulates pro-matrix metalloproteinase-2 activation in ovarian cancer cells.
Topics: Cell Line, Tumor; Down-Regulation; Enzyme Activation; Enzyme Precursors; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Matrix Metalloproteinase 2; Ovarian Neoplasms; Protein Serine-Threonine Kinases; rho-Associated Kinases; rhoA GTP-Binding Protein; Stress Fibers; Transfection; Up-Regulation | 2007 |
SPARC inhibits LPA-mediated mesothelial-ovarian cancer cell crosstalk.
Topics: Cell Communication; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemotaxis; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Interleukin-6; Lysophospholipids; Neoplasm Invasiveness; Osteonectin; Ovarian Neoplasms; Receptors, Lysophosphatidic Acid; RNA, Messenger; Signal Transduction | 2007 |
Geranylgeranylacetone inhibits ovarian cancer progression in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Disease Progression; Diterpenes; Dose-Response Relationship, Drug; Female; Humans; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; Ovarian Neoplasms; Phosphorylation; ras Proteins; Time Factors; Xenograft Model Antitumor Assays | 2007 |
[Lysophosphatidic acid promotes transplanted tumor growth of human epithelium ovarian cancer in nude mice].
Topics: Animals; Female; Lysophospholipids; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Ovarian Neoplasms; Peritoneal Neoplasms; Random Allocation; Transplantation, Heterologous; Tumor Burden | 2007 |
Inhibition of calcium-independent phospholipase A2 suppresses proliferation and tumorigenicity of ovarian carcinoma cells.
Topics: Animals; Apoptosis; Blotting, Western; Calcium; Cell Division; Cell Proliferation; Cyclins; Cytosol; Epidermal Growth Factor; Female; G2 Phase; Group VI Phospholipases A2; Humans; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Naphthalenes; Ovarian Neoplasms; Phospholipases A; Phospholipases A2; Pyrones; RNA, Small Interfering; S Phase; Tumor Cells, Cultured | 2007 |
VEGF- and LPA-induced telomerase in human ovarian cancer cells is Sp1-dependent.
Topics: Cell Growth Processes; Cell Line, Tumor; Enzyme Induction; Female; Humans; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovarian Neoplasms; Promoter Regions, Genetic; Sp1 Transcription Factor; Telomerase; Transcription, Genetic; Up-Regulation; Vascular Endothelial Growth Factor A | 2007 |
Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway.
Topics: Biological Transport; Cell Differentiation; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Lysophospholipids; MAP Kinase Signaling System; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Phospholipase D; Receptors, Lysophosphatidic Acid; Signal Transduction; Urokinase-Type Plasminogen Activator | 2007 |
S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells.
Topics: Actins; Biocompatible Materials; Blotting, Western; Cadherins; Carcinoma; Cell Adhesion; Cell Line, Tumor; Collagen; Drug Combinations; Extracellular Matrix; Female; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Humans; Laminin; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Proteoglycans; Sphingosine | 2007 |
Protein kinase C alpha-CARMA3 signaling axis links Ras to NF-kappa B for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells.
Topics: Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Cell Line, Tumor; Female; Humans; Lysophospholipids; Neoplasm Invasiveness; NF-kappa B; Ovarian Neoplasms; Protein Kinase C-alpha; ras Proteins; Signal Transduction; Up-Regulation; Urokinase-Type Plasminogen Activator | 2008 |
Determination of serum lysophosphatidic acid as a potential biomarker for ovarian cancer.
Topics: Biomarkers, Tumor; Chromatography, Gas; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Reproducibility of Results | 2007 |
Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: their inhibition by resveratrol.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Mitogen-Activated Protein Kinases; Ovarian Neoplasms; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Stilbenes; Transfection; Vascular Endothelial Growth Factor A | 2007 |
Use of lysophosphatidic acid in the management of benign and malignant ovarian tumors.
Topics: Adult; Age Factors; Biomarkers, Tumor; CA-125 Antigen; Female; Humans; Lysophospholipids; Middle Aged; Ovarian Neoplasms; Ultrasonography | 2007 |
Lysophosphatidic acid in malignant ascites stimulates migration of human mesenchymal stem cells.
Topics: Ascites; Calcium; Cell Movement; Cells, Cultured; Female; Humans; Lysophospholipids; Mesenchymal Stem Cells; Ovarian Neoplasms; Peritoneal Neoplasms; rhoA GTP-Binding Protein | 2008 |
Cancer-derived lysophosphatidic acid stimulates differentiation of human mesenchymal stem cells to myofibroblast-like cells.
Topics: Actins; Adipocytes; Adult; Aged; Animals; Ascites; Autocrine Communication; Cell Differentiation; Chemokine CXCL12; Female; Fibroblasts; Humans; Lysophospholipids; Mesenchymal Stem Cells; Middle Aged; Ovarian Neoplasms; Rats; Receptors, Lysophosphatidic Acid; Smad2 Protein; Smad3 Protein; Stem Cells; Transforming Growth Factor beta1 | 2008 |
Lysophosphatidic acid (LPA) promotes E-cadherin ectodomain shedding and OVCA429 cell invasion in an uPA-dependent manner.
Topics: Cadherins; Cell Line, Tumor; Down-Regulation; Female; Humans; Immunoglobulin Fc Fragments; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Protein Structure, Tertiary; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urokinase-Type Plasminogen Activator | 2008 |
Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells.
Topics: Adenylyl Cyclases; Cell Line, Tumor; Cell Movement; Colforsin; Cyclic AMP; Female; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Mutagenesis; Mutant Proteins; Ovarian Neoplasms; Pertussis Toxin; Protein Isoforms; RGS Proteins; Signal Transduction; Wound Healing | 2008 |
Quantitative determination of lysophosphatidic acid by LC/ESI/MS/MS employing a reversed phase HPLC column.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Thin Layer; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Quality Control; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
[Vector construction and silencing effect of Edg4 gene targeted small interfering RNA in ovarian cancer cell line].
Topics: Apoptosis; Cell Line, Tumor; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Vectors; Humans; Lysophospholipids; Ovarian Neoplasms; Plasmids; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Transfection | 2007 |
Ovarian cancer immuno-reactive antigen domain containing 1 (OCIAD1), a key player in ovarian cancer cell adhesion.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Cell Adhesion; Cell Line, Tumor; Collagen Type I; Down-Regulation; Female; Humans; Laminin; Lysophospholipids; Neoplasm Proteins; Ovarian Neoplasms; Paclitaxel; Protein Isoforms; Up-Regulation | 2008 |
Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells.
Topics: Antibodies; Cell Line, Tumor; Cell Movement; Cyclic AMP; DNA Primers; Female; Gene Deletion; Humans; Lysophospholipids; Multienzyme Complexes; Ovarian Neoplasms; Phosphodiesterase I; Phosphoric Diester Hydrolases; Polymerase Chain Reaction; Pyrophosphatases; RNA, Messenger; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2008 |
Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells.
Topics: Antigens, Surface; Arachidonic Acid; Base Sequence; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cyclooxygenase 2; Dinoprostone; DNA Primers; ELAV Proteins; ELAV-Like Protein 1; Female; Humans; Lysophospholipids; Mutagenesis, Site-Directed; Ovarian Neoplasms; Phosphorylation; Receptor Protein-Tyrosine Kinases; Receptors, Lysophosphatidic Acid; RNA Processing, Post-Transcriptional; RNA Stability; RNA-Binding Proteins; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering; Sequence Deletion; Signal Transduction; Transcriptional Activation | 2008 |
Inhibition of lysophosphatidic acid receptor-2 expression by RNA interference decreases lysophosphatidic acid-induced urokinase plasminogen activator activation, cell invasion, and migration in ovarian cancer SKOV-3 cells.
Topics: Cell Growth Processes; Cell Line, Tumor; Cell Movement; Chemotaxis; Enzyme-Linked Immunosorbent Assay; Female; Humans; In Vitro Techniques; K562 Cells; Lysophospholipids; Ovarian Neoplasms; Pilot Projects; Receptors, Lysophosphatidic Acid; RNA Interference; RNA, Messenger; Signal Transduction; Urokinase-Type Plasminogen Activator | 2008 |